Dennis H. Auckley, M.D.
Assistant Professor of Medicine, CWRU
Director, Center for Sleep Medicine
Co-Program Director, Pulmonary and Critical Care Fellowship Program
Co-Program Director, CWRU Sleep Fellowship Program
TEL: (216) 778-2286
FAX: (216) 778-3240

Curriculum Vitae

Research Interest(s)
Sleep disordered breathing and perioperative risk
Sleep disordered breathing and asthma
Treatment of sleep disordered breathing

Selected Publications
Baron J and Auckley D. “Gunshot wound to the head: an unusual complication of sleep apnea and bilevel pressure support.” Accepted for publication in Sleep and Breathing, 2004

Auckley D and Hudgel D. “Management of obstructive sleep apnea syndrome.” Respiratory Care: Principles and Practice. Saunders Co., copyright 2002, Chapter 58: 1139-1150

Auckley D, Crowell R, Heaphy E, Stidley C, Lechner J, Gilliland F, and Belinsky S. “Reduced DNA-dependent protein kinase active is associated with lung cancer.” Carcinogenesis 22 (5):723-727, 2001

Auckley D, Schmidt-Nowara W, and Brown L. “Reversal of sleep apnea hypopnea syndrome in end stage renal disease following kidney transplantation.” American Journal of Kidney Disease 34(4): 739-744, 1999

Mark P. Aulisio, Ph.D.
Director, Clinical Ethics Program
MetroHealth Medical Center
Center for Biomedical Ethics
Case Western Reserve University
TEL: (216) 778-7290
FAX: (216) 778-3360

Biographical Information at Case

Research Interest(s)
Biomedical Ethics, Moral and Political Philosophy, Action Theory

Selected Publications
Mark P. Aulisio, Robert M. Arnold, and Stuart J. Youngner, Ed. Bioethics Consultation: Theoretical and Practical Issues (Baltimore, Maryland: The Johns Hopkins University Press, under contract, expected publication 2001).

The Society for Health and Human Values - Society for Bioethics Consultation Task Force on Standards for Bioethics Consultation, Core Competencies for Health Care Ethics Consultation: The Report of the American Society for Bioethics and Humanities (Lake View, Illinois: American Society for Bioethics and Humanities, 1998), 45 pp.

Mark P. Aulisio, "Standards for Decision Making at the End of Life" in T. May and P. Tudico, eds. Advance Directives and Surrogate Decision Making in Illinois, (Springfield, Illinois: Southern Illinois University School of Medicine Medical Humanities Series, 1999).

vMark P. Aulisio, Robert M. Arnold, and Stuart J. Youngner, "Can There be Educational and Training Standards for Those Conducting Health Care Ethics Consultation?" in D. Thomasma and J. Monagle, ed. Health Care Ethics: Critical Issues for the 21st Century, (Gathersburg, Maryland: Aspen Publishers, 1998), 484-496.

Robert C. Bahler, M.D.
Professor of Medicine
Staff Cardiologist
MetroHealth Medical Center
Case Western Reserve University
TEL: (216) 778-3875
FAX: (216) 778-3927


Research Interest(s)
Noninvasive evaluation of cardiac function.

Selected Publications
Finkelhor RS, Pajouh A, Kett A, Stefanski R, Bosich G, Youssefi M, Bahler RC. Clinical impact of second harmonic imaging and left heart contrast in echocardiographic stress testing. Am J Cardiol 2000;85:740-743.

Bahler RC, Desser D, Finkelhor RS, Brener SJ, Youseffi M. Factors leading to progression of valvular aortic stenosis. Am J Cardiology 1999;84:1044-1048.

Golzari H, Cebul R, Bahler RC. Review Atrial Fibrillation: Restoration and maintenance of sinus rhythm and indications for anticoagulation. Annals of Internal Medicine; 1996;125:311-323.

Sandhu R, Bahler RC. Prevalence of QRS prolongation in a community hospital cohort of patients with heart failure and its relation to left ventricualr systolic dysfunction. Am J Cardiol 2004;93:244-246.

Jennifer L. Bailit, M.D., M.P.H.
Assistant Professor of Reproductive Biology
Department of Obstetrics & Gynecology
Director of Labor and Delivery
Division of Maternal-Fetal Medicine
MetroHealth Medical Center
Center for Health Care Research & Policy Senior Scholar
Women’s Reproductive Health Research Program Scholar
TEL: (216) 778-7341
FAX: (216) 778-8847

Biosketch
Curriculum Vitae

Research Interest(s)
Dr. Bailit’s research focuses on how to assess and improve the quality of obstetrical care. She is interested in using risk-adjusted primary cesarean rates as a marker of quality and in examining factors that are associated with higher quality obstetrical care. Dr. Bailit works with large data sets such as birth certificate data. The overall goal of her research is to improve the quality of obstetrical care.

Selected Publications
Bailit JL, for the NICHD MFMU Network. The MFMU Cesarean Registry: Impact of time of day on Cesarean Complications. American Journal of Obstetrics and Gynecology 2006; 195(4):1132-1137.

Bailit JL, Love TE, Dawson NV, Quality of obstetric care and risk-adjusted primary cesarean rates. American Journal of Obstetrics and Gynecology. 2006, 194:2;401-407.

Boggess K, Bailit JL, Singer M, Parisi, VM, Mercer BM, Projected benefits of universal or scheduled antepartum corticosteroids to prevent neonatal morbidity: A decision analysis. American Journal of Obstetrics and Gynecology. 2005, 193: 4;1415-1423.

Bailit JL, Dierker L, Blanchard M Hsieh, Mercer BM, Outcomes of women presenting in active versus latent phase of spontaneous labor. Obstetrics and Gynecology. 2005, 105; 1:77-79.

Bailit JL, Love T, Mercer, BM Rising Cesarean rates: Are patients sicker? American Journal of Obstetrics and Gynecology. 2004, 191; 3:800-803.

Stanley Ballou, M.D.
Director of Rheumatology
MetroHealth Medical Center
Associate Professor
Case Western Reserve University
TEL: (216) 778-5154, (216) 778-4765
FAX: (216) 778-8376


Research Interest(s)
Lupus Erythematosus

Rachele Berria, M.D., M.S.C.I.
Assistant Professor of Reproductive Biology
Case Western Reserve University
MetroHealth Medical Center
TEL: (216) 778-4466
FAX: (216) 778-2109

Curriculum Vitae

Research Interest(s)
The Role of White Adipose Tissue Adiponutrin During Healthy and Gestational Diabetic Pregnancy

Pregnancy is characterized by a steady decrease of insulin sensitivity. GDM occurs when the pancreatic b cell compensatory function becomes insufficient to counteract the pregnancy-induced insulin resistance. Moreover, pregnancy is characterized by lipogenesis and fat storage in variable entities in early and mid gestation, whereas enhanced lipolysis and fat oxidation (1) take place during late pregnancy. Concomitant changes in the mRNA expression of lipoprotein lipase and hormone-sensitive lipase have been observed (2) during early and late pregnancy, respectively, in WAT. WAT has gained interest in recent years, as it is now known to be a dynamic organ, able to communicate with other key tissues in the body and to secrete a variety of proteins. Adiponutrin was recently identified (3) as a non-secreted adipocyte protein which is regulated by changes in energy balance and associated with lipogenesis. However, its mRNA and protein expression, and relationship with genes involved in energy metabolism has yet to be elucidated during the course of healthy and gestational diabetic pregnancy.

The overall purpose of the ongoing studies is to investigate the role of adiponutrin in white adipose tissue (WAT) during the course of pregnancy. Adiponutrin mRNA expression and protein concentration in WAT are determined, its cross-talk with well-known molecules linked to lipogenesis and lipolysis in WAT is being investigated, together with its repercussion on whole body oxidative fuel utilization, during the early and late stages of healthy and pregnancies with Gestational Diabetes Mellitus (GDM).

Therefore, the specific aims of the ongoing studies are:
1. To evaluate the longitudinal changes in white adipose subcutaneous abdominal cell size and distribution throughout pregnancy.
2. To evaluate longitudinal changes in the expression of adiponutrin during pregnancy.
3. To evaluate mRNA levels of lipogenesis-related molecules (i.e. aP2, CD36, glycerol kinase, SREBP-1, SCD-1, FATP-1) and lipolysis related molecules (ATGL, HSL, ACS, phosphodiesterase 3B) in WAT at different stages in normal and GDM patients.
4. To investigate the presence of cross-talk between adiponutrin and molecules involved in energy metabolism.

Martin-Hidalgo A, Holm C, Belfrage P et al. Lipoprotein lipase and hormone sensitive lipase activity and mRNA in rat adipose tissue during pregnancy. Am J Physiol Endocrinol Metab 266: E930-35, 1994.

Jenkins CM, Mancuso D, Yan W et al. Identification, cloning, expression and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 279: 48968-75, 2004.

Okereke NC, Huston-Presley L, Amini SB et al. Longitudinal changes in energy expenditure and body composition in obese women with normal and impaired glucose tolerance. Am J Physiol Endocrinol Metab 287: E472-9, 2004.

Selected Publications
Berria R, Gastaldelli A, Lucidi S, Belfort R, DeFilippis E, Easton C, Brytzki R, Cusi K, Jovanovic L and DeFronzo RA. Reduction in Hematocrit Following Pioglitazone Treatment is Related to Decrease in Plasma Free Testosterone, not to Hemodilution in Women with PCOS. Clin Pharmacol and Therapeutics 80(2);105-14, 2006.

Murgia C, Berria R, Minerba L, Malloci B, Daniele C, Zedda P, Ciccotto MG, Sulis S, Murenu M, Tiddia F, Manai M and Melis GB. Gestational Diabetes Mellitus in Sardinia: Results from an early, universal screening procedure. Diab Care 29(7):1713-4, 2006.

Sriwijiktamol A, Christ-Roberts CY, Berria R, Eagan P, Pratipanawatr T, DeFronzo RA, Mandarino LJ and Musi N. Reduced skeletal muscle inhibitor of KappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training. Diabetes 55(3):760-7, 2006.

Berria R, Wang L, Richardson D, Finlayson J, DeFilippis E and Mandarino LJ. Increased Collagen Content in Insulin Resistant Skeletal Muscle Am J Physiol Endocrinol Metab 290:560-5, 2006.

Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo RA, Finlayson J, Kahn R and Mandarino LJ. Coordinated Reduction of Oxidative Metabolism Genes in Mexican-American Subjects with Insulin Resistance and Diabetes: Potential Role of PGC-1 and NRF-1. Proc Natl Acad Sci USA 100:8466-71, 2003.

David J. Birnkrant, M.D.
Associate Professor of Pediatrics, Case Western Reserve University
Head, Pediatric Pulmonology
Director, Student Education
Department of Pediatrics
MetroHealth Medical Center
TEL: (216) 778-4832
FAX: (216) 778-4223


Research Interest(s)
Respiratory complications of pediatric neuromuscular diseases; pediatric noninvasive mechanical ventilation; noninvasive mucus clearance techniques; perinatal asthma risk factors.

Selected Publications
Birnkrant DJ. The assessement and management of the respiratory complications of pediatric neuromuscular diseases. Clin Pediatr 2002; 41: 301-308.

Pope JF, Birnkrant DJ. Noninvasive ventilation to facilitate extubation in a pediatric intensive care unit. J Intensive Care Med 2002; 15: 99-103.

Birnkrant DJ, Pope JF, Eiben RM. Management of the respiratory complications of neuromuscular diseases in the pediatric intensive care unit. J Child Neurol 1999; 14: 139-143.

Birnkrant DJ, Pope JF, Martin JE, Repucci AH, Eiben RM. Treatment of type I spinal muscular atrophy with noninvasive ventilation and gastrostomy feeding. Pediatr Neurol 1998; 18: 407-410.

Pope JF, Birnkrant DJ, Martin JE, Repucci AH. Noninvasive ventilation during percutaneous gastrostomy placement in Duchenne muscular dystrophy. Pediatr Pulmonol 1997; 23: 468-471.

Carol E. Blixen, PhD, RN
Senior Scholar, Center for Health Care Research & Policy
Case Western Reserve University at MetroHealth Medical Center
Adjunct Associate Professor of Medicine
Department of Medicine
Case Western Reserve University
TEL: (216) 283-4134

Biosketch
Curriculum Vitae

Research Interest(s)
Dr. Blixen employs both qualitative and quantitative approaches (mixed methods) to examine the personal, behavioral, and sociocultural issues that impact on patients` medical decision making and adherence to treatment. She is currently looking at predictors of alcohol use among nonharmful drinkers with Hepatitis C.

Selected Publications
Blixen, C., Papp, K., Hull, A. , Rudick, R . & Bramstedt, K. (2007). Developing a mentorship program for clinical researchers. Journal of Continuing Education in the Health Professions. 27(2):22-29.

Stoller, E., Hund, A., Webster, N., Blixen, C., Perzynski, A., McCormick, R., Kanuch, S & Dawson, N. (2006) Alcohol consumption within the context of heapatitis C: A qualitative study of nondependent drinkers. Alcohol and Alcoholism.

Blixen, C., Singh, A., Thacker, H. (2006) Values and beliefs about obesity and weight reduction among African-American and Caucasian Women. Journal of Transcultural Nursing. (3):290-297.

Blixen, C., Singh, A., Xu, M., Thacker, H., & Mascha, E. (2006). What women want: understanding obesity and preferences for primary care weight reduction interventions among African American and Caucasian women. Journal of The National Medical Association. 98 (7):1160-1169

Blixen, C., Bramstedt, K., Hammel, J. & Tilley, B. (2004) Health education via a nurse-run telephone self-management program for older adults with osteoarthritis: A pilot study. Journal of Telemedicine and Telecare. 10 (1), 44-49.

Shari D. Bolen, M.D., M.P.H.
Practice-based Research Network (PBRN) Fellow
Case Western Reserve University
Physician, Division of Internal Medicine
MetroHealth Medical Center
TEL: (216) 778-5359
FAX: (216) 778-3945

Curriculum Vitae

Research Interest(s)
Dr. Bolen conducts health services research in diabetes and obesity, with an emphasis on ways to improve care. She has a special interest in comparative effectiveness research and systematic reviews/meta-analyses.

Selected Publications
Bolen SD, Bricker E, Samuels TA, Yeh HC, Marinopoulos SS, McGuire M et al. Factors associated with intensification of oral diabetes medications in primary care provider-patient dyads: a cohort study. Diabetes Care 2009; 32(1):25-31.

Bolen S, Feldman L, Vassy J, Wilson L, Yeh HC, Marinopoulos S, Wiley C, Selvin E, Wilson R, Bass EB, Brancati FL. Systematic Review: Comparative Effectiveness and Safety of Oral Medications for Type 2 Diabetes. Ann of Int Med 2007 Sep 18; 147(6): 386-399.

Bolen S, Tilburt J, Baffi C, Gary TL, Powe N, Howerton M, Ford JG, Lai G, Wilson R, Bass EB. Defining “Success” in Recruitment of Underrepresented Populations to Cancer Clinical Trials: Moving Toward a More Consistent Approach. Cancer 2006 Mar; 106(6): 1197-1204.

Maruthur NM, Bolen S, Brancati FL, Clark JM. Obesity and Mammography: A Systematic Review and Meta-Analysis. J Gen Intern Med 2009.

Nicholson W, Bolen S, Witkop CT, Neale D, Wilson L, Bass E. Benefits and risks of oral diabetes agents compared with insulin in women with gestational diabetes: a systematic review. Obstet Gynecol 2009; 113(1):193-205.

Andrea Bonny, M.D.
Staff Physician, Pediatrics
MetroHealth Medical Center
Assistant Professor
Case Western Reserve University
TEL: (216) 778-3065

Arthur Brown, M.D., Ph.D.
Sr. Staff Scientist
Professor, Physiology and Biophysics
TEL: (216) 778-5960
FAX: (216) 749-3889

Curriculum Vitae

Research Interest(s)
Ion channels are pores in cell membranes that transport ions at high rates. Ion channels are widespread and comprise about 15% of all known drug targets. We study their structure-function relationships, processing, regulation, genetics, and relation to disease (channelopathies). Modifier genes for hereditary and acquired (drug-induced) long QT syndrome are presently being pursued. The lab has also developed a reversible model of heart failure to study arrhythmias in this disease.

Selected Publications
Ficker E, Taglialatela M, Wible BA, Henley CM, Brown AM. Spermine and spermidine as gating molecules for inward rectifier K+ channels. Science. 1994 Nov 11;266(5187):1068-1072.

Wible BA, Yang Q, Kuryshev YA, Accili EA, Brown AM. Cloning and expression of a noval K+ channel regulatory protein, KChAP. J Biol Chem. 1998 May 8;273(19):11745-11751.

Kuryshev YA, Wible BA, Gudz Ti, Ramirez AN, Brown AM. KChAP/Kvb1.2 interactions and their effects on cardiac Kv channel expression. Am J Physiol Cell Physiol. 2001 Jul;281(1):C290-C299.

Leslie Bruggeman, Ph.D.
Associate Professor
Department of Medicine, MetroHealth Medical Center
Center for AIDS Research
Case Western Reserve University
TEL: (216) 778-7603
FAX: (216) 778-4321


Curriculum Vitae

Research Interest(s)
Molecular and cellular biology of chronic kidney diseases. Areas of special interest include: pathogenesis of HIV-associated nephropathy; transcriptional regulation of HIV-1 and eukaryotic gene expression; podocyte cell biology; transcriptional regulation during epithelial cell differentiation and in kidney development. In vitro modeling of the glomerular filtration barrier.

Selected Publications
Bruggeman, L. A., S. Martinka, and J. S. Simske. Expression of TM4SF10, a claudin/EMP/PMP22 family cell junction protein, during mouse kidney development and podocyte differentiation. Dev. Dyn. 236:596-605 (2007).

Ross, M. D., S. Martinka, A. Mukherjee, J. R. Sedor, C. Vinson, and L. A. Bruggeman. Math6 expression in kidney development and altered expression in a mouse model of glomerulosclerosis. Dev. Dyn. 235:3102-3109 (2006).

Martinka, S. and L. A. Bruggeman. Persistent NF-kB activation in renal epithelial cells in a transgenic mouse model of HIV-associated nephropathy. Am. J. Physiol. Renal Physiol. 290: F657-665 (2006).

Ross, M. J., S. Martinka, V. D. D’Agati, and L. A. Bruggeman. NF-kB regulates Fas-mediated apoptosis in HIV-associated nephropathy. J. Am. Soc. Nephrol. 16: 2403-2411 (2005).

Gharavi A. G., T. Ahmad, R. Wong, R. Hooshyar, J. Vaughn, S. Oller, R. Z. Frankel, L. A. Bruggeman, V. D. D`Agati, P. E. Klotman, and R. P. Lifton. Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3. Proc. Natl. Acad. Sci. 101:2488-2493 (2004).

Kevin D. Bunting, Ph.D.
Associate Professor of Medicine
Department of Medicine, Division of Hematology/Oncology
Case Western Reserve University
TEL: (216) 368-5694
FAX: (216) 368-1166


Research Interest(s)
My main area of research continued in the field of hematopoietic stem cell biology. Since these cells are potential targets for treating a wide variety of blood diseases, understanding the basic mechanisms regulating their proliferation, differentiation, self-renewal, mobilization, and migration is extremely important. These processes determine the efficacy of a stem cell transplant and they are directly relevant for possible clinical application in cell and gene therapy. We take a genetics approach to the study of signal transduction pathways and modulation of extracellular matrix interactions of stem cells. These studies heavily use transgenic and knockout mouse models for various genes of interest. This work is also directly relevant for the Case Cancer Center and the Center for Stem Cell and Regenerative Medicine, both of which I am actively involved.

There are two major areas of research that are funded by NIH R01 grants.
1. R01DK059380 - JAK/STAT Signaling in Hematopoietic Stem Cells – the purpose of this work is to define the role of two specific signal transducer and activator of transcription (STAT) family members in hematopoiesis. We are focused on STAT3 and STAT5 because these two factors are regulated by early acting hematopoietic cytokines. The STAT5 project is most well developed (Bunting et al., Blood, 2002; Bradley et al. Blood 2002; Bradley et al. Blood 2004). We have demonstrated a severe competitive repopulating defect in mice in which full-length STAT5a and STAT5b have been deleted. Current studies have focused on a remaining endogenous N-terminal truncated STAT5 alternative reading frame that is expressed at very low levels in these mice. In certain cell types, such as mast cells, we find that the truncated form is selected for and can confer unique cytokine responsiveness to stem cell factor (SCF). Ongoing studies will address the role of STAT5 in SCF responses and possible implications in adhesion, migration, or homing of stem cells. We have also obtained and are currently characterizing true null mice in collaboration with Lothar Hennighausen at the NIH.

2. R01HL073738 - Role of TIMPs in Hematopoietic Stem Cell Biology – the purpose of this work is to define the role of the tissue inhibitor of matrix metalloproteinase (TIMP)/matrix metalloproteinase (MMP) balance in controlling hematopoietic stem cell engraftment. We have developed retroviral vector systems for overexpression of TIMP-1, TIMP-2, and MMP-9 in wild-type and TIMP-1-/- mice. These studies will determine whether TIMPs have MMP-independent growth factor activity in regulating early hematopoiesis. Also, these studies will determine the effects of transgenic MMP-9 on the early engraftment and mobilization of hematopoietic stem and progenitor cells. MMP-9 release following cytokine or chemokine induced mobilization is believed to play a role in release of stem cells from the bone marrow niche, however, MMP-9 transgenic mice have never been reported. Further studies will address the physiological role of TIMP-1 as a negative regulator of MMP-9 under conditions of hematopoietic stress.

Selected Publications
Bradley, H.L., Hawley, T.S., Bunting, K.D. Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hemapoietic stem cells. Blood, (100); 3983-89, 2002.

Bradley, H.L., Couldrey, C., Bunting, K.D. Hematopoietic-repopulating defects from STAT5-deficient bone marrow are not fully accounted for by loss of thrombopoietin responsiveness. Blood, 103; 2965-72, 2004.

