Dennis H. Auckley, M.D.
Assistant Professor of Medicine, CWRU
Director, Center for Sleep Medicine
Co-Program Director, Pulmonary and Critical Care Fellowship Program
Co-Program Director, CWRU Sleep Fellowship Program
TEL: (216) 778-2286
FAX: (216) 778-3240

Curriculum Vitae

Research Interest(s)
Sleep disordered breathing and perioperative risk
Sleep disordered breathing and asthma
Treatment of sleep disordered breathing

Selected Publications
Baron J and Auckley D. “Gunshot wound to the head: an unusual complication of sleep apnea and bilevel pressure support.” Accepted for publication in Sleep and Breathing, 2004

Auckley D and Hudgel D. “Management of obstructive sleep apnea syndrome.” Respiratory Care: Principles and Practice. Saunders Co., copyright 2002, Chapter 58: 1139-1150

Auckley D, Crowell R, Heaphy E, Stidley C, Lechner J, Gilliland F, and Belinsky S. “Reduced DNA-dependent protein kinase active is associated with lung cancer.” Carcinogenesis 22 (5):723-727, 2001

Auckley D, Schmidt-Nowara W, and Brown L. “Reversal of sleep apnea hypopnea syndrome in end stage renal disease following kidney transplantation.” American Journal of Kidney Disease 34(4): 739-744, 1999

Mark P. Aulisio, Ph.D.
Director, Clinical Ethics Program
MetroHealth Medical Center
Center for Biomedical Ethics
Case Western Reserve University
TEL: (216) 778-7290
FAX: (216) 778-3360

Biographical Information at Case

Research Interest(s)
Biomedical Ethics, Moral and Political Philosophy, Action Theory

Selected Publications
Mark P. Aulisio, Robert M. Arnold, and Stuart J. Youngner, Ed. Bioethics Consultation: Theoretical and Practical Issues (Baltimore, Maryland: The Johns Hopkins University Press, under contract, expected publication 2001).

The Society for Health and Human Values - Society for Bioethics Consultation Task Force on Standards for Bioethics Consultation, Core Competencies for Health Care Ethics Consultation: The Report of the American Society for Bioethics and Humanities (Lake View, Illinois: American Society for Bioethics and Humanities, 1998), 45 pp.

Mark P. Aulisio, "Standards for Decision Making at the End of Life" in T. May and P. Tudico, eds. Advance Directives and Surrogate Decision Making in Illinois, (Springfield, Illinois: Southern Illinois University School of Medicine Medical Humanities Series, 1999).

vMark P. Aulisio, Robert M. Arnold, and Stuart J. Youngner, "Can There be Educational and Training Standards for Those Conducting Health Care Ethics Consultation?" in D. Thomasma and J. Monagle, ed. Health Care Ethics: Critical Issues for the 21st Century, (Gathersburg, Maryland: Aspen Publishers, 1998), 484-496.

Robert C. Bahler, M.D.
Professor of Medicine
Staff Cardiologist
MetroHealth Medical Center
Case Western Reserve University
TEL: (216) 778-3875
FAX: (216) 778-3927


Research Interest(s)
Noninvasive evaluation of cardiac function.

Selected Publications
Finkelhor RS, Pajouh A, Kett A, Stefanski R, Bosich G, Youssefi M, Bahler RC. Clinical impact of second harmonic imaging and left heart contrast in echocardiographic stress testing. Am J Cardiol 2000;85:740-743.

Bahler RC, Desser D, Finkelhor RS, Brener SJ, Youseffi M. Factors leading to progression of valvular aortic stenosis. Am J Cardiology 1999;84:1044-1048.

Golzari H, Cebul R, Bahler RC. Review Atrial Fibrillation: Restoration and maintenance of sinus rhythm and indications for anticoagulation. Annals of Internal Medicine; 1996;125:311-323.

Sandhu R, Bahler RC. Prevalence of QRS prolongation in a community hospital cohort of patients with heart failure and its relation to left ventricualr systolic dysfunction. Am J Cardiol 2004;93:244-246.

Jennifer L. Bailit, M.D., M.P.H.
Assistant Professor of Reproductive Biology
Department of Obstetrics & Gynecology
Director of Labor and Delivery
Division of Maternal-Fetal Medicine
MetroHealth Medical Center
Center for Health Care Research & Policy Senior Scholar
Women’s Reproductive Health Research Program Scholar
TEL: (216) 778-7341
FAX: (216) 778-8847

Biosketch
Curriculum Vitae

Research Interest(s)
Dr. Bailit’s research focuses on how to assess and improve the quality of obstetrical care. She is interested in using risk-adjusted primary cesarean rates as a marker of quality and in examining factors that are associated with higher quality obstetrical care. Dr. Bailit works with large data sets such as birth certificate data. The overall goal of her research is to improve the quality of obstetrical care.

Selected Publications
Bailit JL, for the NICHD MFMU Network. The MFMU Cesarean Registry: Impact of time of day on Cesarean Complications. American Journal of Obstetrics and Gynecology 2006; 195(4):1132-1137.

Bailit JL, Love TE, Dawson NV, Quality of obstetric care and risk-adjusted primary cesarean rates. American Journal of Obstetrics and Gynecology. 2006, 194:2;401-407.

Boggess K, Bailit JL, Singer M, Parisi, VM, Mercer BM, Projected benefits of universal or scheduled antepartum corticosteroids to prevent neonatal morbidity: A decision analysis. American Journal of Obstetrics and Gynecology. 2005, 193: 4;1415-1423.

Bailit JL, Dierker L, Blanchard M Hsieh, Mercer BM, Outcomes of women presenting in active versus latent phase of spontaneous labor. Obstetrics and Gynecology. 2005, 105; 1:77-79.

Bailit JL, Love T, Mercer, BM Rising Cesarean rates: Are patients sicker? American Journal of Obstetrics and Gynecology. 2004, 191; 3:800-803.