Haviernik, P. Lahoda, C., Bradley, H.L., Hawley, T.S., Ramezani, A., Hawley, R.G., Stetler-Stevenson, M., Stetler-Stevenson, W.G., Bunting, K.D. Tissue inhibitor of matrix metalloproteinase-1 overexpression in M1 myeloblasts impairs IL-6-induced differentiation. Oncogene (23); 9212-19, 2004.

James W. Campbell, M.D.
Chairperson, Director, Geriatric Health
Physician, Family Practice
MetroHealth Medical Center
Professor
Case Western Reserve University
TEL: (216) 778-8084

Patrick M. Catalano, M.D.
Chairman, Department of Obstetrics & Gynecology
MetroHealth Medical Center
Professor, Department of Reproductive Biology
Case Western Reserve University
Schwartz Center for Metabolism and Nutrition
MetroHealth Medical Center
TEL: (216) 778-7341, (216) 778-4876
FAX: (216) 778-1574


Curriculum Vitae

Research Interest(s)
The long range goals of our studies are to evaluate mechanisms related to insulin resistance in pregnancy and short and long term effects on the fetus. Currently our grant support is focused on evaluating mechanisms related to insulin resistance in maternal skeletal muscle and adipose tissues. Biopsies are taken prior to conception and again in early and late gestation, and evaluated for alterations in the insulin signaling cascade as they relate to the physiological changes in glucose and lipid insulin sensitivity. Recently, we have begun evaluation of gene expression in placental tissue as a potential signal for alteration of maternal nutrients resulting in excessive fetal growth and macrosomia. Additionally, we have ongoing long-term studies evaluating infants of women with normal glucose tolerance and gestational diabetes. We are evaluating these children’s insulin sensitivity and body composition. The underlying hypothesis is that the altered metabolic milieu of a diabetic pregnancy not only increases the risk of adiposity at birth, but also is a long-term risk for adolescent obesity and glucose intolerance. Lastly, in the clinical trial arena, we are a participant in the Multicenter National Study of Hyperglycemia and Adverse Perinatal Outcome (HAPO) in order to determine which values on an oral glucose tolerance are associated with maternal and fetal perinatal morbidity. All of the above studies are currently funded through the National Institutes of Health.

Selected Publications
CATALANO PM, Kirwan JP, Hauguel-de Mouzon S, King J. Gestational Diabetes and Insulin Resistance: Its role in the Short and Long Term Implications for Mother and Fetus. Am J Clin Nutr 133:1674S-1683S, 2003.

CATALANO PM, Thomas A, Huston-Presley L, Amini SB. Increased fetal adiposity: A very sensitive marker of abnormal in-utero development. Am J Obstet & Gynecol, 189:1698-704, 2003.

Durnwald C, Huston-Presley L, Amini S, CATALANO PM. Evaluation of body composition of large for gestational age infants of women with gestational diabetes compared with women with normal glucose tolerance. Am J Obstet Gynecol, 2004 (In Press)

Okereke N, Huston-Presley L, Amini SB, Kalhan S, CATALANO PM. Longitudinal changes in energy expenditure and body composition in obese women with normal and impaired glucose tolerance. Am J Physiol: Endocrin & Metab, 2004 (In Press)

Ehrenberg HM, Mercer, BM, CATALANO PM. The influence of obesity and diabetes on neonatal macrosomia. AJOG, 2004 (In press)

Grace Cater, M.D.
Staff Physician, Cardiology
Assistant Professor
Case Western Reserve University
TEL: (216) 778-2431


Research Interest(s)
General cardiology,
Non-Invasive Cardiology,
Cardiac Imaging

Randall D. Cebul, M.D.
Professor of Medicine, Epidemiology and Biostatistics
Director, Center for Health Care Research & Policy
TEL: (216) 778-3902
FAX: (216) 778-3945

Biosketch
Curriculum Vitae

Research Interest(s)
Dr. Cebul studies and applies methods in epidemiology and the decision sciences to examine and improve health care delivery. Areas of special emphasis include clinical policy-relevant research and decision support for preventive services and chronic illnesses. Current studies focus on diabetes and cerebrovascular disease.

Selected Publications
Votruba ME, Cebul RD. Redirecting patients to improve stroke outcomes: implications of a volume-based approach in one urban market. Med Care. 2006; 44 (12): 1129-1136

Murray PK, Dawson NV, Thomas CL, Cebul RD. Are we selecting the right patients for stroke rehabilitation in nursing homes? Arch Phys Med Rehabil. 2005;86(5):876-880.

Murray PK, Love TE, Dawson NV, Thomas CL, Cebul RD. Rehabilitation services following the implementation of the nursing home prospective payment system: differences related to patient and nursing home characteristics. Medical Care 2005 Nov;43(11):1109-15.

Katzan IL, Cebul RD, Baker DW, et.al. The effect of pneumonia on mortality among patients hospitalized for acute stroke. Neurology. 2003; 60:620-625.

Baker DW, Einstadter D, Thomas CL, Husak SS, Gordon NH, Cebul RD. Mortality trends during a program that publicly reported hospital performance. Med Care. 2002; 40: 879-890.

John Chae, M.D., M.E.
Associate Professor of PM&R
Director of Research
Case School of Medicine
Associate Professor of Biomedical Engineering
Case School of Engineering
Associate Director of Clinical Affairs
Cleveland Functional Electrical Stimulation Center
TEL: (216) 778-3472
FAX: (216) 778-1653


Curriculum Vitae

Research Interest(s)
Dr. Chae`s research focuses on the application of neuromuscular electrical stimulation to restore upper and lower extremity motor function in hemiplegia. The specific areas of focus include 1) treatment of shoulder subluxation and pain, 2) facilitation of motor recovery 3) development and implementation of neuroprostheses and relationship between neurophysiology, motor impairment and physical disability.

Selected Publications
Yu DT, Chae J, Walker ME et al. Intramuscular neuromuscular electrical stimulation for post-stroke shoulder pain: A multi-center randomized clinical trial. Arch Phys Med Rehabil 2004; 85: 695-704.

Chae J, Hart R. Intramuscular hand neuroprosthesis for chronic stroke survivors. Neurorehabil Neural Repair 2003; 17: 109-117.

Chae J, Yang G, Labatia I. Upper limb motor function in chronic hemiparesis: Concurrent validity of the Arm Motor Ability Test. Am J Phys Med Rehabil 2003; 82: 1-8.

Chae J, Yang G, Park BK, Labatia I. Muscle weakness and co-contraction in hemiparesis: Relationship to motor impairment and physical disability. Neurorehabil Neural Repair 2002: 16: 241-248.

Chae J, Yang G, Park BK, Labatia I. Delay in initiation and termination of muscle contraction, motor impairment and physical disability in upper limb hemiparesis. Muscle Nerve 2002; 25: 568-575.

Michael W. Cho, Ph.D.
Assistant Professor of Medicine
Department of Medicine,
Division of Infectious Diseases
Director, Molecular Virology and Gene Expression Core
Center for AIDS Research
Case Western Reserve University
TEL: (216) 844-7767
FAX: (216) 844-1409

Web Page

Research Interest(s)
Molecular virology and viral immunology of several important human pathogens, namely human immunodeficiency virus (HIV-1), smallpox, SARS coronavirus and West Nile virus. The primary activity of the lab is to develop and/or improve vaccines against HIV-1, smallpox and SARS-CoV. The laboratory uses molecular biology techniques to generate novel vaccine candidates and evaluate their immunogenicity in laboratory animals. The laboratory is also involved in characterizing structural-functional properties of viral proteins that allow viruses to enter cells as well as assessing host immune responses that are mounted against those proteins.

Selected Publications
Han, D. P., H. G. Kim, Y. B. Kim, L. L. M. Poon, M. W. Cho (2004). Development of a safe neutralization assay for SARS-CoV and Characterization of S glycoprotein. Virology. 326: 140-149.

Kim, Y. B., D. P. Han, C. Cao, M.W. Cho (2003). Immunogenicity and ability of variable loop-deleted human immunodeficiency virus type 1 envelope glycoproteins to elicit neutralizing antibodies. Virology 305: 124-137

Cho, M. W. (2003). Subunit protein vaccines: Theoretical and practical considerations for HIV-1. Curr. Mol. Med. 3:243-263. (Review).

James F. Clapp III, M.D.
Emeritus Professor of Reproductive Biology
Case Western Reserve University
TEL: (216) 778-4818
FAX: (216) 778-1574


Research Interest(s)
Currently Dr. Clapp is involved in studies examining the effects of supine exercise during pregnancy on uterine blood flow and fetal well-being, the effects of exercise during pregnancy on immune function, and the effects of exercise during pregnancy on long-term growth and development of the offspring. Other ongoing studies involve the effects of diet during pregnancy on maternal metabolism and fetal growth and the fetal effects of cord entanglement.

Selected Publications
CLAPP JF, Little KD, Widness JA. Effect of maternal exercise and feto-placental growth on serum erythropoietin. Am J Obstet Gynecol 188:1021-1025, 2003.

CLAPP JF, Schmidt S, Petry K, Lopez B.. The effects of maternal exercise on fetal oxygenation and feto-placental growth. EJOGRB 110: S80-S85, 2003.

CLAPP JF, Stepanchak W, Hashimoto K, EHRENBERG H, Lopez B. The natural history of antenatal nuchal cords. Am J Obstet Gynecol 189:488-493, 2003.

Clapp JF, Kett A, Olariu N, Omoniyi AT, Wu D, Kim H, Szeto HH. Cardiovascular and metabolic responses to two receptor selective opioid agonists in pregnant sheep. Am J Obstet Gynecol 1998;178:397-401.

Kett A, Omonyi A, Kim H, Olariu N, Wu D, Szeto HH, Clapp JF. Baroreceptor-mediated bradycardia but not tachycardia is blunted by intravenous m-opioid agonists. Am J Obstet Gynecol 1998;178:950-955.

Jeffrey A. Claridge, MD
Director of Research, Division of Trauma, Burns, and Critical Care
Assistant Professor
Department of Surgery
MetroHealth Medical Center
Case Western Reserve University School of Medicine
TEL: (216) 778-1005
FAX: (216) 778-1129

Biosketch

Alfred F. Connors, Jr., M.D.
Chair, Department of Medicine
Case Western Reserve University at
MetroHealth Medicial Center
Charles H. Rammelkamp Jr. Professor of Medicine
Case Western Reserve University School of Medicine
TEL: (216) 778-8266
FAX: (216) 778-5823

Biosketch
Curriculum Vitae

Research Interest(s)
Evaluation & measurement of patient outcomes, determining effectiveness of therapy, devices & processes of care, medical decision making, management of the seriously ill, and cost-effectiveness analysis.

Selected Publications
Stukenborg GJ, Wagner DP, Connors AF Jr. A comparison of two comorbidity measures with and without information from prior hospitalizations. Medical Care, 2001;39;727-739. Go to Publication

Arseneau KO, Cohn SM, Comminelli F, Connors AF Jr. Cost-utility of initial medical management for Crohn’s disease perianal fistulae. Gastroenterology 2001;120:1640-1656. Go to Publication

Rose JH. O`Toole EE. Dawson NV. Thomas C. Connors AF Jr. Wenger N. Phillips RS. Hamel MB. Reding DT. Cohen HJ. Lynn J. Generalists and oncologists show similar care practices and outcomes for hospitalized late-stage cancer patients. Medical Care. 2000;38:1103-1118. Go to Publication

Johnston KC, Connors AF Jr, Wagner DP, Haley EC Jr. Risk adjustment effect in stroke clinical trials. Stroke. 2004;35:43-45 Go to Publication

Stukenborg GJ, Wagner DP, Harrell FE, Oliver MN, Kilbridge K, Lyman J, Einbinder J, Connors AF. Hospital discharge abstract data on comorbidity improved the prediction of death among patients hospitalized with aspiration pneumonia. J Clin Epidemiol 2004; 57: 522-532. Go to Publication

Otto Costantini, M.D.
Assistant Professor of Medicine
Director, Arrhythmia Prevention Center
Director, Clinical Trials Unit
TEL: (216) 778-8765
FAX: (216) 778-392


Research Interest(s)
Prediction and prevention of sudden cardiac death. Risk stratification of congestive heart failure patients for ventricular arrhythmias. Outcomes and quality of life of patients with CHF and ventricular arrhythmias. Triggers of ventricular tacharrhythmias in patients at risk.

Selected Publications
Costantini O, Rosenbaum DS. Can sudden cardiac death be predicted from the T wave of the ECG? PACE 2000;23:14071416.

Quan KJ, Lee JH, Costanini et al. Favorable results of ICD implantation in patients older than 70. Ann Thorac Surg 1997;64:1713-1717.

Costantini O, Huck K, Carlson MD et al. Impact of a guideline based disease management team on outcomes of hospitalized patients with congestive heart failure. Arch Intern Med 2001;161:177-185

Graham Creasey, MD, FRCSEd
Associate Professor
Dept of Physical Medicine & Rehabilitation
Case Western Reserve University
Attending Physician
Dept of Physical Medicine & Rehabilitation
MetroHealth and VA Medical Centers
Principal Investigator
Functional Electrical Stimulation Center
TEL: (216) 778-5807, (216) 778-3472
FAX: (216) 778-1653


Curriculum Vitae
Functional Electrical Stimulation Center
PM&R, MetroHealth Medical Center

Research Interest(s)
Dr. Creasey studies the use of electrical stimulation to restore bladder, bowel, and sexual function following spinal cord injury, and the effects of these interventions on quality of life and costs.

Selected Publications
Lee YH, Creasey GH. Self-controlled dorsal penile nerve stimulation to inhibit bladder hyperreflexia in incomplete spinal cord injury: a case report. Arch Phys Med Rehabil. 2002 Feb;83(2):273-277. Go to Publication

Creasey GH, Dahlberg JE. Economic consequences of an implanted neuroprosthesis for bladder and bowel management. Arch Phys Med Rehabil. 2001 Nov;82(11):1520-1525. Go to Publication

Creasey GH, Grill JH, Korsten M, Betz R, Anderson R, Walter J. An implantable neuroprosthesis for restoring bladder and bowel control to patients with spinal cord injuries: a multicenter trial. Arch Phys Med Rehabil. 2001 Nov;82(11):1512-1519. Go to Publication

Gustafson KJ, Creasey GH & Grill WM. A catheter-based method to activate urethral sensory nerve fibers. Journal of Urology 170(1):126-129, 2003 Go to Publication

Creasey GH, Kilgore KL, Brown-Triolo DL, Dahlberg JE, Peckham PH, Keith MW. Reduction of costs of disability using neuroprostheses.Assist Technol. 2000;12(1):67-75. Go to Publication

Barbara Cromer, M.D.
Professor, Department of Pediatrics
Director, Adolescent Medicine, Department of Pediatrics
MetroHealth Medical Center
Case Western Reserve University
TEL: (216) 778-2643

Curriculum Vitae

Research Interest(s)
Dr. Cromer`s research currently is on different hormonal forms of birth control and bone density. Her staff is comparing bone thickness in adolescent girls who select either Depo-Provera (an injection ) or the birth control pill. They will also compare bone density of girls not using birth control. Preliminary findings suggest that bones may thin with the use of Depo-Provera.

Selected Publications
Cromer BA, Stager MM. Research articles published in Journal of Adolescent Health: a two-decade comparison. J Adolesc Health. 2000 Nov;27(5):306-313.

Stager MM, Cromer BA. Management of clinical side effects of DMPA. J Pediatr Adolesc Gynecol. 2000 Aug;13(3):147-149.

Valencia LS, Cromer BA. Sexual activity and other high-risk behaviors in adolescents with chronic illness: a review. J Pediatr Adolesc Gynecol. 2000 May;13(2):53-64.

Cromer BA, Schoenbachler R, Vesha K, Davis J, Wescher J: Compliance in adolescents using different forms of hormonal contraception. Sexological Review 1998; 5:129-42.

Cromer BA, Berg-Kelly K, van Groningen JP, Seimer BS, Ruusavaara L. Depot medroxyprogesterone acetate (Depo-Provera) and levonorgestrel (Norplant) use in adolescents among clinicians in Northern Europe and the United States. J Adolesc Health 1998;22:74-80.

Pamela B. Davis, M.D., Ph.D.
Professor of Pediatrics, Physiology & Biophysics,
and Molecular Biology & Microbiology
Department of Medicine,
Veterans Administration Medical Center
Arline H. and Curtis F. Garvin, M.D., Research Professor
Senior Associate Dean for Research
Case Western Reserve University
TEL: (216) 368-4370
FAX: (216) 368-4223

Web Page
Curriculum Vitae

Research Interest(s)
The goal of our laboratory is to understand the pathophysiology of cystic fibrosis (CF), a common fatal genetic disease, and to ultimately to ameliorate or cure it. CF is caused by defects in a gene that encodes a chloride channel, CFTR, but the patients succumb to pulmonary infection and inflammation. One line of work in our lab investigates how dysfunction of CFTR leads to infection and particularly the excess inflammatory response that characterizes the CF lung disease. In cell and animal models, CF cells and CF mice have excessive cytokine responses to bacterial stimulation, which contributes to lung damage. We study the mechanism of this excessive response and how to prevent it without impairing host defenses. We have shown previously that high dose ibuprofen ameliorates the excessive inflammation, and it is our current working hypothesis that the mechanism of this effect is by binding to PPAR *, a nuclear receptor which can interact with the pro inflammatory transcription factor NF *B, in reciprocal fashion. Ultimately, we will build upon our findings in cell and animal models for design of a clinical trial.

A second line of work is to devise means of delivering the corrective CFTR gene to the airways of patients with CF. We have constructed DNA nanoparticles that consist of plasmid DNA compacted with polylysine and stabilized with polyethylene glycol, in which the smallest diameter is less than that of the nuclear pore. This small size allows nuclear access in nondividing cells. These nanoparticles can transfect airway epithelium in vivo in CF mice to a sufficient extent to correct not only the CF chloride transport defect but also some of its downstream consequences. In addition, these nanoparticles seem to be quite nontoxic, and they can be dosed repeatedly without decrement in effect. A single dose Phase I clinical trial in the nose of human patients with CF was completed, with the result that 8 of 12 subjects had improvement in chloride transport, with no adverse effects attributable to the drug. Current work is investigating potential improvements in the DNA nanoparticles (including targeting and improvement of the plasmid construct), aerosolization of the particles for pulmonary treatment, and extension of the molecular targets to delivery of siRNA directed against respiratory viruses.

Selected Publications
Ziady, AG, Gedeon, CR. Miller, T, Quan, W. Payne JM, Hyatt SL, Fink TL, Muhammed O, Oette S, Kowalczyk,T. Pasumarthy M, Moen, RC, Cooper MC, and Davis, P.B. Transfection of Airway Epithelium by Stable PEGylated Poly L lysine DNA Nanoparticles In Vivo, Mol Ther. 8(6):936 47, 2003.

Ziady AG, Gideon CR, Muhammad O, Stillwell V, Oette SM, Fink TL, Quan W, Kowalczyk TH, Hyatt SL, Peischl A, Seng JE, Moen RC, Cooper MJ, and Davis PB. Minimal Toxicity of Stabilized compacted DNA nanoparticles in the murine lung. Mol Ther. 8(6):948 56, 2003.

van Heeckeren AM Schluchter, MD Davis, PB Role of Cftr Genotype in the Response to Chronic Pseudomonas aeruginosa Lung Infection in Mice Am J. Physiology:Lung Cell and Molecular Physiology 2004 ;287(5):L944 52.

Neal V. Dawson, M.D.
Professor of Medicine, Epidemiology and Biostatistics
MetroHealth Medical Center Staff Since 1982
Center for Health Care Research and Policy
TEL: (216) 778-3901
FAX: (216) 778-3945


Biosketch
Curriculum Vitae

Research Interest(s)
Dr. Dawson is a specialist in general internal medicine and works in the MetroHealth Primary Care Internal Medicine Clinic (Firms). He has published on the use of Firms for research, especially in health services. He recently completed a Firm trial on alcohol screening and management in a primary care setting. He is currently looking at predictors of alcohol use among nonaddicted Hepatitis C patients. In addition he has considerable experience in the conduct of large studies and in multvariable analyses of large databases.

Selected Publications
Murray PK, Love TE, Dawson NV, Thomas CL, Cebul RD. Rehabilitation services following the implementation of the nursing home prospective payment system: Differences related to patient and nursing home characteristics. Medical Care 2005; 43:1109 15.

Bailit JL, Love TE, Dawson NV. Quality of obstetric care and risk-adjusted primary cesarean rates. Am J Ob Gyn 2006;194:402-7.

Bailit JL, Schulkin J, Dawson NV. Risk-adjusted cesarean rates: What risk factors for cesarean delivery are important to practicing obstetricians? Am J Reprod Med 2006; (in press).

Lindstrom HA, Smyth KA, Sami SA, Dawson NV, Patterson MB, Bohinc JH, Post SG, Barber MJ, Ollerton S, Singer M, Whitehouse PJ. Medication use to treat memory loss in dementia: perspectives of people with dementia and their caregivers. Dementia 2006;5(1):27-50.

Stoller EP, Hund AJ, Webster NJ, Blixen CE, Perzynski AT, McCormick RA, Kanuch SW, Dawson NV. Alcohol consumption within the context of hepatitis C: a qualitative study of non-problematic drinkers. Alcohol and Alcoholism 2006; 41(5):546-552.

Dorr G. Dearborn, Ph.D., M.D.
Professor of Pediatrics
Mary Ann Swetland Professor of
Environmental Health Sciences
Case Western Reserve University


Research Interest(s)
Primary Research Interest-
Extensive Mold Exposure: Health Effects for Infants and Children
Acute Pulmonary Hemorrhage in Infants:
Over the past ten years, there have been 38 infants with acute pulmonary hemorrhage cared for at our pediatric hospital; five infants have died. The initial case-control study of the first 10 infants, led by the CDC, found an association with exposure to moldy home environments. Additional experience supports the association since 88% of the total 38 infants have come from water-damaged home environments containing Stachybotrys chartarum and other fungi. Removing these infants from their original home environments resulted in a 17-fold decrease in re-bleeding (Dearborn, et al., Pediatrics, 110:627,2002). The association is further supported by infant animal studies. Additional factors of environmental tobacco smoke and bacterial endotoxin are being considered.

Related Research Projects-
1. Continued collection and analysis of acute respiratory tract samples from infants presenting with acute pulmonary hemorrhage.
2. Further development of quantitative PCR and immunological biomarkers to document acute fungal exposure in infants and children.
3. Extension of our acute fungal exposure model in infant rats to a more chronic, low level exposure.
4. Kinetics of mycotoxin and proteinase release from fungal spores.

Mold-related Health Effects in Children:
A. Children of families who have left their homes because of adverse health effects apparently due to extensive mold contamination have been seen for clinical and psychometric evaluation. Initial, uncontrolled observations note that most laboratory tests including IgG fungal serologies are seldom abnormal. Symptom profiles obtained by retrospective questionnaire reflect significant reductions of most general health and respiratory symptoms after the children are out of the moldy environments. Children exposed prior to six years of age appear to have an increased incidence of language deficits.

Related Research Projects-
1. Case-control study of infants and siblings of mold exposure and possible neurotoxicity as seen by Visual Contrast Sensitivity and language psychometric evaluation.

B. Children living in damp, moldy home environments are at-risk of developing respiratory illness, both acutely and longer term. In a recently completed study supported by US HUD and US EPA (Cuyahoga County Urban Mold and Moisture Project, UMMP), explored the relationship between mold, moisture, asthma triggers and the respiratory health of children living in inner city neighborhoods throughout Greater Cleveland. Clinical and environmental assessments before and after targeted remediation found significant improvement in moderately severe asthmatic children compared to randomized controls whose homes were not remediated (decrease in symptom score (Am Acad Ped Asthma Health Survey) p<0.006 and symptom days p<0.003). The home intervention group also had a lower rate of exacerbations requiring hospitalization or an emergency room visit compared to control asthmatics (1/29 vs. 11/33, respectively, p=.003). Environmental assessments found a significant decrease in the visual mold (p=0.0035) and the ratio of indoor/outdoor mold species (p=0.049) in remediated versus control homes. The large data base generated by the extensive semi-quantitative culturing of fungi and the quantitative PCR measurements of 33 fungal species continues to be analyzed. While the significance of the UMMP study is limited due to the small number of families and homes investigated, the observed clinical improvements are very encouraging and underline the need to expand on these observations in larger studies in cooperation with other pulmonary centers.

Selected Publications
Dearborn, DG, Smith, PG, Dahms, BB, Allan, TM, Sorenson, WG, Montana, E, Etzel, RA, Clinical profile of thirty infants with acute pulmonary hemorrhage in Cleveland. Pediatrics, 110:627-637, 2002.

Yike, I, and Dearborn, D.G. Pulmonary effects of Stachybotrys chartarum in animal studies. In: Advances in Applied Microbiology, Sick Building Syndrome, D. Strauss (ed), Elsevier Inc, 2004, p.241-273.

Vesper, SJ, Varma, M, Wymer, LJ, Dearborn, DG, Sobolewski, J, Haugland, RA. Quantitative polymerase chain reaction analysis of fungi in dust from homes of infants who developed idiopathic pulmonary hemorrhaging, J Occup Environ Med, 46:596-601, 2004

Adrienne T. Dennis, Ph.D.
Staff Scientist
Rammelkamp Center for Education & Research
MetroHealth Medical Center
TEL: (216) 778-8667
FAX: (216) 778-8282


Research Interest(s)
Molecular mechanisms involved in the processing of the cardiac potassium channel HERG within the cell and how this changes in hereditary or acquired (drug-induced) long QT syndrome (LQT2).

Selected Publications
Ficker E., Kuryshev Y.A., Dennis A.T., Obejero-Paz C., Wang L., Hawryluk P., Wible B.A., Brown A.M. Mechanisms of Arsenic-Induced Prolongation of Cardiac Repolarization. Mol. Pharmacol. 66:33-44, 2004. Go to Publication

Ficker E., Dennis A.T., Wang L., Brown A.M. Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG. Circ. Res. 92:e87-100, 2003. Go to Publication

Ficker E, Dennis AT, Obejero-Paz CA, Castaldo P, Taglialatela M, Brown AM. Retention in the endoplasmic reticulum as a mechanism of dominant-negative current suppression in human long QT syndrome. J. Mol. Cell. Cardiol. 2000;32:2327-2337. Go to Publication

Ficker E, Thomas D, Viswanathan PC, Dennis AT, Priori SG, Napolitano C, Memmi M, Wible B A, Kaufman ES, Iyengar S, Schwartz PJ, Rudy Y, Brown AM. Novel characteristics of a misprocessed mutant HERG channel linked to hereditary long QT syndrome. Am. J. Physiol. 2000;279:H1748-H1756 Go to Publication

Isabelle Deschênes, Ph.D.
Assistant Professor of Medicine
Case Western Reserve University
Heart & Vascular Research Center
MetroHealth Medical Center
TEL: (216) 778-5166
FAX: (216) 778-1261

Curriculum Vitae

Research Interest(s)
Potentially lethal arrhythmias in rare inherited syndromes (idiopathic ventricular fibrillation) and more common, acquired heart diseases (cardiac hypertrophy and failure) have been associated with an imbalance of depolarizing (Na current) and repolarizing (Ito) current early in the ventricular action potential and a down regulation of Ito respectively. Our previous work demonstrated that cardiac Ito and INa form a macromolecular complex. Delineation of the molecular basis of this macromolecular complex formed by Ito and INa is essential for an accurate understanding of cardiac ventricular depolarization and repolarization and its derangements that are associated with lethal ventricular arrhythmias.

In this project we combine the use of gene silencing (RNA interference) and Fluorescence Resonance Energy Transfer (FRET) to electrophysiological recordings to elucidate the molecular basis, structure and function of this macromolecular complex formed between channel subunits that comprise voltage-dependent Na channels and the transient outward K current Ito. This work will have broad appeal and important implications for cellular electrophysiology of cardiac muscle and its derangements in both congenital and acquired diseases associated with potentially lethal cardiac arrhythmias.

Anthony DiMarco, M.D.
Professor
Functional Electrical Stimulation Center
TEL: (216) 778-3906
FAX: (216) 778-4321



Research Interest(s)
The purpose of Dr. DiMarco`s studies is to restore respiratory muscle function in patients with spinal cord injury. FES is developing systems for electrical activation of the inspiratory muscles to maintain full-time ventilatory support in patients with ventilator-dependent tetraplegia and electrical activation of the expiratory muscles to provide an effective cough mechanism in patients with expiratory muscles paralysis.

Selected Publications
DiMarco AF. Neural prostheses in the respiratory system. J Rehabil Res Dev. 2001 Nov-Dec;38(6):601-607.

DiMarco AF, Romaniuk JR, Supinski G, Kowalski KE. Effects of lung volume on parasternal pressure-generating capacity in dogs. Exp Physiol. 2000 May;85(3):331-337.

Stofan DA, Callahan LA, DiMarco AF, Nethery DE, Supinski GS. Modulation of release of reactive oxygen species by the contracting diaphragm. Am J Respir Crit Care Med. 2000 Mar;161(3 Pt 1):891-898.

Clark W. Distelhorst, M.D.
Professor of Medicine
Professor of Pharmacology
Charles S. Britton II Professor of Hematology/Oncology
Case Western Reserve University
TEL: (216) 368-4546
FAX: (216) 368-8919


Research Interest(s)
Research in the laboratory of Dr. Clark Distelhorst has two fundamental goals. One is to understand how glucocorticosteroid hormones (dexamethasone, prednisone) induce apoptosis in lymphocytes and the other is to understand how Bcl-2 inhibits apoptosis, emphasizing the role of Bcl-2 on the endoplasmic reticulum. Because glucocorticosteroid hormones induce apoptosis in young lymphocytes, glucocorticoid hormones have an important role in the treatment of a wide variety of lymphoid cancers. Understanding the mechanism of apoptosis induction by glucocorticoids will enable us to develop novel therapies and overcome resistance to glucocorticoid-induced apoptosis, while providing novel insight into a fundamentally important mechanism of apoptosis induction. Conversely, the primary action of Bcl-2 is to inhibit apoptosis. In this way Bcl-2 promotes cancer cell survival and inhibits cell killing by chemotherapeutic agents. The laboratory has many accomplishments. Using oligonucleotide microarrays, we have profiled the gene changes induced by dexamethasone in lymphoma cell lines and in primary murine thymocytes. This profile has uncovered many interesting genes and has set the stage for a number of projects in our lab. For example, we have recently discovered that the proapoptotic BH3-only protein Bim is induced by dexamethasone in normal primary thymocytes and in lymphoma cells. Thus, Bim is a glucocorticoid-induced “death gene”. As revealed by our microarray findings, a number of other interesting genes are induced by dexamethasone that may contribute to the life-death decision of cells treated with dexamethasone. On another front, our laboratory was the first, over ten years ago, to indicate that Bcl-2 works at the level of the endoplasmic reticulum to regulate calcium signals involved in mediating apoptosis.

Determining the effect of Bcl-2 on calcium signals is one of the highest priorities in our laboratory today. In addition, we are interested in the role of ER-localized Bcl-2 in regulating protein-protein interactions with other family members. Recently we have employed targeting sequences to direct Bcl-2 to either ER or mitochondria. Paradoxically we discovered that Bcl-2 targeted to the outer mitochondrial membrane induces apoptosis, whereas Bcl-2 targeted selectively to the ER is antiapoptotic.

Selected Publications
Thomenius MJ, Wang NS, Reineks EZ, Wang Z, and Distelhorst CW. Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3 only proteins. J. Biol. Chem. 278:6243-6250, 2003

Wang Z, Malone MH, He H, McColl KS, Distelhorst CW. Microarray analysis uncovers the induction of the pro-apoptotic BH3-only protein Bim in multiple models of glucocorticoid induced apoptosis. J. Biol. Chem. 278:23861-23867, 2003

Wang Z, Malone MH, Thomenius MJ, Zhong F, Xu F, Distelhorst CW. Dexamethasone-induced gene 2 (dig2) is a novel prosurvival stress gene induced rapidly by diverse apoptotic signals. J Biol Chem 278:27053-27058, 2003

Chen R, Valencia I, Zhong F, McColl KS, Roderick HL, Bootman MD, Berridge MJ, Conway SJ, Holmes AB, Mignery GA, Velez P, Distelhorst CW. Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate. J Cell Biol 166:193-203, 2004

Malone M, Wang Z, Distelhorst CW. The glucocorticoid-induced gene tdag8 encodes a pro-apoptotic G protein-coupled receptor whose activation promotes glucocorticoid-induced apoptosis. J Biol Chem 279:52850-52859, 2004

Kevin Donahue, M.D.
Associate Professor of Medicine
Case Western Reserve University
TEL: (216) 778-5998
FAX: (216) 778-1261

Curriculum Vitae

Selected Publications
Donahue JK, Bauer A, Kikuchi K, Sasano T. Modification of cellular communication by gene transfer. Annals of the New York Acad Sci 1047:157-165 2005.

Donahue JK, Kikuchi K, Sasano T. Gene Therapy for Cardiac Arrhythmias. Trends in Cardiovascular Med 15:219-224 2005.

Donahue JK. Gene Therapy for Cardiac Arrhythmias. Annals of the New York Acad Sci 1015:332-338 2004.

Douglas Einstadter, M.D, M.P.H.
Professor of Medicine, Epidemiology and Biostatistics
Member, Center for Health Care Research and Policy
Staff Physician, Department of Medicine
TEL: (216) 778-3901
FAX: (216) 778-3945

Biosketch
Curriculum Vitae

Research Interest(s)
Use of large databases in health services research; Application of Geographic Information Systems (GIS) to health services research; Use of informatics to improve quality of care.

Selected Publications
Baker DW, Einstadter D, Husak SS, and Cebul RD. Trends in postdischarge mortality and readmissions: has length of stay declined too far? Arch Intern Med. 2004 Mar 8;164(5):538-44

Baker DW, Einstadter D, Thomas C, Cebul RD Mortality trends for 23,505 Medicare patients hospitalized with heart failure in Northeast Ohio, 1991 to 1997. Am Heart J. 2003 Aug;146(2):258-64.

Yuan Z, Dawson N, Cooper GS, Einstadter D, Cebul R, Rimm AA. Effect of Alcohol-related Disease on Hip Fracture and Mortality: A Retrospective Cohort Study of 876,337 Hospitalized Medicare Beneficiaries. Am J Public Health 2001;91:1089-1093.

Yuan Z, Cooper GS, Einstadter D, Cebul RD, Rimm AA. The Association Between Hospital Type and Mortality and Length of Stay. Medical Care 2000;38:231-245.

Hoffman RM, Einstadter D, Kroenke K. Evaluating Dizziness. Am J. Med. 1999;107:468-478.

Ashraf El-Meanawy, M.D., Ph.D.
Assistant Professor
Department of Medicine, MetroHealth Medical Center
Case Western Reserve University
Renal Research Center
TEL: (216) 778-1087
FAX: (216) 778-4321



Research Interest(s)
Dr. El-Meanawy investigates the genetics of end stage renal disease (ESRD). He applies molecular genetics techniques to identify genes that are involved in the development or conferring susceptibility to end stage renal disease. This laboratory uses a genetically susceptible animal model that develops spontaneous progressive renal failure. Dissecting the gene expression patterns in the diseased and comparing that to the healthy control animals should allow the lab staff to identify genes involved in the development of ESRD. Further study of these genes can lead to development of novel diagnostic and therapeutic modalities.

Selected Publications
Schelling JR, El-Meanawy MA, Barathan S, Dodig T, Iyengar SK, Sedor JR. Generation of kidney transcriptomes using serial analysis of gene expression. Exp Nephrol. 2002;10(2):82-92.

El-Meanawy MA, Schelling JR, Pozuelo F, Churpek MM, Ficker EK, Iyengar S, Sedor JR. Use of serial analysis of gene expression to generate kidney expression libraries. Am J Physiol Renal Physiol. 2000 Aug;279(2):F383-392

Robert B. Elson, M.D., M.S.
Senior Informatics Researcher
Center for Health Care Research & Policy
MetroHealth Medical Center
TEL: (216) 778-3916
FAX: (216) 778-3945

Curriculum Vitae

Selected Publications
Elson, R.B. Outpatient Prescription History in the Hospital: The Opportunity and Challenge of RxHub MEDS. Part I: Background and Benefits. RxHub White Paper. February 2004.

Teich, J., Hale, P., Elson, R., Frisse, M., Glaser, J. Electronic Prescribing: Toward Maximum Value and Rapid Adoption. eHealth Initiative. Washington, D.C., 4/14/04 .

Elson, R.B. Web-based systems rejuvenate physician-patient communications. Group Practice Journal, May 2001:43-45.

Eckhard Ficker, Ph.D.
Jr. Staff Scientist
TEL: (216) 778-8977
FAX: (216) 778-8282

Curriculum Vitae

Research Interest(s)
Cellular pathophysiology of LQT2/HERG K+ channels

Selected Publications
FICKER, E., DENNIS, A.T., OBEJERO-PAZ, C.A., CASTALDO, P., TAGLIALATELA, M., BROWN, A.M. Retention in the endoplasmic reticulum as a mechanism of dominant-negative current suppression in human long QT syndrome. J. Mol. Cell. Cardiol., 32, 2327-2337, 2000

FICKER, E., JAROLIMEK, W., KIEHN, J., BAUMANN, A., BROWN, A.M. Molecular determinants of dofetilide block of HERG potassium channels. Circ. Res., 82, 386-395, 1998

FICKER, E., TAGLIALATELA, M., WIBLE, B.A., HENLEY, C.M., BROWN, A.M. Spermine and Spermidine as gating molecules for inward rectifier K+ channels. Science, 266, 1068-1072, 1994

Robert S. Finkelhor, M.D.
Director, Non-Invasive Cardiology
Associate Professor
Case Western Reserve University
TEL: (216) 778-5270


Research Interest(s)
General Cardiology,
Non-Invasive Cardiology,
Cardiac Imaging

James Finley, M.D., Ph.D.
Physician, Pulmonary & Critical Care Medicine
MetroHealth Medical Center
Associate Professor
Case Western Reserve University
TEL: (216) 778-2927
FAX: (216) 778-3240


Research Interest(s)
COPD
Critical Care Medicine

Sharon Groh-Wargo, PhD, RD, LD
Assistant Professor
Departments of Pediatrics and Nutrition
Case Western Reserve University
Neonatal Nutritionist
Department of Pediatrics
MetroHealth Medical Center
TEL: (216) 778-5902, (216) 778-5909
FAX: (216) 778-3252


Research Interest(s)
Neonatal nutrition, growth and body composition

Selected Publications
Ryan AS, Montalto MB, Groh-Wargo S, Mimouni F, Sentipal-Walerius J, Doyle J, Siegman JS, Thomas AJ. Effect of DHA-containing formula on growth of preterm infants to 59 weeks postmenstrual age. Am J Hum Biol 11: 457-467, 1999.

Groh-Wargo S, Cox JH, Thompson M (eds). Nutritional Care for High Risk Newborns, 3rd Revised Edition. Precept Press, Chicago, 2000.

O`Connor DL, Hall R, Adamkin D, Auestad N, Castillo M, Connor WE, Connor SL, Fitzgerald K, Groh-Wargo S, et al. Growth and development in preterm infants fed long-chain polyunsaturated fatty acids: A prospective randomized control trial. Pediatrics 108: 359-371, 2001.

O`Connor DL, Jacobs J, Hall R, Adamkin D, et al, Groh-Wargo S, et al. Growth and development of premature infants fed predominantly human milk, predominantly premature infant formula, or a combination of human milk and premature formula. J Pediatr Gastroenterol Nutr 37:437-46,2003.

Diyana R. Gunawardena, M.D.
Geriatrics Physician
Assistant Professor
Case Western Reserve University
TEL: (216) 778-2431


Research Interest(s)
Heart Failure, Geriatrics

Kenneth J. Gustafson, Ph.D.
Staff Scientist, Dept. of Orthopaedics
MetroHealth Medical Center
Department of Biomedical Engineering
Neural Engineering Center
Case Western Reserve University
TEL: (216) 778-3801


Research Interest(s)
Research interests focus on understanding the systems-level neurophysiology and neural control of pelvic functions, and using this information to design and develop neural prostheses that interface with native spinal neural circuitry and restore physiologic function. Bladder dysfunction can have a devastating clinical impact. Therefore my efforts include developmental and pre-clinical studies to translate research advances into clinical implementation at the earliest opportunity. Current projects in both animal models and individuals with neural dysfunction include peripheral activation of spinal circuits to activate and inhibit bladder function, development of an implanted neural prosthesis able to selectively record and stimulate neural pathways and restore bladder function (a bladder pacemaker), neural recording of organ activity as a control source for closed-loop neural prostheses, commercial activities to translate research discoveries into clinical practice, combining myoplasty and neuromuscular stimulation to harness skeletal muscle power for cardiac assist and rehabilitation applications, and exploring neural anatomy to improve peripheral nerve electrode design.

Selected Publications
Gustafson KJ, Creasey GH and Grill WM. A urethral afferent mediated excitatory bladder reflex exists in humans. Neuroscience Letters, 360(1-2): 9-12, 2004.

Gustafson KJ, Creasey GH and Grill WM. A Catheter Based Method to Activate Urethral Sensory Nerve Fibers. Journal of Urology, 170(1):126-129, 2003.

Gustafson, KJ, JD Sweeney, J Gibney, LA Fiebig-Mathine. Skeletal muscle ventricle pressure-volume properties conform to dynamic and static conditioning. Annals of Thoracic Surgery. 76(3):828-835, 2003.

Subrata Haldar, Ph.D.
Staff Scientist, Research, MetroHealth Medical Center
Associate Professor, Dept. of Pharmacology, Case Western Reserve University
Member, Cell Death & Proliferation Program, Case Comprehensive Cancer Center
TEL: (216) 778-1167, (216) 778-2237
FAX: (216) 778-4321



Research Interest(s)
The long-term goal of Dr. Haldar`s research is apoptosis (cell suicide) inducing therapy that can be targeted for prevention of cancer. Cancer cells have growth advantage and it is becoming clear that they also have a death advantage. In tumors, cells that have adapted the ability to escape apoptosis (high resistance to cancer therapy) contribute to the net accumulation of tumor mass.

Selected Publications
Basu A and Haldar, S (2003) Identification of a novel bcl-xL phosphorylation site regulating the sensitivity of Taxol or 2-Methoxyestradiol induced apoptosis. 538:41-47.

Basu A, Das M, Qanungo S, Fax X-U, Dubois G and Haldar S (2002)Proteasomal degradation of human peptidyl prolyl isomerase pin 1-pointing phospho Bvl2 towards dephosphorylation. Neoplasia 4:218-227.

Haldar S, Basu A and Croce CM (1998) Serine-70 is one of the critical site necessary for drug induced Bcl2 phosphorylation in cancer cells. Cancer Res 58:1609-1615.

Qanungo S, Basu A, Das M and Haldar S (2002) 2-methoxyestradiol elicits mitochondria dependent apoptotic signaling in pancreatic cancer cells. Oncogene 21:4149-4157.

Haldar S, Jena, N and Croce CM (1995) Inactivation of Bcl2 by phosphorylation. Proc Natl Acad Sci USA 92: 4507-4511.

Joseph Hanna, M.D.
Director, Department of Neurology
MetroHealth Medical Center
Assistant Professor
Case Western Reserve University
TEL: (216) 778-3922


Research Interest(s)
GAINS Stroke Study
Citicoline Stroke Study
Vitamin Intervention for Stroke Prevention

Richard W. Hanson, Ph.D.
Professor of Biochemistry
Case Western Reserve University
Center for Metabolism and Nutrition
MetroHealth Medical Center
TEL: (216) 368-5302
FAX: (216) 368-4544

Web Page

Research Interest(s)
My research centers on three major themes: (1) a study of the factors involved in regulating the expression of the gene encoding the gluconeogenic enzyme P-enolpyruvate carboxykinase (PEPCK), (2) the metabolic impact of ablating or over expressing genes in target tissues of animals, and (3) the introduction of metabolic genes interest into the liver and related tissues to alleviate metabolic diseases.