Stanley Ballou, M.D.
Director of Rheumatology
MetroHealth Medical Center
Associate Professor
Case Western Reserve University
TEL: (216) 778-5154, (216) 778-4765
FAX: (216) 778-8376


Research Interest(s)
Lupus Erythematosus

Rachele Berria, M.D., M.S.C.I.
Assistant Professor of Reproductive Biology
Case Western Reserve University
MetroHealth Medical Center
TEL: (216) 778-4466
FAX: (216) 778-2109

Curriculum Vitae

Research Interest(s)
The Role of White Adipose Tissue Adiponutrin During Healthy and Gestational Diabetic Pregnancy

Pregnancy is characterized by a steady decrease of insulin sensitivity. GDM occurs when the pancreatic b cell compensatory function becomes insufficient to counteract the pregnancy-induced insulin resistance. Moreover, pregnancy is characterized by lipogenesis and fat storage in variable entities in early and mid gestation, whereas enhanced lipolysis and fat oxidation (1) take place during late pregnancy. Concomitant changes in the mRNA expression of lipoprotein lipase and hormone-sensitive lipase have been observed (2) during early and late pregnancy, respectively, in WAT. WAT has gained interest in recent years, as it is now known to be a dynamic organ, able to communicate with other key tissues in the body and to secrete a variety of proteins. Adiponutrin was recently identified (3) as a non-secreted adipocyte protein which is regulated by changes in energy balance and associated with lipogenesis. However, its mRNA and protein expression, and relationship with genes involved in energy metabolism has yet to be elucidated during the course of healthy and gestational diabetic pregnancy.

The overall purpose of the ongoing studies is to investigate the role of adiponutrin in white adipose tissue (WAT) during the course of pregnancy. Adiponutrin mRNA expression and protein concentration in WAT are determined, its cross-talk with well-known molecules linked to lipogenesis and lipolysis in WAT is being investigated, together with its repercussion on whole body oxidative fuel utilization, during the early and late stages of healthy and pregnancies with Gestational Diabetes Mellitus (GDM).

Therefore, the specific aims of the ongoing studies are:
1. To evaluate the longitudinal changes in white adipose subcutaneous abdominal cell size and distribution throughout pregnancy.
2. To evaluate longitudinal changes in the expression of adiponutrin during pregnancy.
3. To evaluate mRNA levels of lipogenesis-related molecules (i.e. aP2, CD36, glycerol kinase, SREBP-1, SCD-1, FATP-1) and lipolysis related molecules (ATGL, HSL, ACS, phosphodiesterase 3B) in WAT at different stages in normal and GDM patients.
4. To investigate the presence of cross-talk between adiponutrin and molecules involved in energy metabolism.

Martin-Hidalgo A, Holm C, Belfrage P et al. Lipoprotein lipase and hormone sensitive lipase activity and mRNA in rat adipose tissue during pregnancy. Am J Physiol Endocrinol Metab 266: E930-35, 1994.

Jenkins CM, Mancuso D, Yan W et al. Identification, cloning, expression and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J Biol Chem 279: 48968-75, 2004.

Okereke NC, Huston-Presley L, Amini SB et al. Longitudinal changes in energy expenditure and body composition in obese women with normal and impaired glucose tolerance. Am J Physiol Endocrinol Metab 287: E472-9, 2004.

Selected Publications
Berria R, Gastaldelli A, Lucidi S, Belfort R, DeFilippis E, Easton C, Brytzki R, Cusi K, Jovanovic L and DeFronzo RA. Reduction in Hematocrit Following Pioglitazone Treatment is Related to Decrease in Plasma Free Testosterone, not to Hemodilution in Women with PCOS. Clin Pharmacol and Therapeutics 80(2);105-14, 2006.

Murgia C, Berria R, Minerba L, Malloci B, Daniele C, Zedda P, Ciccotto MG, Sulis S, Murenu M, Tiddia F, Manai M and Melis GB. Gestational Diabetes Mellitus in Sardinia: Results from an early, universal screening procedure. Diab Care 29(7):1713-4, 2006.

Sriwijiktamol A, Christ-Roberts CY, Berria R, Eagan P, Pratipanawatr T, DeFronzo RA, Mandarino LJ and Musi N. Reduced skeletal muscle inhibitor of KappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training. Diabetes 55(3):760-7, 2006.

Berria R, Wang L, Richardson D, Finlayson J, DeFilippis E and Mandarino LJ. Increased Collagen Content in Insulin Resistant Skeletal Muscle Am J Physiol Endocrinol Metab 290:560-5, 2006.

Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo RA, Finlayson J, Kahn R and Mandarino LJ. Coordinated Reduction of Oxidative Metabolism Genes in Mexican-American Subjects with Insulin Resistance and Diabetes: Potential Role of PGC-1 and NRF-1. Proc Natl Acad Sci USA 100:8466-71, 2003.

David J. Birnkrant, M.D.
Associate Professor of Pediatrics, Case Western Reserve University
Head, Pediatric Pulmonology
Director, Student Education
Department of Pediatrics
MetroHealth Medical Center
TEL: (216) 778-4832
FAX: (216) 778-4223


Research Interest(s)
Respiratory complications of pediatric neuromuscular diseases; pediatric noninvasive mechanical ventilation; noninvasive mucus clearance techniques; perinatal asthma risk factors.

Selected Publications
Birnkrant DJ. The assessement and management of the respiratory complications of pediatric neuromuscular diseases. Clin Pediatr 2002; 41: 301-308.

Pope JF, Birnkrant DJ. Noninvasive ventilation to facilitate extubation in a pediatric intensive care unit. J Intensive Care Med 2002; 15: 99-103.

Birnkrant DJ, Pope JF, Eiben RM. Management of the respiratory complications of neuromuscular diseases in the pediatric intensive care unit. J Child Neurol 1999; 14: 139-143.

Birnkrant DJ, Pope JF, Martin JE, Repucci AH, Eiben RM. Treatment of type I spinal muscular atrophy with noninvasive ventilation and gastrostomy feeding. Pediatr Neurol 1998; 18: 407-410.

Pope JF, Birnkrant DJ, Martin JE, Repucci AH. Noninvasive ventilation during percutaneous gastrostomy placement in Duchenne muscular dystrophy. Pediatr Pulmonol 1997; 23: 468-471.

Carol E. Blixen, PhD, RN
Senior Scholar, Center for Health Care Research & Policy
Case Western Reserve University at MetroHealth Medical Center
Adjunct Associate Professor of Medicine
Department of Medicine
Case Western Reserve University
TEL: (216) 283-4134

Biosketch
Curriculum Vitae

Research Interest(s)
Dr. Blixen employs both qualitative and quantitative approaches (mixed methods) to examine the personal, behavioral, and sociocultural issues that impact on patients` medical decision making and adherence to treatment. She is currently looking at predictors of alcohol use among nonharmful drinkers with Hepatitis C.