Selected Publications
Perales, J.C., Grossman, G., Ferkol, T., Liu, G., Harpst, J., Oda, H. and Hanson, R.W. Biochemical and functional characterization of DNA complexes capable of targeting genes to the liver via the asialoglycoprotein receptor. J. Biol. Chem. 272, 7398-7407 (1997).

Savon, S.R., Hakimi, P., Crawford, D.R., Klemm, D.J., Gurney, A.L. and Hanson, R.A. The promoter regulatory regions of the genes for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) from the chicken and the rat have different species-specific roles in gluconeogenesis. J. Nutr. 127, 276-285 (1997).

Hanson, R.W.and Reshef, L. Regulation of P-enolpyruvate carboxykinase (GTP) gene expression. Annual Review of Biochemistry 66, (1997).

Michael Harrington, M.D.
Director of Palliative Care Clinical Services
Staff Physician, Division of General Medicine
Staff Physician, Jennings Center for Older Adults
TEL: (216) 778-5048


Research Interest(s)
End-of-life care
Advance Directives
Pain Management

Sylvie Hauguel-de Mouzon, Ph.D.
Professor of Reproductive Biology
Director, Molecular Biology Laboratory
OBGYN
Schwartz Center for Metabolism and Nutriton
TEL: (216) 778-3148, (216) 778 4262
FAX: (216) 778-1574


Research Interest(s)
The primary research interest of our group is in the mechanisms that regulate the growth of the fetus in utero in normal and pathological pregnancies. Over the last 10 years, our group has investigated the interactions between the maternal compartment and the feto-placental unit and addressed the molecular mechanisms that regulate maternal-fetal exchanges. Additionally, the regulatory mechanisms related to pathological pregnancies associated with diabetes, which often results in excessive fetal growth (macrosomia) have been studied. A strong emphasis has been put on the role of leptin during pregnancy. Earlier studies have shown that the placental controls fetal growth by producing hormones that modify fetal nutrition and fat accretion. Leptin is one of these hormones synthesized in high amounts by the placenta as well as by maternal and fetal adipose tissue.

OUR group has been instrumental in showing that the placenta synthesizes as much leptin as white adipose tissue and is a primary site for leptin action. We have characterized the main molecular pathways of placental leptin signaling. We have established that fetal plasma leptin is a marker of fat accretion in the human fetus. We have shown that diabetes modifies placental transcriptome in a way that favors fetal overgrowth and obesity, inducing chronic inflammation and increasing placental lipid strorage. This research is currently being extended into mechanisms of placental and fetal programming.

Current research projects focus on 4 main areas.
1. The origin of pregnancy-induced insulin resistance through longitudinal transcriptome/proteome studies of white adipose tissue and skeletal muscle analyzed at different stages of pregnancy.
2. Transcriptional regulation of placental leptin using in vitro models of trophoblast cells.
3. Mechanisms of leptin signaling in control of gene expression using microarray analysis
4. Regulation of fetal fat accretion in relation to placental structure and function. Resolution of these issues should help establish the yet missing link between modifications of maternal environment and the development of fetal obesity. These studies have important clinical implications as they relate to our understanding of the fetal origin of adult metabolic diseases (glucose intolerance, diabetes and obesity) and ultimately its prevention.

Selected Publications
Lepercq J, Guerre-Millo M, Vidal H, Cauzac M, Timsit J, Hauguel-de Mouzon S. 2001 Prenatal leptin production: Evidence that fetal adipose tissue produces leptin. J. Clin. Endocrinol. Metab. 86, 2409-2413

Boileau P, Cauzac C, Pereira MA, Girard J and Hauguel-de Mouzon S 2001. Dissociation between insulin-mediated signaling pathways and biological effects in placental cells : role of PKB and MAPKinase phosphorylation. Endocrinology 142, 3974-3979.

Kirwan JP, Hauguel-de Mouzon S, Lepercq J, Challier JC, Huston-Presley L, Friedman JE, Kalhan SC, and Catalano PM. 2002. TNF-alpha is a primary mediator of insulin resistance in human pregnancy. Diabetes 51, 2207-2213.

Grosfeld A, André J, Hauguel-de Mouzon, Berra E, J. Pouyssegur J. Guerre-Millo M. Hypoxia-inducible factor 1 HIF-1 transactivates the human leptin gene promoter 2002. J. Biol. Chem 277, 42953-42957.

Cauzac,M, D. Czuba , Girard J and S. Hauguel-de Mouzon (2003) Transduction of leptin growth signals in placental cells is independent of JAK-STAT activation Placenta 24, 378-384.

Radaelli, T., Varastehpour, A, Catalano P and S Hauguel-de Mouzon (2003). Gestational Diabetes induces placental genes for chronic stress and inflammatory pathways Diabetes 52 : 2951-2958.

Christina S. Hirsch, M.D., Ph.D.
Assistant Professor of Medicine
Division of Infectious Diseases
Case Western Reserve University
TEL: (216) 368-0441


Research Interest(s)
Primary: T-cell apoptosis and its mediators and mechanisms; with a focus on the contribution of both T-cell and macrophage apoptosis on host immune reactivity in HIV-infected and –uninfected persons with M. tuberculosis infection/disease.Secondary: Study of the immune response during human tuberculosis; particularly cytokine responses to M. tuberculosis and its components, and the role of blood monocytes in depressed anti-tuberculous defense mechanisms.

Selected Publications
Hirsch CS, Toossi Z, Vanham G, Johnson JL, Peters P, Okwera A, Mugerwa R, Mugeyenyi P, and Ellner JJ. Apoptosis and T-cell hyporesponsiveness in pulmonary tuberculosis. J Inf Dis 179:945-53. 1999.

Hirsch CS, Toossi Z, Johnson JL, Luzze H, Ntambi E, Peters P, McHugh M, Okwera A, Joloba M, Mugeyenyi P, Mugerwa RD, Terebuh P, and Ellner JJ. Augmentation of apoptosis and IFN-production at sites of active MTB infection in human tuberculosis. J Inf Dis, 183:779-88, 2001.

Ribeiro-Rodrigues R, Resende Co T, Ribeiro F, Palaci M, Johnson JL, Sá RT, Maciel EL, Pereira Lima FL, Dettoni V, Toossi Z, Boom WH, Dietze R, Ellner JJ, and Hirsch CS. Sputum cytokine levels in patients with pulmonary tuberculosis as markers of response to treatment. Clin Diag Lab Immunol, 9:818-23, 2002

John Hodgson, M.D.
Tenured Associate Professor of Medicine
Case Western Reserve University
Director, Invasive Cardiology
MetroHealth Medical Center
TEL: (216) 778-8213
FAX: (216) 778-3927

Web Page

Research Interest(s)
Investigational drugs affecting coronary physiology, investigational devises for coronary intervention, novel pharmacologic agents for acute coronary syndrome management, intravascular ultrasound, functional measures of coronary lesion severity.

Selected Publications
Christian Mueller, MD, John McB. Hodgson, MD, Christian Schindler, PhD, Andre´ P. Perruchoud, MD, Helmut Roskamm, MD, and Heinz J. Buettner, MD. Cost-Effectiveness of Intracoronary Ultrasound for Percutaneous Coronary Interventions. Am J Cardiol 2003;91:143–147.

Frey AW, Hodgson JMcB, Müller C, Bestehorn H-P, Roskamm H. Ultrasound-guided strategy for provisional stenting with focal balloon combination catheter: Results from the Randomised Strategy for Intracoronary Ultrasound-guided PTCA and Stenting (SIPS) trial. Circulation 2000;102:2497-2502.

Hodgson JMcB, King SB, Feldman T, Cowley MJ, Klein LW, Babb JD. SCAI statement on drug-eluting stents: Practice and health care delivery implications. Catheter Cardiovasc Interv 2003;58:397-399.

Sudha Iyengar, Ph.D.
Associate Professor
Department of Epidemiology and Biostatistics
Case Western Reserve University
TEL: (216) 778-8484



Research Interest(s)
Dr. Iyengar’s laboratory is involved in mapping disease genes utilizing state-of-the-art genetic technology with the ultimate goal of developing new therapies

Selected Publications
Schelling JR, El-Meanawy MA, Barathan S, Dodig T, Iyengar SK, Sedor JR. Generation of kidney transcriptomes using serial analysis of gene expression. Exp Nephrol. 2002;10(2):82-92.

Iyengar SK, Schelling JR, Sedor JR. Approaches to understanding susceptibility to nephropathy: From genetics to genomics. Kidney Int. 2002 Jan;61 Suppl 1:61-67.

Iyengar SK, Jacobs KB, Palmer LJ. Improved evidence for linkage on 6p and 5p with retrospective pooling of data from three asthma genome screens. Genet Epidemiol. 2001;21 Suppl 1:S130-135

Nancy Johnson, M.D.
Assistant Professor of Medicine
Director, Pacemaker Services
TEL: (216) 778-2249
FAX: (216) 749-3927


Research Interest(s)
Delayed afterdepolarizations, triggered activity .

Selected Publications
Johnson NJ, Danilo P, Wit AL, Rosen MR: Characterization of initiation and termination of catecholamine-induced triggered activity in atrial fibers of the coronary sinus. Circ 74(5):1168,1986.

Johnson NJ, Marchlinski FE: Arrhythmias induced by device antitachycardia therapy due to diagnostic nonspecificity. JACC. 18(5):1418,1991.

Johnson NJ: Inconsistent response to rapid atrial rhythms in a DDD pacemaker with the fallback feature. PACE,18:1457,1995.

David C. Kaelber, MD, PhD, MPH
Assistant Professor of Medicine and Pediatrics
Case Western Reserve University
Div. of Internal Medicine and Pediatrics
Chief Medical Informatics Officer
MetroHealth Medical Center
TEL: (216) 778-3680
FAX: (216) 778-1384


Biosketch

Research Interest(s)
1. Use of technology in the practice and teaching of medicine.
2. Development of Med-Peds (combined Internal Medicine and Pediatrics) as a profession.
3. Asthma in children and adults.
4. Cardiac imaging.

Selected Publications
KAELBER DC. The Next Generation EKG - In Vivo Demonstration of Noninvasive Electrocardiographic Imaging During Normal Sinus Rhythm. Proceedings of the 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. San Francisco CA. 2004. (Poster)

W Cull, KAELBER DC, T Melgar, BD Kan and JK Chamberlain. Training Experiences of Combined Internal Medicine and Pediatrics Residents. Pediatric Academic Societies. 2004. (Poster)

KAELBER D, JA Nelson, LF Strauss, E West, and IA Gilbert. Decline in Asthmatics` Personal Best FEV1 is not Associated with Progressive Obstruction as Measured by Spirometry. American Thoracic Society. 2003. (Poster)

KAELBER DC, S Grove, C Dziedzina, R Cohen, D Bar-Shain and M Richard. A Pediatric PDA (Personal Digital Assistant) Program for Residents. Pediatric Academic Societies. 2003. (Poster)

KAELBER DC, SB Bierer, and JR Carter. A Web-based Clinical Curriculum on the Cardiac Exam. Academic Medicine. 76(5):448-449. 2001. (http://mediswww.cwru.edu/cardiacexam) Go to Publication

Robert C. Kalayjian, M.D.
Assistant Professor of Medicine,
Case Western Reserve University
Director,
Infectious Diseases Clinic,
MetroHealth Medical Center
TEL: (216) 778-5136


Research Interest(s)
"I am interested in clinical research that might translate to insights in pathogensis and basic disease mechanisms. I am currently the protocol chair of an Adult AIDS Clinic Trials Group, multi-center, prospective cohort study of age-differentiated HIV-infected subjects, to examine the immune and virologic basis of age-related accelerated HIV-disease progression. In this 192 wk study we are examining immune and responses to highly active antiretroviral therapy including advanced flow cytometry, responses to vaccination and skin testing, lymphoproliferative assays, and changes in markers of thymic activity.

I have received an institutional initiative grant to perform microarray analyses on some of these patients, in an effort to identify gene expression that may be associated with homeostatic proliferation of naïve T cells.

The CRSP program has allowed me to better understand issues in study design and analysis and has been a tremendous resource towards my development as a clinical researcher."

Selected Publications
Burke DG, Leonard DGB, Imperiale TF, Karaman B, Shick E, Kalayjian RC. The utility of clinical and radiographic features in the diagnosis of cytomegalovirus central nervous system disease in AIDS patients. Molec Diag 1999; 4:37-43.

Jayasekara D, Aweeka FT, Rodriguez R, Kalayjian RC, Humphreys MH, Gambertoglio JG. Antivirals in renal failure. J Acquir Immun Def Synd and Retroviruses 1999;21:384-95.

Barditch-Crovo P, Noe D, Skowran G, Lederman M, Kalayjian RC, Borum P, Buir R, Towe WB, Goldberg D, Lietman P. A phase I/II evaluation of oral L-2-oxothiazolidine-4-carboxylic acid in asymptomatic patients infected with human immunodeficiency virus. J Clin Pharmacol 1998;38:357-363.

Burke DG, Kalayjian RC, Vann VR, Medreperla SA, Shick He, Leonard DGB. Polymerase chain reactiondetection and clinical significance of varicella zoster virus in the cerebrospinal fluid from HIV-infected patients. J Infect Dis 1997;176:1080-64.

Smith MC, Austen JL, Carey JT, Emancipator SN, Herbener T, Gripshover B, Mbanefo C, Phinney M, Rahman M, Salata RA, Weigel K, Kalayjian RC. Prednisone improves renal function and proteinuria in human immunodeficiency virus-associated nephropathy. Am J Med 1996;101:41-48.

Satish C. Kalhan, M.D.
Professor, Department of Pediatrics
Director, Robert Schwartz, M.D. Center for Metabolism & Nutrition
MetroHealth Medical Center
Case Western Reserve University
TEL: (216) 778-8643



Research Interest(s)
The metabolic adaptive responses of the mother during normal pregnancy, which contribute to normal fetal growth and the transition of the normal fetus to extrauterine life, is the major focus of our group. Innovative stable isotopic tracers and gas chromatography-mass spectrometry methods are utilized in combination with indirect respiratory calorimetry in order to quantify metabolism in vivo. Perturbations in metabolism, e.g. as a consequence of maternal diabetes or intrauterine growth retardation, are being examined. Recent studies from our group have shown that, in human pregnancy, changes in maternal glucose and fat metabolism occur in parallel with the increasing fetal demands, while nitrogen conservation appears to occur early in gestation in anticipation of the fetal needs. Other studies, in collaboration, are examining the role of maternal insulin resistance on maternal protein metabolism and fetal growth, the significance and mechanism of insulin resistance in puberty, and the consequence of insulin resistance on muscle protein metabolism in liver disease. The ultimate goal of these studies is to develop effective intervention strategies for optimal clinical and nutritional management of these physiological and pathophysiological states.

The mechanism of reduced environmental oxygen and hypoxemia on intrauterine growth restriction is being examined in the rat model of pregnancy. The alterations in transport of nutrients, e.g. glucose and amino acids, from the mother to the fetus are quantified using in vivo and in vitro methods.

Selected Publications
Kalhan SC, Parimi P, Van Beek R, Gilfillan C, Saker F, Gruca L, Sauer PJJ: Estimation of gluconeogenesis in newborn infants. Am J Physiol 281:E991-E997, 2001.

Kalhan SC, Mahajan S, Burkett E, Reshef L, Hanson RW: Glyceroneogenesis and the source of glycerol for hepatic triacylglycerol synthesis in humans. J Biol Chem 276: 12928-12931, 2001.

Kalhan S, Rossi K, Gruca L: Decompensation of leucine nitrogen turnover in gestational diabetes. Diabetes Care 23:1033-4, 2000.

Kalhan S, Peter-Wohl S: Hypoglycemia: What is it for the neonate? Am J Perinatol 17:11-18, 2000.

Kalhan S: Protein metabolism in human pregnancy. Am J Clin Nutr 71:1249S-1255S, 2000.

Perry Kannan, Ph.D.
Staff Scientist (Associate Professor)
TEL: (216) 778-1156
FAX: (216) 778-7554


Research Interest(s)
My laboratory is focused on delineating the molecular events of oncogenesis, especially the pivotal roles played by transcription factors. We have taken transcription factor AP-2 as a model system. Deregulation of AP-2 has been implicated in many carcinogenic events including Ras-oncogenic signal transduction pathway, breast cancer, adenocarcinoa and melanoma. We are particularly interested in two of these carcinogenic events. One is the oncogenicity induced by the HER-2 proto-oncogene which is overexpressed in about one fourth of human breast cancers. AP-2 transcription factors bind to the HER-2 gene promoter and activate its expression. In a striking concurrence, anomalous abundance of AP-2alpha protein or its homolog AP-2gamma is also detected with HER-2 in mammary tumor-derived cell lines. This indicates that deregulation of AP-2 is the preceding pathogenic event and probably the pivotal one in this type of mammary carcinogenesis. My laboratory examined the process of AP-2 gene expression in mammary carcinoma cell lines to pinpoint where the aberration had occurred. We excluded a number of possibilities such as increased gene copy number, gene transcription, and mRNA stability. We find that AP-2 proteins have extended stability in breast cancer cell lines. Further investigation reveals that the breast cancer cells are defective in the ubiquitin-dependent proteasomal-degradation pathway which results in the accumulation of AP-2 proteins. Our studies confirm that this defect is the prime reason that eventually causes overexpression of HER-2 gene and culminates in breast cancer. In this ongoing research, we are tracking the disease further backwards to identify the nature of the aberration in the proteasomal-degradation pathway, studying the prevalence in breast cancer patients and developing prognostic markers and strategies for pharmacological intervention. The second one is the ras-oncogene signal transduction pathway in teratocarcinoma. Intriguingly, AP-2 causes sequestration of coactivators when it is aberrantly overexpressed in ras-transformed cells. Our investigation reveals that many accessory proteins are necessary for the normal functioning of transcription factor AP-2 which it shares with other activators. The balance of cellular transcriptional activity is affected when the levels of AP-2 proteins are anomalously high. We identified two coactivators: positive coactivator-4 and poly(ADP-ribose) polymerase-1. Our studies show that both have tumor suppressor property.

Selected Publications
Li, M., Naidu, P., Yu, Y., Berger, N. A., and Kannan, P. 2004. Dual regulation of AP-2a transcriptional activation by poly(ADP-Ribose) polymerase-1. Biochem. J. 382:323-329 Go to Publication

Li, M., Wang, Y., Yu, Y., Li, M., Nishizawa, M., Nakajima, T., Ito, S., and Kannan, P. 2002. The human transcription factor AP 2gamma: gene structure, promoter, and expression in mammary carcinoma cell lines. Gene 302:43-51 Go to Publication

Wankhade S, Yu Y, Weinberg J, Tainsky MA, Kannan P. 2000. Characterization of the activation domains of AP-2 family transcription factors. J Biol Chem. 275:29701-29708. Go to Publication

Kannan P, Yu Y, Wankhade S, Tainsky MA. 1999. PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation. Nucleic Acids Res. 27:866-874. Go to Publication

Kannan P, Tainsky MA. 1999. Coactivator PC4 mediates AP-2 transcriptional activity and suppresses ras-induced transformation dependent on AP-2 transcriptional interference. Mol Cell Biol. 19:899-908. Go to Publication

Irene L. Katzan, M.D., M.S.
Assistant Professor of Neurology
Senior Researcher
Center for Health Care Research and Policy
Director, Strokes Outcomes Research Program
TEL: (216) 778-7498
FAX: (216) 778-3945

Biosketch

Research Interest(s)
Outcomes of Stroke and other Neurologic Diseases. Special areas of interest include: effectiveness of stroke therapies in community setting, effect of medical complications on outcomes after stroke, healthcare utilization for stroke.

Selected Publications
Katzan IL, Cebul RD, Husak SH, Dawson NV, Baker DW. The Effect of Pneumonia on Mortality Among Patients Hospitalized for Acute Stroke. Neurology 2003;60:620-625.

Katzan IL, Graber TM, Furlan AJ, Sundararajan S, Sila CA, Houser G, Landis DM Cuyahoga County Operation Stroke: Speed of Emergency Department Evaluation and Compliance with NINDS Time Targets. Stroke 2003;34:994-998.

Katzan IL, Hammer MD, Furlan AJ, Hixson ED, Nadzam DM. Quality Improvement and Tissue-Type Plasminogen Activator for Acute Ischemic Stroke: A Cleveland Update. Stroke 2003;34:799-800.

Katzan IL, Hammer MD, Furlan AJ, Hixson ED, Abou-Chebl A, Nadzam DM. Utilization of Intravenous Tissue Plasminogen Activator for Acute Ischemic Stroke. Arch Neurol 2004;61:346-350.

Elizabeth Kaufman, M.D.
Assistant Professor of Medicine
Cardiac Electrophysiologist
TEL: (216) 778-2249
FAX: (216) 778-3927

Curriculum Vitae

Research Interest(s)
Long QT syndrome, T wave alternans, cardiac arrhythmias, autonomic control of the heart, prevention of sudden cardiac death.

Selected Publications
Kaufman ES, Priori SG, Napolitano C, Schwartz PJ, Iyengar S, Elston RC, Schnell AH, Gorodeski EZ, Rammohan G, Bahhur NO, Connuck D, Verrilli L, Rosenbaum DS, Brown AM. Electrocardiographic prediction of abnormal genotype in congenital long QT syndrome: experience in 101 related family members. J Cardiovasc Electrophysiol 2001;12:455-461

Kaufman ES, Mackall JA, Julka B, Drabek C, Rosenbaum DS. Influence of heart rate and sympathetic stimulation on arrhythmogenic T-wave alternans. Am J Physiol Heart Circ Physiol 2000;279(3):H1248-H1255.

Moss AJ, Zareba W, Kaufman ES, Gartman E, Peterson DR, Benhorin J, Towbin JA, Keating MT, Priori SG, Schwartz PJ, Vincent GM, Robinson JL, Andrews ML, Feng C, Hall WJ, Medina A, Zhang L, Wang Z. Increased risk of arrhythmic events in long QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel. Circulation 2002;105:794-799.

Michael W. Keith, M.D.
Director, Division of Hand Surgery
Department of Orthopaedics
MetroHealth Medical Center
Professor of Orthopaedics and BioMedical Engineering
Case Western Reserve University
TEL: (216) 778-4399
FAX: (216) 778-4690



Research Interest(s)
Spinal Cord Injury

Kevin Kilgore, Ph.D.
Staff Scientist, Dept. of Orthopaedics
MetroHealth Medical Center
Case Western Reserve University
TEL: (216) 778-3801


Web Page

Research Interest(s)
Functional Electrical Stimulation, with a focus on providing hand function for individuals with spinal cord injury.

Selected Publications
Kilgore KL, Peckham PH, Keith MW, Montague FW, Hart RL, Gazdik MM, Bryden AM, Snyder SA, Stage TG. The durability of implanted electrodes and leads in upper extremity neuroprostheses. J. Rehab Research and Development 40(6):457-468, 2003.

Peckham PH, Keith MW, Kilgore KL, Grill JH, Wuolle KS, Thrope GB, Gorman P, Hobby J, Mulcahey MJ, Carroll S, Hentz V, Wiegner A., Efficacy of an Implanted Neuroprosthesis for Restoring Hand Grasp in Tetraplegia: A Multicenter Study, Arch. Physical Medicine and Rehabilitation, 82:1380-8, 2001.

Kilgore KL, Scherer M, Bobblitt R, Dettloff J, Dombrowski DM, Godbold N, Jatich JW, Morris R, Penko JS, Schremp ES, Cash LA, Neuroprosthesis consumers` forum: consumer priorities for research directions, J Rehabilitation Research and Development, 38:655-660, 2001

John P. Kirwan, Ph.D., FACSM
Associate Professor of Reproductive Biology, Nutrition, Physiology & Biophysics
Department of Nutrition
Case Western Reserve University at
MetroHealth Medical Center
TEL: (216) 778-8848
FAX: (216) 778-7101


Web Page for Profile

Research Interest(s)
Dr. Kirwan’s research expertise is in bench and human clinical investigation regarding nutrient metabolism, insulin action, body composition, and physical activity. He is currently performing research on the effects of age, exercise, and diet on insulin resistance and obesity in the elderly. Additional areas of focus are: to evaluate maternal metabolic, hormonal, genetic, and environmental determinants of fetal growth and body composition and to examine the mechanism(s) underlying improved insulin sensitivity in human skeletal muscle after exercise-training.

Selected Publications
KIRWAN, J.P., M. Jing, A. Varashtapoor, J. Shao, J.E. Friedman, and P.M. Catalano. Reversal of insulin resistance postpartum is linked to enhanced skeletal muscle insulin signaling. J. Clin. Endocrinol. Metab. (In Press), 2004.

KIRWAN, J.P. and L.F. del Aguila. Insulin signaling, exercise and cellular integrity. Biochem. Soc. Trans. 31: 1281-1285, 2003.

Krishnan RK, Evans WJ, KIRWAN JP. Glucose clearance is delayed after hyperglycemia in healthy elderly men. J Nut. 133: 2363-2366, 2003.

Krishnan, R.K., W.J. Evans, and J.P. KIRWAN. Impaired substrate oxidation in healthy elderly men after eccentric exercise. J. Appl. Physiol. 94: 716-723, 2003.

Catalano, P.M., J.P. KIRWAN, S. Hauguel-de Mouzon, and J. King. Gestational diabetes and insulin resistance: Role in short and long term implications for mother and fetus. J. Nutr. 133: 1674S-1683S, 2003.

Diana Kunze, Ph.D.
Professor of Neurosciences
Senior Staff Scientist Rammelkamp
TEL: (216) 778-8967
FAX: (216) 778-2090

Curriculum Vitae
Web Page

Research Interest(s)
Mechanisms of cardio-respiratory control. Areas of interest include (a) contributions of ion channels to the plasticity of blood pressure and heart rate control (b) role of ion channels in adaptions to intermittent hypoxia as a model for sleep apnea. Techniques include patch clamp electrophysiological analysis of cultured neurons and brain slice preparations, immunohistochemistry, calcium imaging, neuronal modeling, molecular biology including single cell RT-PCR and analysis of knockout mice with ion channel defects.

Selected Publications
Doan T.N.; Kunze, D.L. Contribution of the hyperpolarization-activated current (IH) to the resting membrane potential of neonatal rat nodose sensory neurons, J. Physiol. 514:125-138 1999

Balkowiec, A,. Kunze, D.L.; Katz, D Brain-derived neurotrophic factor acutely inhibits AMPA-mediated currents in developing sensory relay neurons. J Neurosci. 20:1904-11. 2000

Andrews, E. M., Kunze,D.L. Voltage-gated potassium channels in chemoreceptor sensory neurons of rat petrosal ganglion Br Research, 897:199-203 2001

Yuri Kuryshev, Ph.D.
Staff Scientist
TEL: (216) 778-8976
FAX: (216) 778-8282



Research Interest(s)
Iron-overloading and cardiac current abnormalities. Iron-induced myocardial disease is the most frequent cause of death in talassemia major and is a major life-limiting complication of transfusion-dependent refractory anemias hereditary hemochromatosis and other forms of iron overload. Our studies performed on isolated cardiomyocytes have identified iron-induced abnormalities both in overall cardiac action potential (CAP) and in specific membrane currents. In particular, we showed that iron-loaded cardiomyocytes had decreased overshoot and duration of the CAP, the Na+ current was deacreased, but K+ transient outward current was increased. The goals of our current research are to: 1) characterize the molecular basis of iron-induced abnormalities of ion currents in cardiac myocytes in culture and in a new animal model of the cardiomyopathy of iron overload, Mongolian gerbils, and 2) to determine the potential role of this abnormalities in pathophysiology of iron-overloaded heart.

Selected Publications
Kuryshev Ya, Wible BA, Gudz TI, Ramirez AN, Brown AM. KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression. Am J Physiol Cell Physiol. 2001 Jul;281(1):C290-9.

Mattera R, Stone GP, Bahhur N, Kuryshev YA. Increased release of arachidonic acid and eicosanoids in iron-overloaded cardiomyocytes. Circulation. 2001 May 15;103(19):2395-401.

Kuryshev YA, Brown AM, Wang L, Benedict CR, Rampe D. Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels. J Pharmacol Exp Ther. 2000 Nov;295(2):614-20.

Irving Kushner, M.D.
Professor of Medicine
Case Western Reserve University at
MetroHealth Medical Center
TEL: (216) 778-5988, (216) 778-4765
FAX: (216) 778-2770

Curriculum Vitae

Research Interest(s)
Dr. Kushner is studying the molecular mechanisms by which inflammation causes the liver to increase production of an important plasma protein, C-reactive protein (CRP). Two messenger molecules, produced at the site of inflammation, bind to receptors on the surface of liver cells, with consequent activation of several families of proteins (called transcription factors). They move to the nucleus and cause increased CRP transaction. The lab is defining the interactions between the transcription factors and the CRP gene.

Selected Publications
Agrawal A, Samols D, Kushner I. Transcription factor c-Rel enhances C-reactive protein expression by facilitating the binding of C/EBPbeta to the promoter. Mol Immunol. 2003 Oct;40(6):373-80

Agrawal A, Cha-Molstad H, Samols D, Kushner I. Overexpressed nuclear factor-kappaB can participate in endogenous C-reactive protein induction, and enhances the effects of C/EBPbeta and signal transducer and activator of transcription-3. Immunology. 2003 Apr;108(4):539-47

Agrawal A, Cha-Molstad H, Samols D, Kushner I. Transactivation of C-reactive protein by IL-6 requires synergistic interaction of CCAAT/enhancer binding protein beta (C/EBP beta) and Rel p50. J Immunol. 2001 Feb 15;166(4):2378-84. PMID: 11160296 [PubMed - indexed for MEDLINE]

Pincus T, Ferraccioli G, Sokka T, Larsen A, Rau R, Kushner I, Wolfe F. Evidence from clinical trials and long-term observational studies that disease-modifying anti-rheumatic drugs slow radiographic progression in rheumatoid arthritis: updating a 1983 review. Rheumatology (Oxford). 2002 Dec;41(12):1346-56

Kushner I, Sehgal AR. Is high-sensitivity C-reactive protein an effective screening test for cardiovascular risk? Arch Intern Med. 2002 Apr 22;162(8):867-9

Karen Kutoloski, D.O.
Director, Cardiac Rehabilitation
Assistant Professor
Case Western Reserve University
TEL: (216) 778-2431


Research Interest(s)
Preventative Cardiology, Cardiac imaging, Outcomes research, Clinical Trials

Kenneth Laurita, Ph.D.
Assistant Professor of Medicine and Biomedical Engineering
Senior Scientist
TEL: (216) 778-7340
FAX: (216) 778-1261

Curriculum Vitae

Research Interest(s)
Cellular mechanisms of cardiac arrhythmias using fluorescent imaging of transmembrane potential and intracellular calcium in the intact heart. Cardiac repolarization and its influence on arrhythmia vulnerability. Intracellular calcium homeostasis and its role in arrhythmogenesis. Mechanisms of cardiac impulse propagation and block. Instrumentation and software design for imaging the electrical activity of the heart.

Selected Publications
Laurita KR, Singal A. Mapping action potentials and calcium transients simultaneously from the intact heart. American Journal of Physiology. 2001;280:H2053-H2060.

Laurita KR, Rosenbaum DS. The interdependence of modulated dispersion and tissue structure in the mechanism of unidirectional block. Circulation Research. 2000;87:922-928.

Laurita KR, Girouard SD, Akar FG, Rosenbaum, DS. Modulated dispersion explains changes in arrhythmia vulnerability during premature stimulation of the heart. Circulation. 1998;98:2774-2780.

Michael M. Lederman, M.D.
Scott R. Inkley Professor of Medicine
Professor of Biomedical Ethics, Pathology, Microbiology and Molecular Biology
Director, Center for AIDS Research
Case Western Reserve University
TEL: (216) 844-8786
FAX: (216) 844-5523


Research Interest(s)
Identifying mechanisms of immune deficiency and host defenses in HIV disease, and in exploring methods to enhance them.

Selected Publications
Sieg, S.F., Bazdar, D.A., Lederman, M.D. Impaired T cell receptor-mediated induction of Ki67 by naïve CD4+ T cells is only occasionally corrected by exogenous interleukin-2 in HIV-1 infection. J. Immunology 171:5208-14, 2003.

Salkowitz, J.R., Sieg, S.F., Harding, C.V., Lederman, M.M. In vitro human memory CD8 T cell expansion in response to cytomegalovirus requires CD4+ T cell help. J. Inf. Dis. 204:971-83, 2004.

Martin, M.P., Lederman, M.M., Hutcheson, H., Nelson, G.W., Goedert, J.J., Detels, R., Buchbinder, S., Hoots, K., Vlahov, D., Obrien, D.J., Carrington, M., Association of DC-SIGN promoter polymorphisms with increased risk for parenteral but not mucosal acquisition of HIV-1 infection. J. Virol. 78:14053-56, 2004.

Lederman, M.M., Veazey, R., Hartley, O., Mosier, D., Dufour, J., Mefford, M., Piatak, M., Jr., Salkowitz, J.R., Rodriguez, B., Blauvelt, A., Offord, R. Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5. Science 306:485-7, 2004.

William Lewis, M.D.
Assistant Professor of Medicine
Director, Clinical Electrophysiology Section
TEL: (216) 778-2249
FAX: (216) 778-3927


Research Interest(s)
Cardiac Repolarization, Cardiac Arrhythmias, Cardiac Autonomic Control.

Selected Publications
Lewis, W., Carlson, M. Systolic Blood Pressure at Rest, Not the Degree of Beta Blockade, Predicts the Result of Follow-Up Tilt Table Testing for Vasovagal Syncope. Am J Cardiol 80:351-353, 1997.

Harrington MD, Luebke DL, Lewis WR, Auliso MP, Johnson NJ. Fast Facts and Concepts #112. IMPLANTABLE CARDIOVERTER DEFIBRILLATOR (ICD) AT END OF LIFE. April 2004. End-of-Life Physician Education Resource Center www.eperc.mcw.edu Go to Publication

Harrington MD, Luebke DL, Lewis WR, Auliso MP, Johnson NJ. Fast Facts and Concepts #111. Cardiac Pacemakers at End-of-life. April 2004. End-of-Life Physician Education Resource Center www.eperc.mcw.edu Go to Publication

Lewis W and Kaufman E. ECG monitoring. In Webb A, Shapiro M, Singer M and Suter P (Eds) Oxford Textbook of Critical Care, Oxford University Press, Oxford, New York, Tokyo, 1999, pp1083-1085

Lewis W. Protrusion of an Active Fixation Pacing Lead into the Abdominal Cavity. J Cardiovas Electrophysiology 11:944, 2000.

Thomas E. Love, Ph.D.
Assistant Professor of Medicine, CWRU School of Medicine
Assistant Professor of Operations, Weatherhead School of Management
Director, Biostatistics and Evaluation Unit,
Center for Health Care Research and Policy
TEL: (216) 778-1265
FAX: (216) 778-3945

Biosketch
Curriculum Vitae
Web Site for Dr. Love

Research Interest(s)
Statistics, Observational Studies, Quality Improvement, Psychometrics, Statistics Education

Selected Publications
Ahmed A Rich MW Love TE Lloyd Jones DM Aban IB Colucci WS Adams KF Gheorghiade M (2006) Digoxin and reduction in mortality and hospitalization in heart failure: A comprehensive post hoc analysis of the DIG trial. European Heart Journal 27: 178-186. With accompanying Editorial by Brophy JM Rehabilitating digoxin.

Bailit JL Love TE Dawson NV (2006) Quality of obstetric care and risk-adjusted primary cesarean rates The American Journal of Obstetrics & Gynecology 194 (2): 402-407.

Litaker D Love TE (2005) Health care resource allocation and individuals` health care needs: Examining the degree of fit. Health Policy 73: 183-193.

Murray PK Love TE Dawson NV Thomas CL Cebul RD (2005) Rehabilitation services following the implementation of the nursing home prospective payment system: Differences related to patient and nursing home characteristics. Medical Care 43: 1109-15.

Love TE Hildebrand DK (2002) Statistics education and the Making Statistics More Effective in Schools and Business (MSMESB) conferences. The American Statistician 56: 107-112.

Rhoderick Machekano, Ph.D., M.P.H.
Assistant Professor of Medicine
Center for Health Care Research and Policy
Center for AIDS Research
Case Western Reserve University
TEL: (216) 778-1952
FAX: (216) 778-3945

Biosketch
Curriculum Vitae

Selected Publications
Machekano R, McFarland W, Hudes E, Bassett M, Mbizvo M, Katzenstein D. Correlates of HIV Test Results Seeking and Utilization of Partner Counseling Services in a Cohort of Male Factory Workers in Zimbabwe. AIDS and Behavior, Vol 4, No. 1, 2000.

Machekano RN, Bassett MT, Zhou PS, Mbizvo MT, Latif AS, Katzenstein DA. Report of Sexually Transmitted Infections by HIV infected men during follow-up: Time to target the HIV infected?. Sex Transm Inf 2000; 76(3) 188-192.

Kassaye SG, Ndayishimiye F, Binswanger H, Sall AY, Machekano R, Israelski DM. Association-driven care and treatment: a model for community-based delivery of HIV/AIDS healthcare in resource-limited settings. AIDS. 2006 Jul 13;20 (11):1561-2.

Damon Francis, Samuel L. Nsobya, Ambrose Talisuna, Adoke Yeka, Moses R. Kamya, Rhoderick Machekano, Christian Dokomajilar, Philip J. Rosenthal, Grant Dorsey. Geographic Differences in Antimalarial Drug Efficacy in Uganda are Explained by Differences in Endemicity not Known Molecular Markers of Drug Resistance. J Infect Dis. 2006 Apr 1;193 (7):978-86.

Mark Malangoni, M.D.
Chairperson, Department of Surgery
Surgeon-in-Chief
MetroHealth Medical Center
Professor of Surgery
Case Western Reserve University
TEL: (216) 778-4558
FAX: (216) 778-1099

Curriculum Vitae

Selected Publications
Delayed operative intervention in the management of traumatic descending thoracic aortic rupture.Ann Thorac Surg. 2002 Nov;74(5):S1888-91; discussion S1892-8. Go to Publication

Admitting service influences the outcomes of patients with small bowel obstruction.Surgery. 2001 Oct;130(4):706-11; discussion 711-3 Go to Publication

Geriatric trauma hospitalization in the United States: a population-based study.J Clin Epidemiol. 2001 Jun;54(6):627-33 Go to Publication

Sanford Markowitz, M.D., Ph.D.
Markowitz-Ingalls Professor of Cancer Genetics
Investigator, Howard Hughes Medical Institute
Howard Hughes Medical Institute Laboratories
Case Western Reserve University
TEL: (216) 368-1976
FAX: (216) 368-8928


Research Interest(s)
My laboratory studies the genetics of human colon cancer. Among our achievements was the discovery that TGF-beta receptors are colon cancer tumor suppressor genes that are mutated in human colon cancers, the discovery that methylation of the hMLH1 repair gene promoter is the pathogenetic event that induces sporadic colon cancers that have microsatellite instability, and the finding that methylation of the E-Cadherin gene is the obligate "second hit" leading to gastric cancers in families with the hereditary diffuse gastric cancer syndrome. Recent discoveries include finding evidence for a novel familial colon cancer gene on chromosome 9q, and discovering a "celebrex like" anti-cancer activit of the TGF-beta pathway. Current research interests in the laboratory include finding the actual new familial colon cancer gene on chromsome 9q, developing new molecular diagnostic tests for early detection of colon cancer, and elucidating genes that play a role in metastatic colon cancers.

Selected Publications
Recent citations from the laboratory are:Yan M, Rerko R, Platzer P, Dawson D, Willis J, Tong M, et al. 15-Hydroxyprostaglandin Dehydrogenase, a COX-2 oncogene antagonist, is a TGF-ß induced suppressor of human gastrointestinal cancers. Proc Natl Acad Sci U S A 2004;101:17468-17473. (selected for a cover citation)

Wiesner G, Daley D, Lewis S, Ticknor C, Platzer P, Lutterbaugh J, et al. A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2. Proc Natl Acad Sci U S A 2003;100:12961-12965.

Li H, Myeroff L, Smiraglia D, Romero MF, Pretlow TP, Lakshmi Kasturi L, et al. SLC5A8: A novel sodium transporter, is a tumor suppressor gene silenced by methylation in human colonic aberrant crypt foci and colon cancers. Proc Natl Acad Sci U S A 2003;100:8412-17.

Arthur J. McCullough, M.D.
Director, Gastroenterology Division
MetroHealth Medical Center
Professor, Department of Gastroenterology
Case Western Reserve University
TEL: (216) 778-5736
FAX: (216) 778-4873

Curriculum Vitae

Research Interest(s)
Dr. McCullough has two primary areas of research interests. The first is to study the normal response of protein and energy metabolism during feeding and how the presence of cirrhosis will affect that response. The second is to further delineate the causes of abnormal energy and protein metabolism in cirrhosis, while evaluating new nutritional and pharmacologic strategies in vivo to correct these abnormalities.

Selected Publications
McCullough AJ. Update on nonalcoholic Fatty liver disease. J Clin Gastroenterol. 2002 Mar;34(3):255-62

Falck-Ytter Y, Kale H, Mullen KD, Sarbah SA, Sorescu L, McCullough AJ. Suprisingly small effect on antiviral treatment in patients with hepatitis C. Ann Intern Med. 2002 Feb 19;136(4):288-292.

Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, McCullough AJ, Natale S, Forlani G, Melchionda N. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001 Aug;50(8):1844-1850.

McCullough AJ, Raguso C. Effect of cirrhosis on energy expenditure. Am J Clin Nutr (In Press).

Matteoni CA, Younossi ZM, Gramlich T, Liu YC, Bopari N, McCullough AJ. Non-alcoholic fatty liver disease: Risk factors and long-term outcomes. Gastroenterology (In Press).

E. Regis McFadden Jr., M.D.
Argyl J. Beams Professor of Medicine
MetroHealth Medical Center
Professor
Case Western Reserve University
TEL: (216) 778-4848



Research Interest(s)
Pulmonary Medicine / Asthma Airway Diseases

Christopher McHenry, M.D.
Professor of Surgery
Vice Chairman Department of Surgery Metrohealth Medical Center
Director, Division of General Surgery MetroHealth Medical Center
TEL: (216) 778-4753
FAX: (216) 778-3774


Research Interest(s)
Nodular thyroid disease, thyroid cancer,hyperparathyroidism, functioning and nonfunctioning tumors of the adrenal gland, islet cell tumors of the pancreas and surgical infections

Selected Publications
Mittendorf EA, McHenry CR. Thyroid Cancer. In: Current Surgical Therapy, Eight Edition, Cameron JL (ed), Elsevier Science, Philadelphia,PA;2004:584-591.

Mittendorf E, Merlino J., McHenry CR. Post-parathyroidectomy hypocalcemia: incidence, risk factors and management. Am Surg 70(2):114-120, 2004.

Merlino JL, Ko K, Minotti A, McHenry CR. The false negative technetium-99m-sestamibi scan in patients with primary hyperparathyroidism: correlation with clinical factors and operative findings. Am Surg 69(3):225-230, 2003.

Mittendorf EA, Tamarkin S, McHenry CR. The results of ultrasound-guided fine needle aspiration biopsy for evaluation of nodular thyroid disease. Surgery 132:648-654, 2002.

McHenry CR. Patient volumes and complications in thyroid surgery. Br J Surg 89:821-823, 2002.

Elizabeth D. McKinley, M.D., M.P.H.
Academic Society Dean, Case School of Medicine
Assistant Professor of Medicine, Biomedical Ethics
and Epidemiology and Biostatistics
Staff Physician, Department of Medicine
TEL: (216) 368-0324 (Case)

Biosketch
Curriculum Vitae

Research Interest(s)
Improving the process and outcomes of breast cancer care, uncertainty in breast cancer, breast cancer survivorship.

Selected Publications
McKinley ED, Thompson JW, Briefer-French J. Performance Indicators in Women’s Health: Incorporating Women’s Health in the Health Plan Employer Data and Information Set (HEDIS). Women’s Health Issues, 11/01.ley ED, Thompson JT, Briefer-Frien.