Selected Publications
Blixen, C., Papp, K., Hull, A. , Rudick, R . & Bramstedt, K. (2007). Developing a mentorship program for clinical researchers. Journal of Continuing Education in the Health Professions. 27(2):22-29.

Stoller, E., Hund, A., Webster, N., Blixen, C., Perzynski, A., McCormick, R., Kanuch, S & Dawson, N. (2006) Alcohol consumption within the context of heapatitis C: A qualitative study of nondependent drinkers. Alcohol and Alcoholism.

Blixen, C., Singh, A., Thacker, H. (2006) Values and beliefs about obesity and weight reduction among African-American and Caucasian Women. Journal of Transcultural Nursing. (3):290-297.

Blixen, C., Singh, A., Xu, M., Thacker, H., & Mascha, E. (2006). What women want: understanding obesity and preferences for primary care weight reduction interventions among African American and Caucasian women. Journal of The National Medical Association. 98 (7):1160-1169

Blixen, C., Bramstedt, K., Hammel, J. & Tilley, B. (2004) Health education via a nurse-run telephone self-management program for older adults with osteoarthritis: A pilot study. Journal of Telemedicine and Telecare. 10 (1), 44-49.

Andrea Bonny, M.D.
Staff Physician, Pediatrics
MetroHealth Medical Center
Assistant Professor
Case Western Reserve University
TEL: (216) 778-3065

Arthur Brown, M.D., Ph.D.
Sr. Staff Scientist
Professor, Physiology and Biophysics
TEL: (216) 778-5960
FAX: (216) 749-3889

Curriculum Vitae

Research Interest(s)
Ion channels are pores in cell membranes that transport ions at high rates. Ion channels are widespread and comprise about 15% of all known drug targets. We study their structure-function relationships, processing, regulation, genetics, and relation to disease (channelopathies). Modifier genes for hereditary and acquired (drug-induced) long QT syndrome are presently being pursued. The lab has also developed a reversible model of heart failure to study arrhythmias in this disease.

Selected Publications
Ficker E, Taglialatela M, Wible BA, Henley CM, Brown AM. Spermine and spermidine as gating molecules for inward rectifier K+ channels. Science. 1994 Nov 11;266(5187):1068-1072.

Wible BA, Yang Q, Kuryshev YA, Accili EA, Brown AM. Cloning and expression of a noval K+ channel regulatory protein, KChAP. J Biol Chem. 1998 May 8;273(19):11745-11751.

Kuryshev YA, Wible BA, Gudz Ti, Ramirez AN, Brown AM. KChAP/Kvb1.2 interactions and their effects on cardiac Kv channel expression. Am J Physiol Cell Physiol. 2001 Jul;281(1):C290-C299.

Leslie Bruggeman, Ph.D.
Associate Professor
Department of Medicine, MetroHealth Medical Center
Center for AIDS Research
Case Western Reserve University
TEL: (216) 778-7603
FAX: (216) 778-4321


Curriculum Vitae

Research Interest(s)
Molecular and cellular biology of chronic kidney diseases. Areas of special interest include: pathogenesis of HIV-associated nephropathy; transcriptional regulation of HIV-1 and eukaryotic gene expression; podocyte cell biology; transcriptional regulation during epithelial cell differentiation and in kidney development. In vitro modeling of the glomerular filtration barrier.

Selected Publications
Bruggeman, L. A., S. Martinka, and J. S. Simske. Expression of TM4SF10, a claudin/EMP/PMP22 family cell junction protein, during mouse kidney development and podocyte differentiation. Dev. Dyn. 236:596-605 (2007).

Ross, M. D., S. Martinka, A. Mukherjee, J. R. Sedor, C. Vinson, and L. A. Bruggeman. Math6 expression in kidney development and altered expression in a mouse model of glomerulosclerosis. Dev. Dyn. 235:3102-3109 (2006).

Martinka, S. and L. A. Bruggeman. Persistent NF-kB activation in renal epithelial cells in a transgenic mouse model of HIV-associated nephropathy. Am. J. Physiol. Renal Physiol. 290: F657-665 (2006).

Ross, M. J., S. Martinka, V. D. D’Agati, and L. A. Bruggeman. NF-kB regulates Fas-mediated apoptosis in HIV-associated nephropathy. J. Am. Soc. Nephrol. 16: 2403-2411 (2005).

Gharavi A. G., T. Ahmad, R. Wong, R. Hooshyar, J. Vaughn, S. Oller, R. Z. Frankel, L. A. Bruggeman, V. D. D`Agati, P. E. Klotman, and R. P. Lifton. Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3. Proc. Natl. Acad. Sci. 101:2488-2493 (2004).

Kevin D. Bunting, Ph.D.
Associate Professor of Medicine
Department of Medicine, Division of Hematology/Oncology
Case Western Reserve University
TEL: (216) 368-5694
FAX: (216) 368-1166


Research Interest(s)
My main area of research continued in the field of hematopoietic stem cell biology. Since these cells are potential targets for treating a wide variety of blood diseases, understanding the basic mechanisms regulating their proliferation, differentiation, self-renewal, mobilization, and migration is extremely important. These processes determine the efficacy of a stem cell transplant and they are directly relevant for possible clinical application in cell and gene therapy. We take a genetics approach to the study of signal transduction pathways and modulation of extracellular matrix interactions of stem cells. These studies heavily use transgenic and knockout mouse models for various genes of interest. This work is also directly relevant for the Case Cancer Center and the Center for Stem Cell and Regenerative Medicine, both of which I am actively involved.

There are two major areas of research that are funded by NIH R01 grants.
1. R01DK059380 - JAK/STAT Signaling in Hematopoietic Stem Cells – the purpose of this work is to define the role of two specific signal transducer and activator of transcription (STAT) family members in hematopoiesis. We are focused on STAT3 and STAT5 because these two factors are regulated by early acting hematopoietic cytokines. The STAT5 project is most well developed (Bunting et al., Blood, 2002; Bradley et al. Blood 2002; Bradley et al. Blood 2004). We have demonstrated a severe competitive repopulating defect in mice in which full-length STAT5a and STAT5b have been deleted. Current studies have focused on a remaining endogenous N-terminal truncated STAT5 alternative reading frame that is expressed at very low levels in these mice. In certain cell types, such as mast cells, we find that the truncated form is selected for and can confer unique cytokine responsiveness to stem cell factor (SCF). Ongoing studies will address the role of STAT5 in SCF responses and possible implications in adhesion, migration, or homing of stem cells. We have also obtained and are currently characterizing true null mice in collaboration with Lothar Hennighausen at the NIH.