Tierney WM, McKinley ED. When the Researcher Gets Cancer: Understanding Cancer, Its Treatment, and Quality of Life from the Patient’s Perspective. Medical Care, In Press.

McKinley ED, Headrick LA, Stange KC. Using Process Diagrams with Patients to Improve Breast Cancer Care. Under review, The Joint Commission Journal on Quality Improvement, 10/01.

Brian M. Mercer, M.D.
Professor of Reproductive Biology
Vice-chair, Ob/Gyn, MetroHealth Medical Center
Director of Maternal-Fetal Medicine
TEL: (216) 778-8446
FAX: (216) 778-8847


Curriculum Vitae

Research Interest(s)
Dr. Mercer conducts research related to clinical complications of pregnancy, with a focus on prematurity. He has extensive experience in the conduct and analysis of clinical studies and randomized trials related to prediction and prevention of preterm birth as well as prevention of infant morbidity and mortality related to prematurity. These studies involve women with prior obstetric complications and also those at risk for preterm birth in the current pregnancy.

Selected Publications
As-Sanie S, MERCER B, Moore J. Is RDS near term a marker for other neonatal morbidities? Am J Obstet Gynecol 189:1053-1057, 2003.

Meis PJ, Klebanoff M, Thom E, Dombrowski MP, Sibai B, Moawad AH, Spong CY, Hauth JC, Miodovnik M, Varner MW, Leveno KJ, Caritis SN, Iams JD, Wapner RJ, Conway D, O`Sullivan MJ, Carpenter M, MERCER B, Ramin SM, Thorp JM, Peaceman AM. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med 348:2379-2385, 2003.

MERCER BM. Premature Rupture of the membranes. An expert’s view. Obstet Gynecol 101: 178-193, 2003.

Herbst M, MERCER B, Beazley D, Meyer N, Carr T. Relationship of Prenatal Care and Perinatal Morbidity in Low Birth Weight Infants. Am J Obstet Gynecol 2003;189:930-3.

Moawad AH, Goldenberg RL, MERCER B, Meis PJ, Iams JD, Das A, Caritis SN, Miodovnik M, Menard MK, Thurnau GR, Dombrowski M, Roberts JM. The Preterm Prediction Study: the value of serum alkaline phosphatase, alpha-fetoprotein, plasma corticotropin-releasing hormone, and other serum markers for the prediction of spontaneous preterm birth. Am J Obstet Gynecol. 2002;186(5):990-6.

R. Tyler Miller, M.D.
Professor of Medicine and Physiology
Department of Physiology and Biophysics
Case Western Reserve University
TEL: (216) 791-3800 x5180
FAX: (216) 231-3470

Biosketch

Research Interest(s)
My laboratory studies two areas, G protein signaling and responses of epithelial cells to mechanical force. In the area of G protein signaling, we focus on the calcium-sensing receptor (CaR), a receptor that is expressed in the parathyroid where it controls PTH secretion, in the kidney where it contributes to regulation of Na, K, Cl, Ca, Mg, and H2O balance, and in many other epithelial tissues where its function is not well defined. Our current studies are designed to define the molecular mechanisms that determine the signaling specificity for this receptor by identifying interacting and scaffolding proteins. We are currently working with the inwardly-rectifying K channel family, Kir4.x along with the lipid signaling pathways that regulate it, and filamin, a cytoskeletal protein that also acts as a scaffold. These two proteins appear to be responsible for some of the unique biologic effects of the CaR. The Kir4.x channels may be responsible for the profound effects of the CaR on fluid and electrolyte balance. We are preparing to study the role of this receptor in regulating salt and water balance in humans in a GCRC setting. Filamin appears to be responsible for CaR trafficking and the organization of additional proteins in its neighborhood. These issues are being addressed in cultured cell and genetic systems. We are also studying the effects of mechanical force on glomerular podocytes, cells that are exposed increased mechanical force due to increased glomerular pressure and flow following renal injury. In this work, we are evaluating the responses of cells to growth on substrates with a range of mechanical properties reflecting exposure of the cells to different levels of tension. We are measuring cell structure (cytoskeleton focusing on filamin, the most important protein for determination of cytoskeletal strength and rigidity) growth, migration, and metabolic function including production of second messengers and oxygen radicals. This work is designed to address the reasons why glomerular injury is a progressive process.

Selected Publications
Awata H, Huang C, Handlogten M.E., Miller R.T. Interaction of the Calcium-sensing Receptor and Filamin, a Potential Scaffolding Protein. J Biol Chem 276 (37): 34871-9, 2001.

Huang C, Handlogten ME, Miller RT. Parallel Activation of Phosphatidylinositol 4-Kinase and Phospholipase C by the Extracellular Calcium-sensing Receptor. J Biol Chem. 277 (23):20293-300, 2002.

Huang C, Hujer K, Zhenzhen W, Miller RT. Am J Physiol cell Physiol 286: C22-C30, 2004.

John J. Moore, M.D.
Professor of Pediatrics and Reproductive Biology
Case Western Reserve University
Director, Neonatal Intensive Care Unit
MetroHealth Medical Center
Program Director, CWRU-CCF-MetroHealth Neonatology Fellowhship Training Program
TEL: (216) 778-5909, (216) 778-5946
FAX: (216) 778-3252


MetroHealth Neonatology

Research Interest(s)
The general area of my research interest is the determination of the control system for the onset of human parturition. This problem in physiology has direct clinical importance because premature and dysfunctional labors result in significant neonatal mortality and morbidity. Our research focus has been upon the control of the elaboration of prostaglandins from tissues of the fetal membranes (amnion, chorion and decidua), and the effects of these agents upon uterine contraction, and more recently, upon rupture of the membranes. Primary cultures of cells from human fetal membranes, human explant cultures, amnion derived WISH cells, and occasionally pregnant animals are used as model systems. Receptor and post receptor signaling cascades which cause increased prostaglandin release, or increased mRNA or protein production of the rate controlling steps in prostaglandin production (cyclooxygenase) are under study. Recently we have explored a possible relationship between cellular and membrane stretch and increased transcription of cyclooxygenase and other labor related genes in amnion; and the role of prostaglandins in remodeling and apoptosis of the amnion.

Most recently we have turned our focus toward determining the mechanism of the developmental process of weakening, leading to rupture of the fetal membranes. This weakening appears to be a tissue remodeling process involving apoptosis and activation of matrix metalloproteinases. We have developed technology to measure the physical strength properties of fetal membranes (in vitro) and to correlate these with biochemical and histological characteristics. This has allowed us to determine, for the first time, that a zone of weakness with unique biochemical and histological characteristics develops in the membrane region overlying the cervix in late gestation. We are exploring the gestational timing of this event, its physiological control, and the potential to therapeutically reverse this process. Our hope is to be able to provide some therapeutic help for the 40% of preterm births in which the initiating event is preterm rupture of the fetal membranes

Selected Publications
Lundgren DW, Moore RM, Collins PL, Moore JJ. Hypotonic stress increases cyclooxygenase release form amnion-derived WISH cells. J Biol Chem 272:20118-20124 1997.

Kumar D, Greer FR, Super DM, Suttie JW, Moore JJ. Vitamin K status of premature infants. Pediatrics 108:1117-22, 2001.

Moore RM, Lundgren DW, Silver RJ, Moore JJ. Ceramide lactoside induced apoptosis in primary amnion cells and amnion derived WISH cells. J Soc Gyn Inv 9:282-9, 2002.

Kumar D, Moore RM, El-Khwad M, Silver RJ, Moore JJ. Vitamin C exacerbates the effect of hydrogen peroxide induced apoptosis and concomittent PGE2 release in amnion epithelial and mesenchymal cells and intact amnion. Placenta 25:573-579, 2004.

Kumar D, Moore RM, Silver RJ, Moore JJ, Lundgren DW. Hydrogen peroxide induced apoptosis in amnion-derived WISH cells is not inhibited by vitamin C. Placenta 25:266-272, 2004

Kevin Mullen, M.D.
Physician, Gastroenterology
MetroHealth Medical Center
Professor
Case Western Reserve University
TEL: (216) 778-5736


Research Interest(s)
Hepatic encephalopathy, intermediary metabolism in liver disease, nutritional support in liver disease and viral hepatitis.

Patrick K. Murray, M.D., M.S.
Associate Professor, Division of General Medical Sciences
Center for Physical Medicine and Rehabilitation
Dept. of Physical Medicine and Rehabilitation
TEL: (216) 778-8529
FAX: (216) 778-3945

Biosketch
Curriculum Vitae

Research Interest(s)
Outcomes of rehabilitation services in nursing homes; improving quality of life in long term care.

Selected Publications
Murray PK, Singer ME, Dawson NV, Thomas CL, Cebul RD: Outcomes of Rehabilitation Services in Nursing Home Residents, Arch Phys Med Rehabil. 84: 1129-36 (2003)

Murray PK, Dawson NV, Thomas CL, Cebul RD: Are We Selecting the Right Patients for Stroke Rehabilitation in Nursing Homes. Arch Phys Med Rehabil.; May;86:876-880 (2005)

Wilson RD, Murray PK. Cost-Effectiveness of Screening for Deep Vein Thrombosis by Ultrasound at Admission to Stroke Rehabilitation. Arch Phys Med Rehabil 86: 1941-1948 (2005)

Murray PK, Love TE, Dawson NV, Thomas CL, Cebul RD. Rehabilitation services following the implementation of the nursing home prospective payment system: Differences related to patient and nursing home characteristics. Medical Care 43:1109-1115 (2005)

Del Rio RA, Goldman M, Kapella BK, Sulit L, Murray PK. The accuracy of minimum data set diagnoses in describing recent hospitalization at acute care facilities. J Am Med Dir Assoc. 2006 May;7(4):212-8.

Duncan vB. Neuhauser, Ph.D.
The Charles Elton Blanchard, M.D.
Professor of Health Management and
Professor of Epidemiology and Biostatistics
School of Medicine
Case Western Reserve University
TEL: (216) 368-3725
FAX: (216) 368-3970

Curriculum Vitae

Timothy O`Brien, M.D.
Physician, Hematology & Oncology
MetroHealth Medical Center
Asssistant Professor
Case Western Reserve University
TEL: (216) 778-5802

Elizabeth O`Toole, M.D.
Associate Professor of Medicine, Bioethics, and Family Medicine
Case Western Reserve University,
Director, Section of Geriatrics and Palliative Care
Division of General Internal Medicine
TEL: (216) 778-2777
FAX: (216) 778-5935



Selected Publications
Rose JH, O’Toole EE, Dawson NV, Thomas C, Hamel MB, Cohen HJ (manuscript under review). Care perspectives and patterns of association with outcomes for hospitalized middle-aged and older cancer patients. Am J Med.

Hershkovitz A, Rothschild BM, Rose JH, Hornick T, & O’Toole EE. Medical care perceptions in elderly patients with musculoskeletal complaints. The Israel Medical Association Journal, 2001 Nov; (3):822-27.

Norris R, O’Toole E Whitehouse PJ. Ethical Issues in Special Care Units. Research and Practice in Alzheimer’s Disease, 2000 4:261-271.

Tomoko Obara, Ph.D.
Assistant Professor
Department of Medicine, MetroHealth Medical Center
Case Western Reserve University
TEL: (216) 778-8618

Prabhu S. Parimi, M.D.
Assistant Professor, Department of Pediatrics
MetroHealth Medical Center
Case Western Reserve University
TEL: (216) 778-5909



Research Interest(s)
A). The major focus our studies is to understand the influence of a number of host and nutritional related variables on the metabolism of essential and conditionally essential amino acids in new born infants using stable isotopic tracer methodology.B). Intrauterine growth restriction: mechanisms and its consequences. Our group is studying two models of intrauterine growth restriction: (a) reduced environmental oxygen, and (b) protein restricted diet to the mother during pregnancy. Our preliminary data suggest that changes in redox state influence the expression of key genes involved in the adaptation to extrauterine environment, and that these responses are regulated at the transcription level. On the other hand, protein restriction to the mother causes profound changes in the maternal protein metabolism that lead to restricted delivery of nutrients to the fetus, and ultimately impact the translation of proteins in the liver and skeletal muscle. These studies are being done in rat pregnancy.

Selected Publications
Parimi PS, Cripe-Mamie C, Kalhan SC. Related Articles, Links Metabolic Responses to Protein Restriction During Pregnancy in Rat and Translation Initiation Factors in the Mother and Fetus.Pediatr Res. 2004 Jul 7 [Epub ahead of print] PMID: 15240862 [PubMed - as supplied by publisher]

Parimi PS, Devapatla S, Gruca LL, Amini SB, Hanson RW, Kalhan SC. Effect of enteral glutamine or glycine on whole-body nitrogen kinetics in very-low-birth-weight infants. Am J Clin Nutr. 2004 Mar;79(3):402-9.

Parimi PS, Croniger CM, Leahy P, Hanson RW, Kalhan SC. Effect of reduced maternal inspired oxygen on hepatic glucose metabolism in the rat fetus. Pediatr Res. 2003 Feb;53(2):325-32.

Kalhan SC, Gruca LL, Parimi PS, O`Brien A, Dierker L, Burkett E. Serine metabolism in human pregnancy.Am J Physiol Endocrinol Metab. 2003 Apr;284(4):E733-40. Epub 2002 Dec 17.

Parimi PS, Devapatla S, Gruca L, O’Brien AM, Hanson RW, Kalhan SC: Glutamine and leucine nitrogen kinetics and their relation to urea N in newborn infants. Am J Physiol 282:E618-E625, 2002.

P. Hunter Peckham, Ph.D.
Professor of Biomedical Engineering
Case Western Reserve University
Director of Orthopaedic Research
Member Bioscientific Staff
MetroHealth Medical Center
TEL: (216) 778-3480
FAX: (216) 778-4259


Curriculum Vitae

Research Interest(s)
The major area of Dr. Peckham’s research is in rehabilitation engineering and neuroprostheses. He focuses on functional restoration of the paralyzed upper extremity in individuals with spinal cord injury. He and collaborators have developed implantable neural prostheses that utilize electrical stimulation to control neuromuscular activation, and implemented procedures to provide control of grasp-release in individuals with tetraplegia. This function enables individuals with central nervous system disability to regain the ability to perform essential activities of daily living. His present efforts concern the integration of technological rehabilitation and surgical approaches to restore functional capabilities.

Selected Publications
Peckham PH, Kilgore KL, Keith MW, Bryden AM, Bhadra N, Montague FW. An advanced neuroprosthesis for restoration of hand and upper arm control using an implantable controller. J Hand Surg [Am]. 2002 Mar;27(2):265-276.

Grill WM, McDonald JW, Peckham PH, Heetderks W, Kocsis J, Weinrich M. At the interface: convergence of neural regeneration and neural prostheses for restoration function. J Rehabil Res Dev. 2001 Nov-Dec.;38(6):633-639.

Peckham PH, Keith MW, Kilgore KL, Grill JH, Wuolle KS, Thrope GB, Gorman P, Hobby J, Mulcahey MJ, Carroll S, Hentz VR, Wiegner A. Efficacy of an implanted neuroprosthesis for restoring hand grasp in tetraplegia: a multicenter study. Arch Phys Med Rehabil. 2001 Oct;82(10):1380-1388.

Adam T. Perzynski, M.A., Ph.D.
Senior Instructor
Center for Health Care Research and Policy
Case Western Reserve University at MetroHealth Medical Center
TEL: (216) 778-2850
FAX: (216) 778-3945

Biosketch
Curriculum Vitae

Research Interest(s)
Dr. Perzynski specializes in medical sociology, gerontology and research methods. He is interested in mixed methods research designs that combine diverse approaches from multiple disciplines. Dr. Perzynski also has a passion for social informatics and social theory. His current research includes studies of lay people’s illness knowledge and of the connection between neighborhood disadvantage and health over the life course.

Selected Publications
Stoller, E.P., Webster, N.J., Hund, A., Blixen, C.E., Perzynski, A.T., McCormick, R., Kanuch, S.W., Kercher, K. & Dawson, N.V. (2009). The Applicability of Alcohol Assessment Instruments: A Mixed Methods Study of the Experiences of Nondependent Drinkers Diagnosed with Hepatitis C. Journal of Mixed Methods, vol. 3, no. 1, 65-86.

Blixen, C.E., Webster, N.J., Hund, A.J., Perzynski, A.T., Kanuch, S., Stoller, E.P., McCormick, R. & Dawson, N.V. (2008). Communicating about Alcohol Consumption to Nondependent Drinkers with Hepatitis C: Patient and Provider Perspectives.” Journal of General Internal Medicine, vol. 23, no. 3, 242-247.

Stoller, E.P., Hund, A., Webster, N., Blixen, C., Perzynski, A. McCormick, R., Kanuch, S. and Dawson, N. (2006). “Alcohol Consumption within the Context of Hepatitis C.” Alcohol and Alcoholism, vol. 41, no. 5, pp. 546-552. Available online: http://alcalc.oxfordjournals.org/cgi/content/abstract/41/5/546

Stoller, E.P. & Perzynski, A.T. (2003). "The Impact of Ethnic Involvement and Migration Patterns on Long Term Care Plans among Retired Sunbelt Migrants: Plans for Nursing Home Placement." Journal of Gerontology: Social Sciences, vol. 58B, no. 6, S369-S376.

Longino C.F.J., Perzynski A.T. & Stoller E.P. (2002). “Pandora`s Briefcase: Unpacking the Retirement Migration Decision.” Research on Aging vol. 24, no. 1, pp. 29-49.

Kara Quan, M.D.
Assistant Professor of Medicine
Case Western Reserve University
Director, Cardiovascular and Electrophysiologic Fellowship Programs
Director, Electrophysiologic Laboratory
TEL: (216) 778-7661, (216) 778-2249
FAX: (216)778-3927



Research Interest(s)
Mechanisms of cardiac arrhythmias: areas of special interest include autonomic control, autonomic mechanisms of arrhythmias, influence of electrical alternans on arrhythmogenesis, and the prediction and prevention of sudden cardiac death.

Selected Publications
QUAN KJ, Van Hare GF, Biblo LA, Mackall JA, Carlson MD. Identification and characterization of atrioventricular parasympathetic innervation in humans. J Cardiovascular Electrophysiology, 2002; 13, Number 8: 735-739.

Biblo LA, Yuan Z, Quan KJ, Mackall JA, Rimm AA. The risk of stroke in patients with atrial flutter. Am J Cardiology 87, 346-349, 2001.

Quan KJ, VanHare GF, Biblo LA, Mackall JA, Carlson MD. Human endocardial parasympathetic nerve stimulation: optimal atrial sites and the effect of digoxin. J Interventional Cardiac Electrophysiology 5, 145-152, 2001.

Quan KJ, Lee JH, Geha AS, Biblo LA, VanHare GF, Mackall JA, Carlson MD. Characterizaion of sinoatrial parasympathetic innervation in humans. J Cardiovascular Electrophysiology 10, 1060-1065, 1999.

Kathleen Quealy, M.D.
Cardiologist, Invasive
Assistant Professor
Case Western Reserve University
TEL: (216) 778-5253
FAX: (216) 778-3927


Research Interest(s)
Invasive Cardiology, Critical Care Cardiology, Get with the Guidelines

Louis Rakita, M.D.,C.M.,FACP,FRCPC,FACC
Professor Emeritus of Medicine
Attending Physician, Heart and Vascular Center
MetroHealth Medical Center
TEL: (216) 778-3875, [216} 778-3925
FAX: (216) 778-3927



Research Interest(s)
arrhythmias, ecg

James B. Rebitzer, Ph.D.
Carlton Professor and Chair of Economics Dept.
Weatherhead School of Management
Case Western Reserve University
CHRP Senior Scholar
Research Associate, National Bureau of Economic Research
TEL: (216) 368-5537

Curriculum Vitae
Rebitzer`s Home Page

Research Interest(s)
The economics of organizations and incentive systems, with special emphasison physician incentives; Economics of Labor Markets, with special emphasis on human resource issues in professional and managerial labor markets; Behavioral Economics; Health Economics.

Selected Publications
Gaynor, M., Rebitzer, J and Taylor L. "Incentives in HMOs" Journal of Political Economy, 2004.

Nagan, D., Rebitzer J., Taylor, L., Sanders, S. "Monitoring, Motivation and Management: The Determinants of Opportunistic Behavior in a Field Experiment," The American Economic Review (September 2002)

Landers, R., Rebitzer J., and Taylor, L. "Rat Race Redux: Adverse Selectionin The Determination of Work Hours in Law Firms," The American Economic Review (June 1996).

Mary Jo Roach, Ph.D.
Assistant Professor of Physical Medicine and Rehabilitation
Department of Physical Medicine and Rehabilitation
Case Western Reserve University
Center for Health Care Research and Policy
Spinal Cord Injury Program Manager, Dept. of Physical Medicine and Rehabilitation
MetroHealth Medical Center
TEL: (216) 778-8781
FAX: (216) 778-3945

Biosketch
Curriculum Vitae

Research Interest(s)
Spinal cord injury; community integration; quality of life; medical decision making.

Selected Publications
Roach MJ, Connors AF, Dawson NV, Wenger NS, Wu AW, Tsevat J et al. Depressed mood and survival in seriously ill hospitalized adults. The SUPPORT Investigators. Arch Intern Med 1998; 158(4):397-404.

Krause JS, Kewman D, Devivo MJ, Maynard F, Coker J, Roach MJ et al. Employment after spinal cord injury: an analysis of cases from the Model Spinal Cord Injury Systems. Arch Phys Med Rehabil 1999; 80(11):1492-1500.

Baker R, Wu AW, Teno JM, Kreling B, Damiano AM, Rubin HR et al. Family satisfaction with end-of-life care in seriously ill hospitalized adults. J Am Geriatr Soc 2000; 48(5 Suppl):S61-S69.

M.J. Roach. Community Social Structure as an Indicator of Social Integration and Its Effect on Quality of Life for Persons with a Spinal Cord Injury. Topics in Spinal Cord Injury Rehabilitation. Winter 2002; 7(3); pp. 101-111.