2. R01HL073738 - Role of TIMPs in Hematopoietic Stem Cell Biology – the purpose of this work is to define the role of the tissue inhibitor of matrix metalloproteinase (TIMP)/matrix metalloproteinase (MMP) balance in controlling hematopoietic stem cell engraftment. We have developed retroviral vector systems for overexpression of TIMP-1, TIMP-2, and MMP-9 in wild-type and TIMP-1-/- mice. These studies will determine whether TIMPs have MMP-independent growth factor activity in regulating early hematopoiesis. Also, these studies will determine the effects of transgenic MMP-9 on the early engraftment and mobilization of hematopoietic stem and progenitor cells. MMP-9 release following cytokine or chemokine induced mobilization is believed to play a role in release of stem cells from the bone marrow niche, however, MMP-9 transgenic mice have never been reported. Further studies will address the physiological role of TIMP-1 as a negative regulator of MMP-9 under conditions of hematopoietic stress.

Selected Publications
Bradley, H.L., Hawley, T.S., Bunting, K.D. Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hemapoietic stem cells. Blood, (100); 3983-89, 2002.

Bradley, H.L., Couldrey, C., Bunting, K.D. Hematopoietic-repopulating defects from STAT5-deficient bone marrow are not fully accounted for by loss of thrombopoietin responsiveness. Blood, 103; 2965-72, 2004.

Haviernik, P. Lahoda, C., Bradley, H.L., Hawley, T.S., Ramezani, A., Hawley, R.G., Stetler-Stevenson, M., Stetler-Stevenson, W.G., Bunting, K.D. Tissue inhibitor of matrix metalloproteinase-1 overexpression in M1 myeloblasts impairs IL-6-induced differentiation. Oncogene (23); 9212-19, 2004.

James W. Campbell, M.D.
Chairperson, Director, Geriatric Health
Physician, Family Practice
MetroHealth Medical Center
Professor
Case Western Reserve University
TEL: (216) 778-8084

Patrick M. Catalano, M.D.
Chairman, Department of Obstetrics & Gynecology
MetroHealth Medical Center
Professor, Department of Reproductive Biology
Case Western Reserve University
Schwartz Center for Metabolism and Nutrition
MetroHealth Medical Center
TEL: (216) 778-7341, (216) 778-4876
FAX: (216) 778-1574


Curriculum Vitae

Research Interest(s)
The long range goals of our studies are to evaluate mechanisms related to insulin resistance in pregnancy and short and long term effects on the fetus. Currently our grant support is focused on evaluating mechanisms related to insulin resistance in maternal skeletal muscle and adipose tissues. Biopsies are taken prior to conception and again in early and late gestation, and evaluated for alterations in the insulin signaling cascade as they relate to the physiological changes in glucose and lipid insulin sensitivity. Recently, we have begun evaluation of gene expression in placental tissue as a potential signal for alteration of maternal nutrients resulting in excessive fetal growth and macrosomia. Additionally, we have ongoing long-term studies evaluating infants of women with normal glucose tolerance and gestational diabetes. We are evaluating these children’s insulin sensitivity and body composition. The underlying hypothesis is that the altered metabolic milieu of a diabetic pregnancy not only increases the risk of adiposity at birth, but also is a long-term risk for adolescent obesity and glucose intolerance. Lastly, in the clinical trial arena, we are a participant in the Multicenter National Study of Hyperglycemia and Adverse Perinatal Outcome (HAPO) in order to determine which values on an oral glucose tolerance are associated with maternal and fetal perinatal morbidity. All of the above studies are currently funded through the National Institutes of Health.

Selected Publications
CATALANO PM, Kirwan JP, Hauguel-de Mouzon S, King J. Gestational Diabetes and Insulin Resistance: Its role in the Short and Long Term Implications for Mother and Fetus. Am J Clin Nutr 133:1674S-1683S, 2003.

CATALANO PM, Thomas A, Huston-Presley L, Amini SB. Increased fetal adiposity: A very sensitive marker of abnormal in-utero development. Am J Obstet & Gynecol, 189:1698-704, 2003.

Durnwald C, Huston-Presley L, Amini S, CATALANO PM. Evaluation of body composition of large for gestational age infants of women with gestational diabetes compared with women with normal glucose tolerance. Am J Obstet Gynecol, 2004 (In Press)

Okereke N, Huston-Presley L, Amini SB, Kalhan S, CATALANO PM. Longitudinal changes in energy expenditure and body composition in obese women with normal and impaired glucose tolerance. Am J Physiol: Endocrin & Metab, 2004 (In Press)

Ehrenberg HM, Mercer, BM, CATALANO PM. The influence of obesity and diabetes on neonatal macrosomia. AJOG, 2004 (In press)

Grace Cater, M.D.
Staff Physician, Cardiology
Assistant Professor
Case Western Reserve University
TEL: (216) 778-2431


Research Interest(s)
General cardiology,
Non-Invasive Cardiology,
Cardiac Imaging

Randall D. Cebul, M.D.
Professor of Medicine, Epidemiology and Biostatistics
Director, Center for Health Care Research & Policy
TEL: (216) 778-3902
FAX: (216) 778-3945

Biosketch
Curriculum Vitae

Research Interest(s)
Dr. Cebul studies and applies methods in epidemiology and the decision sciences to examine and improve health care delivery. Areas of special emphasis include clinical policy-relevant research and decision support for preventive services and chronic illnesses. Current studies focus on diabetes and cerebrovascular disease.

Selected Publications
Votruba ME, Cebul RD. Redirecting patients to improve stroke outcomes: implications of a volume-based approach in one urban market. Med Care. 2006; 44 (12): 1129-1136

Murray PK, Dawson NV, Thomas CL, Cebul RD. Are we selecting the right patients for stroke rehabilitation in nursing homes? Arch Phys Med Rehabil. 2005;86(5):876-880.