Nicholette Rogers, PhD, PA-C
Physician Assistant
Gastroenterology
MetroHealth Medical Center
TEL: (216) 778-8013
FAX: (216) 778-4873


Research Interest(s)
fatty liver disease, hepatitis c

Peter R. Rose, M.D.
Professor of Reproductive Biology and Oncology
Director of Gynecologic Oncology
TEL: (216) 778-5695
FAX: (216) 778-4741


Curriculum Vitae

Research Interest(s)
Dr. Rose`s clinical activity involves the care of women with Gynecologic Cancer. In an effort to improve patient outcome and provide the most recent and promising treatments Dr. Rose is involved in numerous National Cancer Institute, Gynecologic Oncology Group, and industry sponsored trials.

Selected Publications
ROSE PG. Fallopian tube cancer. In: Textbook of Uncommon Cancer, Second Ed. Raghavan D, Brecher ML, Johnson DH, Meropol NJ, Moots PL, Thigpen JT (eds), John Wiley & Sons, Ltd., Sussex England 1999, pp 689-700.

ROSE PG. Uterine Sarcoma. In: Textbook of Uncommon Cancer, Second Ed. Raghavan D, Brecher ML, Johnson DH, Meropol NJ, Moots PL, Thigpen JT (eds), John Wiley & Sons, Ltd., Sussex, England 1999, pp 689-700.

ROSE PG, Blessing JA, Gershenson DM, McGhee R. Paclitaxel and cisplatin as first line therapy in recurrent or advanced squamous cell carcinoma of the cervix: A Gynecologic Oncology Group study. J Clin Oncol 17:2676-2680, 1999.

Julia H. Rose, Ph.D., M.A.
Professor of Medicine, Geriatrics and Bioethics
Director, Western Reserve Geriatric Education Center
Center for Health Care Research and Policy (CHRP)
Case Western Reserve University
MetroHealth Medical Center
TEL: (216) 368-5433 (VA), (216) 778-2303 (CHRP)
FAX: (216) 368-3118 (VA), (216) 778-5935 (CHRP)


Biosketch
Curriculum Vitae

Selected Publications
Rose, J. H., Bowman, K. F., & Kresevic, D. (2000) Nurse versus family caregiver perspectives on hospitalized older patients: An exploratory study of agreement at admission and discharge. Health Communication, 12 (1). 63-80.

Rose, J. H., O`Toole, E. E., Dawson, N. V., Thomas, C. Connors, A. F., Wenger, N., Phillips, R. S., Hamel, M. B.,Cohen, H. J., & Lynn, J. (2000). Age differences in care practices and outcomes for hospitalized patients with cancer. Journal of the American Geriatrics Society, 48, S25-S32.

Rose, J. H., O`Toole, E. E., Dawson, N. V., Thomas, C., Conners, A. F., Wenger, N., Phillips, R. S., Hamel, M. B., Reding, D. T., Cohen, H. J., Lynn, J. (2000). Generalists and oncologists show similar care practices and outcomes with hospitalized late stage adult cancer patients. Medical Care, 28, 1103-1118.

David S. Rosenbaum, M.D.
Director, Heart & Vascular Research Center
Chief, Division of Cardiology
Professor of Medicine, Biomedical Engineering, Physiology & Biophysics
TEL: (216) 778-2005
FAX: (216) 778-4924

Curriculum Vitae
Heart & Vascular Research Web Page

Research Interest(s)
Mechanisms of cardiac arrhythmias. Areas of special interest include; application of novel imaging technologies (e.g. voltage-sensitive dyes) to investigations of electrical heterogeneities in the heart, cardiac repolarization, electrophysiological characterization of genetically engineered mice, electrophysiology of failing and remodeled myocardium, computer modeling of electrical properties in the heart, mechanisms of electrical alternans and arrhythmogenesis, and prediction and prevention of sudden cardiac death.

Selected Publications
Wan X, Laurita KR, Pruvot E, Rosenbaum DS. Molecular correlates of repolarization alternans in cardiac myocytes. J. Molecular Cellular Cardiology 2005;39:419-428

Eloff BC, Gilat E, Wan X, Rosenbaum DS. Pharmacological modification of cardiac gap junctions to enhance cardiac conduction: Evidence supporting a novel target for antiarrhythmic therapy. Circulation 2003;108:3157-3163

Pastore JM, Rosenbaum DS: Role of structural barriers in the mechanism of alternans-induced reentry. Circulation Research 2000;87:1157-1163.

Poelzing S, Rosenbaum DS. Altered connexin43 expression produces arrhythmia substrate in heart failure. Am J Physiol 2004;287:H1762-70

Rosenbaum DS, Jackson LE, Smith JM, Garan H, Ruskin JN, Cohen RJ: Electrical alternans and vulnerability to ventricular arrhythmias. N Engl J Med 1994;330:235-241.

Geoffrey L. Rosenthal, M.D.
Staff Physician, Pediatric Cardiology
Heart & Vascular Center
MetroHealth Medical Center
TEL: (216) 778-2222

Stephen Ruedrich, M.D.
Physician, Psychiatry
MetroHealth Medical Center
Associate Professor
Case Western Reserve University
TEL: (216) 778-4626
FAX: 216 778 8412


Research Interest(s)
Diagnostic assessment of persons with MR/DDPsychopharmacology in persons with MR/DDTreatment of cognitive decline in persons with MR/DDDetermination of competence in persons with MR/DD

Martha Sajatovic, M.D.
Professor of Psychiatry
and Epidemiology and Biostatistics
School of Medicine
Case Western Reserve University
Department of Psychiatry
University Hospitals of Cleveland
TEL: (216) 844-2808
FAX: (216) 844-2742

Biosketch
Curriculum Vitae

Research Interest(s)
Dr. Sajatovic’s research interests have focused on illness outcomes in serious mental illness such as bipolar disorder and schizophrenia, and in the areas of treatment adherence and late-life mental illnesses. She also has research interests in psychopharmacology, women`s mental health. immigrant/minority health, and in mental health rating scales.

Selected Publications
Sajatovic M, Bauer MS, Kilbourne AM, Vertrees JE, Williford W. Self-reported medication treatment adherence among veterans with bipolar disorder. Psychiatric Services, 57(1): 56-62, 2006.

Sajatovic M, Blow FC, Ignacio RV. Psychiatric comorbidity in older adults with bipolar disorder. International Journal of Geriatric Psychiatry. 21(6):582-587, 2006.

Sajatovic M, Valenstein M, Blow FC, Ganoczy D, Ignacio RV. Treatment adherence with antipsychotic medications in bipolar disorder. Bipolar Disorders, 8(3): 232-41, 2006.

jatovic M, Jenkins JH. Is antipsychotic medication stigmatizing for people with mental illness? International Review of Psychiatry 19(2) 107-12, 2007.

Sajatovic M, Valenstein M, Blow F, Ganozcy D, Ignacio R. Treatment adherence with lithium and anticonvulsant medications among patients with bipolar disorder. Psychiatric Services, 58(6): 855-863, June 2007.

Jeffrey Schelling, M.D.
Professor of Medicine
Case Western Reserve University
Director, Division of Nephrology and Hypertension
MetroHealth Medical Center
TEL: (216) 778-4993, (216) 778-4159
FAX: (216) 778-4321, (216) 778-8248


Curriculum Vitae
Biosketch
Laboratory Web Page

Research Interest(s)
The primary interest of my lab is investigation of cellular and molecular mechanisms regulating chronic renal diseases. Much of the laboratory effort is devoted toward understanding the pathogenesis of tubular atrophy, which predicts chronic kidney disease progression. Approaches to these studies focus on apoptosis and cell survival pathways. We have determined that activation of the renal tubular epithelial cell NHE1 Na+/H+ exchanger promotes cell survival, in part by functioning as a scaffold for assembly of signaling complexes. Additional interests of the lab include interrogation of αvß8 integrin function in mesangial cells. Using in vitro and animal model systems, we are investigating the possibility that αvß8 directs small molecular weight G-protein pathways, which may regulate mesangial cell differentiation and/or glomerular capillary function. Finally, we are engaged in collaborative projects, which employ high throughput screening methods to identify diabetic nephropathy susceptibility genes.

Selected Publications
Schelling JR, Abu Jawdeh BG. Regulation of cell survival by Na+/H+ exchanger-1 (NHE1). Am J Physiol Renal Physiol 295:F625-F632, 2008. Go to Publication

Schelling JR, Abboud HE, Nicholas SB, Pahl MV, Sedor JR, et al, on behalf of the Family Investigation of Nephropathy and Diabetes Research Group. Genome-wide scans for estimated GFR in multi-ethnic diabetic populations: The Family Investigation of Diabetes and Nephropathy. Diabetes 57:235-243, 2008. Go to Publication

Lakhe-Reddy S, Khan S, Konieczkowski M, Jarad G, Wu KL, Reichardt LF, Takai Y, Bruggeman LA, Wang B, Sedor JR, Schelling JR. ß8 integrin binds RhoGDI-1 and activates Rac1 to inhibit mesangial cell myofibroblast differentiation. J Biol Chem 281:19688-19699, 2006. Go to Publication

Wu KL, Khan S, Lakhe-Reddy S, Jarad G, Obejero-Paz CA, Mukherjee A, Konieczkowski M, Sedor JR, Schelling JR. The NHE1 Na+/H+ exchanger recruits ERM proteins to regulate Akt-dependent cell survival. J Biol Chem 279:26280-26286, 2004. Go to Publication

Jarad G, Wang B, Miao H, Khan S, Wu K, DeVore J, Nishimura SL, Wible BA, Konieczkowski M, Sedor JR, Schelling JR. Fas activation induces renal tubular epithelial cell ß8 integrin expression and function in the absence of apoptosis. J Biol Chem 277:47826-47833, 2002. Go to Publication

William P. Schilling, Ph.D.
Associate Professor
Physiology and Biophysics, CWRU
Bioscientific Staff
TEL: (216) 778-8965
FAX: (216) 778-8997

Curriculum Vitae

Research Interest(s)
Calcium signaling in vascular endothelial cells and the role of ion channels in cell death.

Selected Publications
Estacion, M., Sinkins, W.G., and Schilling, W.P. Regulation of Drosophila TrpL channels by phospholipase C-dependent mechanisms. J. Physiol. (Lond.) 2001, 530.1: 1-19.

Estacion, M. and Schilling, W.P. Maitotoxin-induced cell death and membrane blebbing in vascular endothelial cells. BMC:Physiology, 2001, 1:2.

Goel, M., Garcia, R. Estacion, M. and Schilling, W.P. Regulation of Drosophila TRPL channels by immunophilin dFKBP59. J. Biol. Chem. 2001, In Press.

David Schnell, M.D.
Physician, Cardiology
Brooklyn Medical Group
MetroHealth Medical Center
Assistant Professor
Case Western Reserve University
TEL: (216) 778-3875

Dianne Schubeck, M.D.
Physician, OB/GYN
MetroHealth Medical Center
Assistant Professor
Case Western Reserve University
TEL: (216) 778-7758

John Sedor, M.D.
Professor of Medicine and Physiology & Biophysics,
School of Medicine, Case Western Reserve University
Vice President of Research,
Department of Medicine,
MetroHealth Medical Center
TEL: (216) 778-4993
FAX: (216) 778-4978


Biosketch
Laboratory Web Page
Research Highlights

Research Interest(s)
We focus on progressive kidney disease mechanisms. The overall goal of the lab is to define the clinical, cellular and genetic bases of kidney disease in order to identify new therapies and diagnostic tests. Current projects include identification of nephropathy susceptibility genes and defining mechanisms of kidney disease progression using in vitro (cell culture) and animal models. Using gene discovery assays, the lab has discovered a protein that appears to critically regulate kidney filtration function (WTIP) and is now characterizing this novel protein’s function and looking for mutations in its DNA sequence in families with multiple cases of kidney disease.Keywords: protein-protein interaction, proteomics, genomics, cell-cell adhesion, podocyte, cytoskeletonTechniques used: Cell Culture, Molecular biology, LC/MS, Protein Chemistry, Phage Display Immunohistochemistry, Protein Expression, DNA library construction, PCR differential display, SAGE, expression profiling, 2-hybrid system, genetic-epidemiological statistical approaches.

Selected Publications
Srichai, M.B., M. Konieczkowski, S. Barathan, P. S. Hayden, S. Khan, P. Mundel, S.B. Lee, L.A. Bruggeman, J.R. Schelling, and J.R. Sedor. A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus. J. Biol. Chem. 279: 14398-408, 2004. Go to Publication

Liu, J., L. Zhang, D. Wang, H. Shen, M. Jiang, P. Mei, P.S. Hayden, J.R. Sedor and H. Hu. Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with Slit3-deficiency in mice. Mech. Dev. 120:1059-70 2003. Go to Publication

Knowler, W.C., J. Coresh, R.C. Elston, B.I. Freedman, S.K. Iyengar, P.L. Kimmel, J. Olson, R. Plaetke, J.R. Sedor, and M.F. Seldin on behalf of the Family Investigation of Nephropathy and Diabetes Research Group. The family investigation of diabetes and nephropathy (FIND). Design and Methods. J. Diabetes Complications, in press, 2004.

Hayden, P.S., M.A. El-Meanawy, J.R. Schelling, and J.R. Sedor. DNA expression analysis: SAGE (Serial Analysis of Gene Expression), microarrays and kidney disease. Curr. Opin. Nephrol. Hypertens. 12: 407-414, 2003. Go to Publication

Iyengar, S.K., K.A. Fox, M. Schachere, F. Manzoor, M.E. Slaughter, A.M. Covic, S.M. Orloff, P.S. Hayden, J.M. Olson, J.R. Schelling, and J.R. Sedor. Linkage analysis of candidate loci for end stage renal disease due to diabetic nephropathy. J. Amer. Soc. Neph. 14: S195-S201, 2003. Go to Publication

Eileen L. Seeholzer, M.D.
Assistant Professor of Medicine
Case Western Reserve University
Director, Weight Management Center
MetroHealth Medical Center
Center for Health Care Research and Policy
TEL: (216) 778-7433

Biosketch
Curriculum Vitae

Selected Publications
Toossi Z, Mincek M, Seeholzer E, Fulton SA, Hamilton BD, Hirsch CS. Modulation of IL-12 by transforming growth factor-beta (TGF-beta) in Mycobacterium tuberculosis-infected mononuclear phagocytes and in patients with active tuberculosis. J Clin Lab Immunol 1997; 49(2):59-75.

Robert T. Segraves, M.D., Ph.D.
Chairperson, Dept. of Psychiatry
MetroHealth Medical Center
Professor
Case Western Reserve University
TEL: (216) 778-3634
FAX: -(216) 7785907


Curriculum Vitae

Research Interest(s)
Sexual disordersAffective disordersGeriatric [Psychiatry

Selected Publications
. Segraves R & Woodard T. Female hypoactive sexual desire disorder: history and current status. J Sex Med , 2006, 3 , 408-418.

Segraves R, Lee J, Stevenson R, Walker D, Wang C, Dickson R. Tadalafil for treatment of erectile dysfunction in men on antidepressants. J Clin Psychopharmacol ( In Press )

Riley A & Segraves R. Treatment of premature ejaculation. Int J Clin Pract , 2006, 60, 694-697

Segraves R, Clayton A, Croft H, Wolf A, Warnock J, Segraves K,. Bupropion for the treatent of hypoactive sexual desire disorder. J Clin Psychopharmacol 2004, 24, 339-342.

Ashwini R. Sehgal, M.D.
Director, The Center for Reducing Health Disparities
Associate Professor of Medicine, Biomedical Ethics, and Epidemiology and Biostatistics
Physician, Division of Nephrology
TEL: (216) 778-7728
FAX: (216) 778-8401

Biosketch
Curriculum Vitae

Research Interest(s)
Identifying and overcoming barriers to quality of care, Complex health interventions, Adequacy of hemodialysis, Nutrition in renal failure, Access to kidney transplantation, Medical activism.

Selected Publications
Sehgal AR, Leon JB, Siminoff LA, Singer ME, Bunosky LM, Cebul RD. Improving the quality of hemodialysis treatment: A community-based randomized controlled trial to overcome patient-specific barriers. Journal of the American Medical Association. 2002;287:1961-1967.

Goyal M, Mehta RL, Schneiderman LJ, Sehgal AR. Economic and health consequences of selling a kidney in India. Journal of the American Medical Association. 2002;288:1589-1593.

Sehgal AR. Do quality improvement efforts reduce race and gender disparities in health outcomes? Journal of the American Medical Association. 2003;289:996-1000.

Richard F. Silver, M.D.
Associate Professor of Medicine
Associate Professor of Infectious Diseases
Case Western Reserve University


Research Interest(s)
Dr. Silver is interested in protective human immunity to Mycobacterium tuberculosis and in development of assays for assessment of the virulence M. tuberculosis in human model systems. Current studies focus on the ability of lymphocytes to limit intracellular growth of virulent M. tuberculosis within blood monocytes and alveolar macrophages. Studies have assessed the capacity of CD4+ and CD8+ T-cells, and of natural killer cells (NK cells) to mediate killing of intracellular M. tuberculosis . Correlation has been made between the capacities of these lymphocyte subsets inhibit intracellular M. tuberculosis and their ability to produce activating cytokines, and to mediate lytic and apoptotic killing of M. tuberculosis-infected mononuclear phagocytes. Dr. Silver’s laboratory is also investigating the ability of M. tuberculosis-specific immune responses to be mobilized to the lungs of PPD-positive subjects using a novel bronchoscopic antigen-challenge protocol. Dr. Silver’s laboratory has demonstrated that PPD challenge results in recruitment of antigen specific Th1-like CD4+ T-cells to the lungs of individuals with immunity to M. tuberculosis. This approach has also demonstrated the importance of resident memory cells in initiating chemokine responses to M. tuberculosis within the lung. Local antigen challenge may be useful in evaluating and optimizing new strategies for vaccination against tuberculosis. More generally, these studies offer a means to characterize the mechanisms involved in development of Th1-like responses in the human lung. In addition, Dr. Silver has utilized a model of low-level infection of human monocytes and alveolar macrophages to assess the virulence of M. tuberculosis. In this system, the capacity for intracellular growth of M. tuberculosis isolates appears to correlate with molecular epidemiologic assessments of strain virulence. Current studies involve both assessment of the alterations in intracellular growth seen in recombinant organisms in which specific candidate virulence genes have been disrupted, and comparison of the growth of clinical isolates of M. tuberculosis obtained from well-characterized households in Uganda.

Selected Publications
Q Li, CC Whalen, R Larkin, L Zukowski, J Albert, MD Cave, and RF Silver. “Differences in rate and variability of intracellular growth of a panel of clinical isolates of Mycobacterium tuberculosis within a human monocyte model ”, Infection and Immunity, 2002, 70: 6489-6493.

F Hoft, S Worku, B Kampmann, C Whalen, JJ Ellner, CS Hirsch, RB Brown, R Larkin, Q Li, H Yun, and RF Silver. “Investigation of the relationships between immune-mediated inhibition of mycobacterial growth and other potential surrogate markers of protective TB immunity”, J. Inf. Diseases, 2002, 186: 1448-1457.

RF Silver, Q Li, L Zukowski, S Kotake, F Pozuelo,A Krywiak, and R Larkin“Recruitment of antigen-specific Th1 responses to the human lung following segmental antigen challenge with Purified Protein Derivative of M. tuberculosis”, Am. J. Resp. Cell. and Mol. Biol., 2003, 29: 117-123.

J Walrath,, L Zukowski, A Krywiak, and RF Silver. “Th1-like resident effector-memory cells and the initiation of pulmonary recall responses to Mycobacterium tuberculosis” (submitted).

Marcia R. Silver, M.D., FACP
Director, Hemodialysis Program
Divison of Nephrology and Hypertension
MetroHealth Medical Center
Associate Professor of Medicine
Case Western Reserve University
TEL: (216) 778-4159
FAX: (216) 778-8248

Curriculum Vitae

Research Interest(s)
Clinical trials
Clinical Nephrology, Hypertension, Dialysis
Chronic Kidney Disease

Selected Publications
Sehgal AR, Snow RJ, Singer ME, Amini SB, DeOreo PB, Silver MR, and Cebul RD. Barriers to adequate delivery of hemodialysis. Am J Kidney Dis 31: 593-601, 1998.

Sehgal AR, Silver MR, Covinsky KE, Coffin R, and Cain JA, for the Medical Review Board of The Renal Network, Inc. Use of standardized ratios to examine variability in hemodialysis vascular access across facilities. Am J Kidney Dis 35:275-281, 2000.

Silver MR and Cain JA, for the Medical Review Board of The Renal Network, Inc. Managing the lifeline: preemptive access management for better outcomes for hemodialysis patients and programs. Advances in Renal Replacement Therapy 7: S45-S55, 2000.

Jeffrey S. Simske, Ph.D.
Staff Scientist
Assistant Professor
TEL: (216) 778-8968, (216) 778-5845
FAX: (216) 778-4321

Curriculum Vitae

Research Interest(s)
My lab is interested in the mechanisms that regulate epithelial polarity and morphogenesis using C. elegans and vertebrate tissue culture model systems. The aim is to understand how cell adhesion and cell junction molecules control the development of three-dimensional structures such as tubules in kidneys and lungs from simple sheets of epithelia. Current research is focused on the characterization of the signaling pathways that regulate cell shape under control of the tetraspan adherens junction protein VAB-9/TM4SF10 in C. elegans and in vertebrates. The long-term goal is to discover and characterize new epithelial polarity determinants.

Selected Publications
Simske, J. S., Koppen, M., Sims, P., Hodgkin, J., Yonkof, A. & Hardin, J. The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans. Nat Cell Biol 5, 619-25 (2003).

Koppen, M., Simske, J. S., Sims, P. A., Firestein, B. L., Hall, D. H., Radice, A. D., Rongo, C. & Hardin, J. D. Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia. Nat Cell Biol 3, 983-91 (2001).

Simske, J. S. & Hardin, J. Getting into shape: epidermal morphogenesis in Caenorhabditis elegans embryos. Bioessays 23, 12-23 (2001).

Charles Smith, M.D.
Director, Cardiothoracic Anesthesia
MetroHealth Medical Center
Professor of Anesthesia
Case Western Reserve University
TEL: (216) 778-3616


Research Interest(s)
My research is primarily focused in the areas of hypothermia, intravenous fluid warming, airway management, pharmacology of neuromuscular relaxants and other anesthesia drugs.