Murray PK, Love TE, Dawson NV, Thomas CL, Cebul RD. Rehabilitation services following the implementation of the nursing home prospective payment system: differences related to patient and nursing home characteristics. Medical Care 2005 Nov;43(11):1109-15.

Katzan IL, Cebul RD, Baker DW, et.al. The effect of pneumonia on mortality among patients hospitalized for acute stroke. Neurology. 2003; 60:620-625.

Baker DW, Einstadter D, Thomas CL, Husak SS, Gordon NH, Cebul RD. Mortality trends during a program that publicly reported hospital performance. Med Care. 2002; 40: 879-890.

John Chae, M.D., M.E.
Associate Professor of PM&R
Director of Research
Case School of Medicine
Associate Professor of Biomedical Engineering
Case School of Engineering
Associate Director of Clinical Affairs
Cleveland Functional Electrical Stimulation Center
TEL: (216) 778-3472
FAX: (216) 778-1653


Curriculum Vitae

Research Interest(s)
Dr. Chae`s research focuses on the application of neuromuscular electrical stimulation to restore upper and lower extremity motor function in hemiplegia. The specific areas of focus include 1) treatment of shoulder subluxation and pain, 2) facilitation of motor recovery 3) development and implementation of neuroprostheses and relationship between neurophysiology, motor impairment and physical disability.

Selected Publications
Yu DT, Chae J, Walker ME et al. Intramuscular neuromuscular electrical stimulation for post-stroke shoulder pain: A multi-center randomized clinical trial. Arch Phys Med Rehabil 2004; 85: 695-704.

Chae J, Hart R. Intramuscular hand neuroprosthesis for chronic stroke survivors. Neurorehabil Neural Repair 2003; 17: 109-117.

Chae J, Yang G, Labatia I. Upper limb motor function in chronic hemiparesis: Concurrent validity of the Arm Motor Ability Test. Am J Phys Med Rehabil 2003; 82: 1-8.

Chae J, Yang G, Park BK, Labatia I. Muscle weakness and co-contraction in hemiparesis: Relationship to motor impairment and physical disability. Neurorehabil Neural Repair 2002: 16: 241-248.

Chae J, Yang G, Park BK, Labatia I. Delay in initiation and termination of muscle contraction, motor impairment and physical disability in upper limb hemiparesis. Muscle Nerve 2002; 25: 568-575.

Michael W. Cho, Ph.D.
Assistant Professor of Medicine
Department of Medicine,
Division of Infectious Diseases
Director, Molecular Virology and Gene Expression Core
Center for AIDS Research
Case Western Reserve University
TEL: (216) 844-7767
FAX: (216) 844-1409

Web Page

Research Interest(s)
Molecular virology and viral immunology of several important human pathogens, namely human immunodeficiency virus (HIV-1), smallpox, SARS coronavirus and West Nile virus. The primary activity of the lab is to develop and/or improve vaccines against HIV-1, smallpox and SARS-CoV. The laboratory uses molecular biology techniques to generate novel vaccine candidates and evaluate their immunogenicity in laboratory animals. The laboratory is also involved in characterizing structural-functional properties of viral proteins that allow viruses to enter cells as well as assessing host immune responses that are mounted against those proteins.

Selected Publications
Han, D. P., H. G. Kim, Y. B. Kim, L. L. M. Poon, M. W. Cho (2004). Development of a safe neutralization assay for SARS-CoV and Characterization of S glycoprotein. Virology. 326: 140-149.

Kim, Y. B., D. P. Han, C. Cao, M.W. Cho (2003). Immunogenicity and ability of variable loop-deleted human immunodeficiency virus type 1 envelope glycoproteins to elicit neutralizing antibodies. Virology 305: 124-137

Cho, M. W. (2003). Subunit protein vaccines: Theoretical and practical considerations for HIV-1. Curr. Mol. Med. 3:243-263. (Review).

James F. Clapp III, M.D.
Emeritus Professor of Reproductive Biology
Case Western Reserve University
TEL: (216) 778-4818
FAX: (216) 778-1574


Research Interest(s)
Currently Dr. Clapp is involved in studies examining the effects of supine exercise during pregnancy on uterine blood flow and fetal well-being, the effects of exercise during pregnancy on immune function, and the effects of exercise during pregnancy on long-term growth and development of the offspring. Other ongoing studies involve the effects of diet during pregnancy on maternal metabolism and fetal growth and the fetal effects of cord entanglement.

Selected Publications
CLAPP JF, Little KD, Widness JA. Effect of maternal exercise and feto-placental growth on serum erythropoietin. Am J Obstet Gynecol 188:1021-1025, 2003.

CLAPP JF, Schmidt S, Petry K, Lopez B.. The effects of maternal exercise on fetal oxygenation and feto-placental growth. EJOGRB 110: S80-S85, 2003.

CLAPP JF, Stepanchak W, Hashimoto K, EHRENBERG H, Lopez B. The natural history of antenatal nuchal cords. Am J Obstet Gynecol 189:488-493, 2003.

Clapp JF, Kett A, Olariu N, Omoniyi AT, Wu D, Kim H, Szeto HH. Cardiovascular and metabolic responses to two receptor selective opioid agonists in pregnant sheep. Am J Obstet Gynecol 1998;178:397-401.

Kett A, Omonyi A, Kim H, Olariu N, Wu D, Szeto HH, Clapp JF. Baroreceptor-mediated bradycardia but not tachycardia is blunted by intravenous m-opioid agonists. Am J Obstet Gynecol 1998;178:950-955.

Alfred F. Connors, Jr., M.D.
Chair, Department of Medicine
Case Western Reserve University at
MetroHealth Medicial Center
Charles H. Rammelkamp Jr. Professor of Medicine
Case Western Reserve University School of Medicine
TEL: (216) 778-8266
FAX: (216) 778-5823

Biosketch
Curriculum Vitae

Research Interest(s)
Evaluation & measurement of patient outcomes, determining effectiveness of therapy, devices & processes of care, medical decision making, management of the seriously ill, and cost-effectiveness analysis.

Selected Publications
Stukenborg GJ, Wagner DP, Connors AF Jr. A comparison of two comorbidity measures with and without information from prior hospitalizations. Medical Care, 2001;39;727-739. Go to Publication

Arseneau KO, Cohn SM, Comminelli F, Connors AF Jr. Cost-utility of initial medical management for Crohn’s disease perianal fistulae. Gastroenterology 2001;120:1640-1656. Go to Publication

Rose JH. O`Toole EE. Dawson NV. Thomas C. Connors AF Jr. Wenger N. Phillips RS. Hamel MB. Reding DT. Cohen HJ. Lynn J. Generalists and oncologists show similar care practices and outcomes for hospitalized late-stage cancer patients. Medical Care. 2000;38:1103-1118. Go to Publication

Johnston KC, Connors AF Jr, Wagner DP, Haley EC Jr. Risk adjustment effect in stroke clinical trials. Stroke. 2004;35:43-45 Go to Publication

Stukenborg GJ, Wagner DP, Harrell FE, Oliver MN, Kilbridge K, Lyman J, Einbinder J, Connors AF. Hospital discharge abstract data on comorbidity improved the prediction of death among patients hospitalized with aspiration pneumonia. J Clin Epidemiol 2004; 57: 522-532. Go to Publication

Otto Costantini, M.D.
Assistant Professor of Medicine
Director, Arrhythmia Prevention Center
Director, Clinical Trials Unit
TEL: (216) 778-8765
FAX: (216) 778-392


Research Interest(s)
Prediction and prevention of sudden cardiac death. Risk stratification of congestive heart failure patients for ventricular arrhythmias. Outcomes and quality of life of patients with CHF and ventricular arrhythmias. Triggers of ventricular tacharrhythmias in patients at risk.

Selected Publications
Costantini O, Rosenbaum DS. Can sudden cardiac death be predicted from the T wave of the ECG? PACE 2000;23:14071416.

Quan KJ, Lee JH, Costanini et al. Favorable results of ICD implantation in patients older than 70. Ann Thorac Surg 1997;64:1713-1717.

Costantini O, Huck K, Carlson MD et al. Impact of a guideline based disease management team on outcomes of hospitalized patients with congestive heart failure. Arch Intern Med 2001;161:177-185

Graham Creasey, MD, FRCSEd
Associate Professor
Dept of Physical Medicine & Rehabilitation
Case Western Reserve University
Attending Physician
Dept of Physical Medicine & Rehabilitation
MetroHealth and VA Medical Centers
Principal Investigator
Functional Electrical Stimulation Center
TEL: (216) 778-5807, (216) 778-3472
FAX: (216) 778-1653


Curriculum Vitae
Functional Electrical Stimulation Center
PM&R, MetroHealth Medical Center

Research Interest(s)
Dr. Creasey studies the use of electrical stimulation to restore bladder, bowel, and sexual function following spinal cord injury, and the effects of these interventions on quality of life and costs.

Selected Publications
Lee YH, Creasey GH. Self-controlled dorsal penile nerve stimulation to inhibit bladder hyperreflexia in incomplete spinal cord injury: a case report. Arch Phys Med Rehabil. 2002 Feb;83(2):273-277. Go to Publication

Creasey GH, Dahlberg JE. Economic consequences of an implanted neuroprosthesis for bladder and bowel management. Arch Phys Med Rehabil. 2001 Nov;82(11):1520-1525. Go to Publication

Creasey GH, Grill JH, Korsten M, Betz R, Anderson R, Walter J. An implantable neuroprosthesis for restoring bladder and bowel control to patients with spinal cord injuries: a multicenter trial. Arch Phys Med Rehabil. 2001 Nov;82(11):1512-1519. Go to Publication

Gustafson KJ, Creasey GH & Grill WM. A catheter-based method to activate urethral sensory nerve fibers. Journal of Urology 170(1):126-129, 2003 Go to Publication

Creasey GH, Kilgore KL, Brown-Triolo DL, Dahlberg JE, Peckham PH, Keith MW. Reduction of costs of disability using neuroprostheses.Assist Technol. 2000;12(1):67-75. Go to Publication

Barbara Cromer, M.D.
Professor, Department of Pediatrics
Director, Adolescent Medicine, Department of Pediatrics
MetroHealth Medical Center
Case Western Reserve University
TEL: (216) 778-2643

Curriculum Vitae

Research Interest(s)
Dr. Cromer`s research currently is on different hormonal forms of birth control and bone density. Her staff is comparing bone thickness in adolescent girls who select either Depo-Provera (an injection ) or the birth control pill. They will also compare bone density of girls not using birth control. Preliminary findings suggest that bones may thin with the use of Depo-Provera.

Selected Publications
Cromer BA, Stager MM. Research articles published in Journal of Adolescent Health: a two-decade comparison. J Adolesc Health. 2000 Nov;27(5):306-313.

Stager MM, Cromer BA. Management of clinical side effects of DMPA. J Pediatr Adolesc Gynecol. 2000 Aug;13(3):147-149.

Valencia LS, Cromer BA. Sexual activity and other high-risk behaviors in adolescents with chronic illness: a review. J Pediatr Adolesc Gynecol. 2000 May;13(2):53-64.

Cromer BA, Schoenbachler R, Vesha K, Davis J, Wescher J: Compliance in adolescents using different forms of hormonal contraception. Sexological Review 1998; 5:129-42.

Cromer BA, Berg-Kelly K, van Groningen JP, Seimer BS, Ruusavaara L. Depot medroxyprogesterone acetate (Depo-Provera) and levonorgestrel (Norplant) use in adolescents among clinicians in Northern Europe and the United States. J Adolesc Health 1998;22:74-80.

Pamela B. Davis, M.D., Ph.D.
Professor of Pediatrics, Physiology & Biophysics,
and Molecular Biology & Microbiology
Department of Medicine,
Veterans Administration Medical Center
Arline H. and Curtis F. Garvin, M.D., Research Professor
Senior Associate Dean for Research
Case Western Reserve University
TEL: (216) 368-4370
FAX: (216) 368-4223

Web Page
Curriculum Vitae

Research Interest(s)
The goal of our laboratory is to understand the pathophysiology of cystic fibrosis (CF), a common fatal genetic disease, and to ultimately to ameliorate or cure it. CF is caused by defects in a gene that encodes a chloride channel, CFTR, but the patients succumb to pulmonary infection and inflammation. One line of work in our lab investigates how dysfunction of CFTR leads to infection and particularly the excess inflammatory response that characterizes the CF lung disease. In cell and animal models, CF cells and CF mice have excessive cytokine responses to bacterial stimulation, which contributes to lung damage. We study the mechanism of this excessive response and how to prevent it without impairing host defenses. We have shown previously that high dose ibuprofen ameliorates the excessive inflammation, and it is our current working hypothesis that the mechanism of this effect is by binding to PPAR *, a nuclear receptor which can interact with the pro inflammatory transcription factor NF *B, in reciprocal fashion. Ultimately, we will build upon our findings in cell and animal models for design of a clinical trial.