Ethel Smith-Bowen, M.D.
Senior Clinical Instructor, Department of Family Practice
MetroHealth Medical Center
TEL: (216) 778-1951
FAX: (216) 778-3945

Biosketch

Research Interest(s)
Quality Improvement, Education in Quality Improvement and Systems Learning, Preventative Health in Primary Care.

Selected Publications
Improved Patient Access in a Family Practice Clinic at an Academic Medical Center, Seventh International Scientific Symposium at the Thirteenth National Forum on Quality Improvement in Health Care Dec 2001.

Margaret Stager, M.D.
Physician, Dept. of Pediatrics
MetroHealth Medical Center
Assistant Professor
Case Western Reserve University
TEL: (216) 778-2643

Thomas Steinemann, M.D.
Physician, Dept. of Surgery
MetroHealth Medical Center
Associate Professor
Case Western Reserve University
TEL: (216) 778-4253


Research Interest(s)
Ophthalmologic applications of Protein C
Contact lens regulatory issues
refractive surgery

clinical trials : corneal infection, conjunctivitis, dry eye, blepharitis

Kingman P. Strohl, M.D.
Professor of Anatomy
Professor of Oncology
Professor of Medicine
Case Western Reserve University
TEL: (216) 231-3399
FAX: (216) 231-3475


Research Interest(s)
Obstructive sleep apnea is the most common disorder of respiratory control, present in some 2-5% of the population and producing neurocognitive and cardiovascular morbidity. This state-dependent condition has a clear genetic component, with a substantially increased risk for snoring and sleep apnea among relatives of affected individuals. Almost a third of the variance in the severity of sleep apnea in a US population is explained by familial clustering. The pathways by which inheritance could predispose to sleep apnea include anatomic features of the obese condition and of craniofacial form; however, current data suggest that these heritable traits explain only a half of familial cases. Our research focuses on those factors related to respiratory control, namely the control of ventilation and the impact of sleep on ventilatory drive. We are interested in how the elements of ventilatory act and interact to produce repetitive events during sleep, which in turn influence the pathogenesis of illness. Our pre-clinical models suggest genetic risk influences features of dynamic control including the response to changes in chemosensory drive and the response to re-oxygenation, including the appearance of unstable breathing. Thus research has begun to identify a biologic map for causative factors that modulate the physiology of sleep apnea, and provide insight into pathways that could increase (or decrease) the risk of disease progression or that might be pharmacologically influenced to reduce apnea expression.

Selected Publications
Iyengar SK, Stein CM, Russo K, Erokwu BO, Strohl KP. The fa Leptin Receptor Mutation and the Heritability of Respiratory Frequency in a Brown Norway and Zucker Intercross. J Appl Physiol 97(3):811-20, 2004 Epub 2004 Mar 19

Gonsenhauser I, Han F, Wilson CG, Strohl KP, Dick TE. Strain Differences in Murine Ventilatory Behavior Persists after Anesthesia. J Appl Physiol 97(3):888-894, 2004

Friedman L, Haines A, Klann K, Gallaugher L, Salibra L, Han F, Strohl KP. Sleep and Ventilatory Behavior among A/J and C57BL/6J Mouse Strains. J Appl Physiol 97(5):1787-95, 2004.

Mehra R, Strohl KP. Incidence of Serious Adverse Events during Nocturnal Polysomnography. Sleep 27: 1379-83, 2004

Papp KK, Strohl KP. The Effects of an Intervention to Teach Medical Students about Obstructive Sleep Apnea. Sleep Medicine (in press)

Joseph J. Sudano, Jr., Ph.D.
Assistant Professor of Medicine, Case School of Medicine
Senior Researcher, Center For Health Care Research and Policy
Associate Director of Education, Center for Reducing Health Disparities
TEL: (216) 778-1399
FAX: (216) 778-3945

Biosketch
Curriculum Vitae

Research Interest(s)
Disparities in health care access, utilization and health outcomes concentrating on minorities and other vulnerable populations; social determinants of health including community/contextual characteristics; measurement equivalence, validity and item-response theory in cross-cultural health status measurement; culturally-specific health beliefs and behaviors; cognition, intelligence, and education in relationship to health status and health behaviors; structural equation modeling/path analysis in health outcomes research; health related survey data collection and analysis.

Selected Publications
Baker DW, Sudano JJ, Borawski EA, Dor A, Albert JA. 2001. "Lack of health insurance and decline in overall health in late middle age." New England Journal of Medicine 345(15):1106-1112.

Sudano JJ, Baker DW. 2003. "Intermittent lack of health insurance and use of preventive services." American Journal of Public Health 93(1):130-137.

Sudano JJ, Baker DW. 2006. “Explaining U. S. Racial/Ethnic Disparities in Health Declines and Mortality in Late Middle Age: The Roles of Socioeconomic Status, Health Behaviors, and Health Insurance.” Social Science & Medicine 62(4):909-22.

Dor A, Sudano JJ, Baker DW. 2006. “The effect of private insurance on the health of older, working age adults: evidence from the Health and Retirement Study." Health Services Research 41(3 Pt 1): 759-87.

Dennis M. Super, M.D., M.P.H.
Associate Professor, Department of Pediatrics
Case Western Reserve University
Associate Chairman, Pediatric Research
MetroHealth Medical Center
TEL: (216) 778-1213



Research Interest(s)
As both a pediatrician and an epidemiologist, my research interests range from diagnostic test development to the growth and development of children. For example, our past work in the field of gestational diabetes mellitus has shown that one can accurately diagnose gestational diabetes in the first trimester of pregnancy in a high-risk population. In addition, we have shown that non-obese women with gestational diabetes have a lower risk of gestational diabetes in subsequent pregnancies than their obese counterparts. We are currently in the process of developing normative data for the 50 gram glucose tolerance tests in each trimester of pregnancy.

I am also the co-principal investigator of a study funded by NIDA to evaluate the effect of intrauterine exposure to cocaine on the neonate’s cardiovascular system. As part of this study, we are also evaluating the association of cocaine exposure to intrauterine growth retardation by studying the infant’s body composition, placenta morphology, and various fetal growth hormones.

In addition to the above studies, I also serve as both research methodologist and biostatistician to the General Clinical Research Center as well as the Robert Schwartz, M.D., Center for Metabolism and Nutrition. In this capacity, I assist our investigators in the design and analysis of their studies.

Selected Publications
Raghavan CV, Super DM, Chatburn RL, Savin SM, Fanaroff AA, Kalhan SC: Estimation of total body water in very low birthweight (VLBW) infants using bioelectric impedance and [18O] labeled water. Am J Clin Nutr 68:668-674, 1998.

Super DM, Edelberg SC, Philipson EH, Hertz RH, Kalhan SC: Diagnosis of gestational diabetes in early pregnancy. Diabetes Care 14:288-294, 1991.

Philipson EH, Super DM: Gestational diabetes mellitus: Does it recur in subsequent pregnancies? Am J Obstet Gynecol 160:1324-1331, 1989.

Thomas P. Swales, PhD
Director, Psychological Assessment Center
Department of Psychiatry
MetroHealth Medical Center
TEL: (216) 778-3475, 3746, (216) 778-4626
FAX: (216) 778-8412, (216) 778-4439

Web Page

Research Interest(s)
The primary focus of our Center is to provide objective assessment of psychiatric, neurological, and medical conditions through the use of standardized tests of cognitive, behavioral or emotional functioning. We maintain an extensive battery of computer, technician, or patient-administered tests.

Selected Publications
Pillai, J.J., Friedman, L., Stuve, T.A., Trinidad, S., Jesberger, J.A., Lewin, J.S., Findling, R.L., Swales, T.P., Schulz, S.C. (2002). Increased presence of white matter hyperintensities in adolescent patients with bipolar disorder. Psychiatry Research, 114, 51-56.

Ruedrich, S., Swales, T.P., Fossaceca, C., Tolliver, J., Rutkowski, A. (1999). The effect of divalproex sodium on aggression and self-injurious behaviour in adults with intellectual disability: a retrospective review. Journal of Intellectual Disability Research, 43(Pt.2), 105-111.

Kenny, J.T., Friedman, L., Findling, R.L., Swales, T.P., Strauss, M.E., Jesberger, J.A., Schulz, S.C. (1997). Cognitive impairment in adolescents with schizophrenia. American Journal of Psychiatry, 154(11), 1613-1615.

Moore, L.H., van Gorp, W.G., Hinkin, C.H., Stern, M.J., Swales, T., Satz, P. (1997). Subjective complaints versus actual cognitive deficits in predominantly symptomatic HIV-1 seropositive individuals. Journal of Neuropsychiatry and Clinical Neuroscience, 9(1), 37-44.

Gay, C.L., Armstrong, F.D., Cohen, D., Scott, G.B., Lai, S., Hardy, M.D., Swales, T.P., Morrow, C.J., & Scott, G.B. (1995). The effects of HIV on cognitive and motor development in children born to HIV- seropositive women with no reported drug use: Birth to 24 months. Pediatrics, 96(6), 1078-1082.

Nimish Thakore, M.D.
Physician, Neurology
MetroHealth Medical Center
Instructor
Case Western Reserve University
TEL: (216) 778-3958


Research Interest(s)
Neuromuscular disorders, stroke

Zahra Toossi, M.D.
Professor of Medicine
Division of Infectious Diseases
Case Western Reserve University
TEL: (216) 368-4844


Research Interest(s)
Primary: Study of the basis for the dysregulation of the immune response during human tuberculosis with specific focus on cytokine responses to M. tuberculosis and its components, and mononuclear phagocytic effector mechanisms.

Secondary: Study of the impact of tuberculosis on HIV disease with specific focus on mechanisms by which activation of mononuclear cells during tuberculosis and by M. tuberculosis and its products enhance expression of HIV by latently – or newly infected cells.

Selected Publications
Ribeiro-Rodrigues R, Resende Co T, Johnson JL, Ribeiro F, Palaci M, Sa RT, Maciel EL, Pereira Lima FE, Dettoni V, Toossi Z, Boom WH, Dietze R, Ellner JJ, Hirsch CS. Sputum cytokine levels in patients with pulmonary tuberculosis as early markers of mycobacterial clearance. Clin diagn Lab Immunol. 9:818-23; 2002.

Collins KR, Qionones-Mateu ME, Wu M, Luzze H, Johnson JL, Hirsch CS, Toossi Z, Arts EJ. Human immunodeficiency virus type 1 (HIV-1) quasispecies at the sites of Mycobacterium tuberculosis infection contribute to systemic HIV-1 heterogeneity. J virol. 76:1697-706, 2002.

Aung H, Sherman J, Tary-Lehman M, Toossi Z. Anaylsis of transforming growth factor-beta 1 (TGF-beta1) expression in human monocytes infected with Mycobacterium avium at a single cell level by ELISPOT assay. J Immunol Methods. 1;259:25-32, 2002.

Joan Trey, M.D.
Physician, Hematology & Oncology
MetroHealth Medical Center
Associate Professor
Case Western Reserve University
TEL: (216) 778-5802


Research Interest(s)
Clinical research in breast cancer.

Ronald J. Triolo, Ph.D.
Assistant Professor
Departments of Orthopaedics and Biomedical Engineering
Case Western Reserve University
Principal Investigator,
Cleveland VA Center of Excellence in FES
TEL: (216) 778-7877


Curriculum Vitae

Research Interest(s)
Dr. Triolo’s research interests include: the development and clinical application of neural prostheses, biomechanics and the control of movement, rehabilitation engineering, and the assessment of assistive technology. His work focuses on the use of functional neuromuscular stimulation (FNS) to assist persons with spinal cord injuries with basic mobility functions such as standing, transfers, stepping, and balance.

Selected Publications
Triolo R. Introduction to the single-topic issue on functional electrical stimulation. J Rehab Res Dev. 2001 Nov-Dec;38(6):vi-ix.

Davis JA Jr, Triolo RJ, Uhlir J, Bieri C, Rohde L, Lissy D, Kukke S. Preliminary performance of a surgically implanted neurprosthesis for standing and transfers--where do we stand? J Rehabil Res Dev. 2001 Nov-Dev;38(6):609-617.

Triolo RJ, Liu MQ, Kobetic R, Uhlir JP. Selectivity of intramuscular stimulating electrodes in the lower limbs. J Rehabil Res Dev. 2001 Sep-Oct;38(5):533-544.

Terrence G. Tulisiak, M.D.
Staff Physician, Cardiology
Assistant Professor
Case Western Reserve University
TEL: (216) 778-5253, (330) 725-6629

Heather Vallier, M.D.
Physician, Dept. of Orthopaedics
MetroHealth Medical Center
Asssistant Professor
Case Western Reserve University
TEL: (216) 778-7434

Mark E. Votruba, Ph.D.
Assistant Professor of Economics, Case Weatherhead School of Management
Assistant Professor of Medicine, Case School of Medicine
Director, Health Economics Research Unit
Center For Health Care Research and Policy
TEL: (216) 778-2876 (Metro), (216) 368-4296 (CWRU)
FAX: (216) 778-3945 (Metro)

Biosketch
Curriculum Vitae

Research Interest(s)
Health Economics: allocation of medical resources, incentives for care, insurance markets. Public Economics: social program participation, social interactions effects.

Selected Publications
Tsai AC, Votruba M, Bridges JF, Cebul RD. Overcoming bias in estimating the volume-outcome relationship. Health Serv Res 2006;41(1):252-264.

Bailit J., Votruba M. Medical Cost Savings Associated with 17 Alpha Hydroxyprogesterone Caproate. Am J Obstet Gynecol 2007; 196(3):219.e1-e7.

Votruba ME, Cebul RD. Redirecting patients to improve stroke outcomes: implications of a volume-based approach in one urban market. Med Care 44(12):1129-1136.

Katzan IL, Dawson NV, Thomas CL, Votruba ME, Cebul RD. The cost of pneumonia after acute stroke. Neurology 2007; 68:1938-1943.

Thomas Vrobel, M.D.
Associate Professor of Medicine
Director, Coronary Care Unit
TEL: (216) 778-5253
FAX: (216) 778-3927


Research Interest(s)
Acute Coronary Care; Interventional Cardiology.

Selected Publications
Brener SJ, Zeymer U, Adgey AAJ, Vrobel TR, Ellis SG, Neuhaus KL, Juran N, Ivanc TB, Ohman EM, Strony J, Kitt M, Topol EJ, for the INTRO AMI Investigators: Eptifibatide and low-dose tissue plasminogen activator in acute myocardial infarction. The Integrilin and Low-Dose Thrombolysis in Acute Myocardial Infarction (INTRO AMI) Trial. J Am Coll Cardiol 2002; 39:377-386.

The Sympony Investigators. Comparison of Sibrafiban with Aspirin for Prevention of Cardiovascular Events after Acute Coronary Symptoms: a Randomized Trial.Lancet 2000; 355: 337-345.

Chang C, Ip MPm Hsu RM, Vrobel TR: Evaluation of a Proposed Panel of Cardiac Markers for the Diagnosis of Acute Myocardial Infarction in Patients with Atraumatic Chest Pain. Arch Pathol Lab Med 1998; 110: 320-324.

Xiaoping Wan, Ph.D.
Staff Scientist
TEL: (216) 778-7367
FAX: (216) 778-1261

Curriculum Vitae

Research Interest(s)
Mechanisms of cardiac arrhythmias. Areas of special interest include application of patch-clamp technologies and molecular biological methods to investigations of the mechanisms for arrhythmogenesis that involves action potential alternans, Brugada Syndrome, and LQT3.

Selected Publications
X. Wan, S. Chen, A. Sadeghpour, Q. Wang, G.E. Kirsch, Accelerated inactivation in a mutant Na+ channel associated with idiopathic ventricular fibrillation, Am J Physiol 2001;280:H354-H360

X. Wan, Q. Wang, G.E. Kirsch, Functional suppression of sodium channels by b1–subunits as a molecular mechanism of idiopathic ventricular fibrillation, J Mol Cell Cardiol 2000;32:1873-1884.

X. Wan, S.M. Bryant and G. Hart, The effects of [K+]o on regional differences in electrical characteristics of ventricular myocytes in guinea-pig, Experimental Physiology 2000;85:769-774.

Bingcheng Wang, Ph.D.
Associate Professor
Department of Medicine, MetroHealth Medical Center
Department of Pharmacology and the Ireland Cancer Center
Case Western Reserve University
TEL: (216) 778-4256
FAX: (216) 778-4321


Laboratory Web Page

Research Interest(s)
A primary interest of my laboratory is the molecular mechanism governing development and malignant progression of prostate cancer. Currently we are focusing on the role of Eph receptor tyrosine kinases and their ephrin ligands. Eph kinases constitute 25% of the 60 or so receptor tyrosine kinases in human genome. However, their role in tumor development and progression are only beginning to be investigated. We have found that EphA2 kinase is highly expressed in osseous metastasis of human prostate cancer. In vitro, ligand activation of EphA2 inhibits prostate cancer proliferation and migration, suggesting that it may function as a novel tumor suppressor gene. Indeed, our studies using EphA2 knockout model show disruption of EphA2 predispose them to tumor development.

We are exploiting the intrinsic tumor suppressive function of EphA2 in prostate cancer intervention using multidisciplinary strategies including:
1) Characterize novel signal pathways initiated by EphA kinases to identify new points of therapeutic intervention.
2) Investigate the structural bases of EphA2 ectodomain interaction with its cognitive ligands for structure-based drug discovery.
3) Further characterize and optimize peptide and small compound agonists of EphA2 kinase that we have already identified.
4) Develop and perform preclinical assays to evaluate the therapeutic efficacy of EphA2 agonists in athymic mouse xenograft and genetically engineered mouse model systems. A long-term goal is to realize eventual clinical applications of EphA2 agonists in the treatment and prevention of human prostate cancer.

Another interest of my lab is the role of Eph kinases in renal development and physiological function. Several in vitro and in vivo model systems are in use to evaluate how deletion of EphA2 and other Eph kinases may affect branching morphogenesis of renal epithelial cell cultures in vitro and embryonic kidney development in utero. Finally, in the adult kidney, EphA2 is highly expressed in inner medulla and papilla, the most hypertonic site due to urinary concentration. We are currently investigating how EphA2 may contribute to the hypertonic response, which could have important physiological and clinical implications.

Selected Publications
Miao, H., Wei, B.-R., Peehl, D. M., Li, Q., Burnett, E., Alexandrou, T., Sedor, J. R., Schelling, J. R., and Wang, B. (2001). EphA kinase activation inhibits Ras/MAPK pathway. Nature Cell Biology 3:527-530

Miao, H., Nickel, C., Cantley, L. G., Leslie A. Bruggman, 1Laura N. Bennardo and Wang, B. (2003). EphA Kinase Activation Regulates HGF-Induced Epithelial Branching Morphogenesis. Journal of Cell Biology 162:1681-1692.

Miao, H., Guan, J.-L., Shen, T. L., Strebhardt, K., Paquale, E. B., and Wang, B. Inhibition of integrin-mediated cell adhesion and spreading, but not migration requires the catalytic activity of EphB3 kinase. (Published online Nov. 2004). Journal of Biological Chemistry. 280:923-932.

Dhiraj Warman, M.D.
Staff Physician, Cardiology
MetroHealth Medical Center
Case Western Reserve University
TEL: (216) 778-1221, (216) 778-8215

Barbara Wible, Ph.D.
Assistant Professor, Department of Biochemistry
Junior Staff Scientist
TEL: (216) 778-8984
FAX: (216) 778-8282

Curriculum Vitae

Research Interest(s)
Novel mechanisms of ion channel modulation; cloning and characterization of ion channel modulatory proteins using variety of molecular biological and biochemical methods; involvement of potassium channels and associated proteins in apoptosis.

Selected Publications
Wible BA, Yang Q, Kuryshev YA, Accili EA, Brown AM. Cloning and expression of a novel K+ channel regulatory protein, KChAP. J. Biol. Chem. 273:11745-11751, 1998.

Kuryshev YA, Gudz TI, Brown AM, Wible BA. KChAP as a chaperone for specific potassium channels. Am. J. Physiol. 278:C931-C941, 2000.

Kuryshev YA, Wible BA, Gudz, TI, Ramirez, AN, and Brown, AM. KChAPKvb1.2 interactions and their effects on cardiac Kv channel expression. Am. J. Physiol. 281:C290-C299, 2001.

Lance Wilson, M.D.
Physician, Emergency Medicine
MetroHealth Medical Center
Assistant Professor
Case Western Reserve University
TEL: (216) 778-5293

Marc D. Winkelman, M.D.
Staff Physician, Neurology
Associate Professor
Case Western Reserve University
TEL: (216) 778-3958, (216) 778-3388
FAX: (216) 778-8865


Research Interest(s)
Clinical trials of treatment for stroke.

Mojtaba E. Youssefi, M.D.
Staff Physician, Cardiology
Assistant Professor
Case Western Reserve University
TEL: (216) 778-1221, (330) 725-6629

Charles J. Yowler, M.D.
Associate Professor of Surgery
Program Director, Surgical Critical Care Fellowship
Director, Division of Trauma, Critical Care, Burns and Metro Life Flight,Department of Surgery
Director, Comprehensive Burn Care Center
TEL: (216) 778-5627
FAX: (216) 778 1350


Research Interest(s)
Surgical infection, sepsis

Selected Publications
Merlino JI, Yowler CJ, Malangoni MA. Nosocomial infections adversely affect the outcomes of patients with serious intra-abdominal infections. Surg Infection 2004;5; 21-21.

McHenry CR, Berguer R, Ortega RA, Yowler CJ. Recognition, management and prevention of specific operating room catastrophes. J Am Coll Surg 2004; 198: 810-821.

Kwon CC, Gill IS, Fallon WF, Yowler CJ, et al. Delayed operative intervention in the management of traumatic descending thoracic aortic rupture. Ann Thoracic Surg 2002; 74: S 1888-1891.

Brandt CP, Yowler CJ, Fratianne RB. Burns with multiple trauma. Am Surg 2002;68:240-243.

Yowler CJ, Patterson BM, Brandt CP,Fratianne RB. Osteocutaneous pedicle flap of the foot for salvage of below knee amputation level following burn injury. J Burn Care Rehabil 2001:22: 21-25.