A second line of work is to devise means of delivering the corrective CFTR gene to the airways of patients with CF. We have constructed DNA nanoparticles that consist of plasmid DNA compacted with polylysine and stabilized with polyethylene glycol, in which the smallest diameter is less than that of the nuclear pore. This small size allows nuclear access in nondividing cells. These nanoparticles can transfect airway epithelium in vivo in CF mice to a sufficient extent to correct not only the CF chloride transport defect but also some of its downstream consequences. In addition, these nanoparticles seem to be quite nontoxic, and they can be dosed repeatedly without decrement in effect. A single dose Phase I clinical trial in the nose of human patients with CF was completed, with the result that 8 of 12 subjects had improvement in chloride transport, with no adverse effects attributable to the drug. Current work is investigating potential improvements in the DNA nanoparticles (including targeting and improvement of the plasmid construct), aerosolization of the particles for pulmonary treatment, and extension of the molecular targets to delivery of siRNA directed against respiratory viruses.

Selected Publications
Ziady, AG, Gedeon, CR. Miller, T, Quan, W. Payne JM, Hyatt SL, Fink TL, Muhammed O, Oette S, Kowalczyk,T. Pasumarthy M, Moen, RC, Cooper MC, and Davis, P.B. Transfection of Airway Epithelium by Stable PEGylated Poly L lysine DNA Nanoparticles In Vivo, Mol Ther. 8(6):936 47, 2003.

Ziady AG, Gideon CR, Muhammad O, Stillwell V, Oette SM, Fink TL, Quan W, Kowalczyk TH, Hyatt SL, Peischl A, Seng JE, Moen RC, Cooper MJ, and Davis PB. Minimal Toxicity of Stabilized compacted DNA nanoparticles in the murine lung. Mol Ther. 8(6):948 56, 2003.

van Heeckeren AM Schluchter, MD Davis, PB Role of Cftr Genotype in the Response to Chronic Pseudomonas aeruginosa Lung Infection in Mice Am J. Physiology:Lung Cell and Molecular Physiology 2004 ;287(5):L944 52.

Neal V. Dawson, M.D.
Professor of Medicine, Epidemiology and Biostatistics
MetroHealth Medical Center Staff Since 1982
Center for Health Care Research and Policy
TEL: (216) 778-3901
FAX: (216) 778-3945


Biosketch
Curriculum Vitae

Research Interest(s)
Dr. Dawson is a specialist in general internal medicine and works in the MetroHealth Primary Care Internal Medicine Clinic (Firms). He has published on the use of Firms for research, especially in health services. He recently completed a Firm trial on alcohol screening and management in a primary care setting. He is currently looking at predictors of alcohol use among nonaddicted Hepatitis C patients. In addition he has considerable experience in the conduct of large studies and in multvariable analyses of large databases.

Selected Publications
Murray PK, Love TE, Dawson NV, Thomas CL, Cebul RD. Rehabilitation services following the implementation of the nursing home prospective payment system: Differences related to patient and nursing home characteristics. Medical Care 2005; 43:1109 15.

Bailit JL, Love TE, Dawson NV. Quality of obstetric care and risk-adjusted primary cesarean rates. Am J Ob Gyn 2006;194:402-7.

Bailit JL, Schulkin J, Dawson NV. Risk-adjusted cesarean rates: What risk factors for cesarean delivery are important to practicing obstetricians? Am J Reprod Med 2006; (in press).

Lindstrom HA, Smyth KA, Sami SA, Dawson NV, Patterson MB, Bohinc JH, Post SG, Barber MJ, Ollerton S, Singer M, Whitehouse PJ. Medication use to treat memory loss in dementia: perspectives of people with dementia and their caregivers. Dementia 2006;5(1):27-50.

Stoller EP, Hund AJ, Webster NJ, Blixen CE, Perzynski AT, McCormick RA, Kanuch SW, Dawson NV. Alcohol consumption within the context of hepatitis C: a qualitative study of non-problematic drinkers. Alcohol and Alcoholism 2006; 41(5):546-552.

Dorr G. Dearborn, Ph.D., M.D.
Professor of Pediatrics
Mary Ann Swetland Professor of
Environmental Health Sciences
Case Western Reserve University


Research Interest(s)
Primary Research Interest-
Extensive Mold Exposure: Health Effects for Infants and Children
Acute Pulmonary Hemorrhage in Infants:
Over the past ten years, there have been 38 infants with acute pulmonary hemorrhage cared for at our pediatric hospital; five infants have died. The initial case-control study of the first 10 infants, led by the CDC, found an association with exposure to moldy home environments. Additional experience supports the association since 88% of the total 38 infants have come from water-damaged home environments containing Stachybotrys chartarum and other fungi. Removing these infants from their original home environments resulted in a 17-fold decrease in re-bleeding (Dearborn, et al., Pediatrics, 110:627,2002). The association is further supported by infant animal studies. Additional factors of environmental tobacco smoke and bacterial endotoxin are being considered.

Related Research Projects-
1. Continued collection and analysis of acute respiratory tract samples from infants presenting with acute pulmonary hemorrhage.
2. Further development of quantitative PCR and immunological biomarkers to document acute fungal exposure in infants and children.
3. Extension of our acute fungal exposure model in infant rats to a more chronic, low level exposure.
4. Kinetics of mycotoxin and proteinase release from fungal spores.

Mold-related Health Effects in Children:
A. Children of families who have left their homes because of adverse health effects apparently due to extensive mold contamination have been seen for clinical and psychometric evaluation. Initial, uncontrolled observations note that most laboratory tests including IgG fungal serologies are seldom abnormal. Symptom profiles obtained by retrospective questionnaire reflect significant reductions of most general health and respiratory symptoms after the children are out of the moldy environments. Children exposed prior to six years of age appear to have an increased incidence of language deficits.

Related Research Projects-
1. Case-control study of infants and siblings of mold exposure and possible neurotoxicity as seen by Visual Contrast Sensitivity and language psychometric evaluation.

B. Children living in damp, moldy home environments are at-risk of developing respiratory illness, both acutely and longer term. In a recently completed study supported by US HUD and US EPA (Cuyahoga County Urban Mold and Moisture Project, UMMP), explored the relationship between mold, moisture, asthma triggers and the respiratory health of children living in inner city neighborhoods throughout Greater Cleveland. Clinical and environmental assessments before and after targeted remediation found significant improvement in moderately severe asthmatic children compared to randomized controls whose homes were not remediated (decrease in symptom score (Am Acad Ped Asthma Health Survey) p<0.006 and symptom days p<0.003). The home intervention group also had a lower rate of exacerbations requiring hospitalization or an emergency room visit compared to control asthmatics (1/29 vs. 11/33, respectively, p=.003). Environmental assessments found a significant decrease in the visual mold (p=0.0035) and the ratio of indoor/outdoor mold species (p=0.049) in remediated versus control homes. The large data base generated by the extensive semi-quantitative culturing of fungi and the quantitative PCR measurements of 33 fungal species continues to be analyzed. While the significance of the UMMP study is limited due to the small number of families and homes investigated, the observed clinical improvements are very encouraging and underline the need to expand on these observations in larger studies in cooperation with other pulmonary centers.

Selected Publications
Dearborn, DG, Smith, PG, Dahms, BB, Allan, TM, Sorenson, WG, Montana, E, Etzel, RA, Clinical profile of thirty infants with acute pulmonary hemorrhage in Cleveland. Pediatrics, 110:627-637, 2002.

Yike, I, and Dearborn, D.G. Pulmonary effects of Stachybotrys chartarum in animal studies. In: Advances in Applied Microbiology, Sick Building Syndrome, D. Strauss (ed), Elsevier Inc, 2004, p.241-273.

Vesper, SJ, Varma, M, Wymer, LJ, Dearborn, DG, Sobolewski, J, Haugland, RA. Quantitative polymerase chain reaction analysis of fungi in dust from homes of infants who developed idiopathic pulmonary hemorrhaging, J Occup Environ Med, 46:596-601, 2004

Adrienne T. Dennis, Ph.D.
Staff Scientist
Rammelkamp Center for Education & Research
MetroHealth Medical Center
TEL: (216) 778-8667
FAX: (216) 778-8282


Research Interest(s)
Molecular mechanisms involved in the processing of the cardiac potassium channel HERG within the cell and how this changes in hereditary or acquired (drug-induced) long QT syndrome (LQT2).

Selected Publications
Ficker E., Kuryshev Y.A., Dennis A.T., Obejero-Paz C., Wang L., Hawryluk P., Wible B.A., Brown A.M. Mechanisms of Arsenic-Induced Prolongation of Cardiac Repolarization. Mol. Pharmacol. 66:33-44, 2004. Go to Publication

Ficker E., Dennis A.T., Wang L., Brown A.M. Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG. Circ. Res. 92:e87-100, 2003. Go to Publication

Ficker E, Dennis AT, Obejero-Paz CA, Castaldo P, Taglialatela M, Brown AM. Retention in the endoplasmic reticulum as a mechanism of dominant-negative current suppression in human long QT syndrome. J. Mol. Cell. Cardiol. 2000;32:2327-2337. Go to Publication

Ficker E, Thomas D, Viswanathan PC, Dennis AT, Priori SG, Napolitano C, Memmi M, Wible B A, Kaufman ES, Iyengar S, Schwartz PJ, Rudy Y, Brown AM. Novel characteristics of a misprocessed mutant HERG channel linked to hereditary long QT syndrome. Am. J. Physiol. 2000;279:H1748-H1756 Go to Publication

Isabelle Deschênes, Ph.D.
Assistant Professor of Medicine
Case Western Reserve University
Heart & Vascular Research Center
MetroHealth Medical Center
TEL: (216) 778-5166
FAX: (216) 778-1261

Curriculum Vitae

Research Interest(s)
Potentially lethal arrhythmias in rare inherited syndromes (idiopathic ventricular fibrillation) and more common, acquired heart diseases (cardiac hypertrophy and failure) have been associated with an imbalance of depolarizing (Na current) and repolarizing (Ito) current early in the ventricular action potential and a down regulation of Ito respectively. Our previous work demonstrated that cardiac Ito and INa form a macromolecular complex. Delineation of the molecular basis of this macromolecular complex formed by Ito and INa is essential for an accurate understanding of cardiac ventricular depolarization and repolarization and its derangements that are associated with lethal ventricular arrhythmias.

In this project we combine the use of gene silencing (RNA interference) and Fluorescence Resonance Energy Transfer (FRET) to electrophysiological recordings to elucidate the molecular basis, structure and function of this macromolecular complex formed between channel subunits that comprise voltage-dependent Na channels and the transient outward K current Ito. This work will have broad appeal and important implications for cellular electrophysiology of cardiac muscle and its derangements in both congenital and acquired diseases associated with potentially lethal cardiac arrhythmias.

Anthony DiMarco, M.D.
Professor
Functional Electrical Stimulation Center
TEL: (216) 778-3906
FAX: (216) 778-4321



Research Interest(s)
The purpose of Dr. DiMarco`s studies is to restore respiratory muscle function in patients with spinal cord injury. FES is developing systems for electrical activation of the inspiratory muscles to maintain full-time ventilatory support in patients with ventilator-dependent tetraplegia and electrical activation of the expiratory muscles to provide an effective cough mechanism in patients with expiratory muscles paralysis.

Selected Publications
DiMarco AF. Neural prostheses in the respiratory system. J Rehabil Res Dev. 2001 Nov-Dec;38(6):601-607.

DiMarco AF, Romaniuk JR, Supinski G, Kowalski KE. Effects of lung volume on parasternal pressure-generating capacity in dogs. Exp Physiol. 2000 May;85(3):331-337.

Stofan DA, Callahan LA, DiMarco AF, Nethery DE, Supinski GS. Modulation of release of reactive oxygen species by the contracting diaphragm. Am J Respir Crit Care Med. 2000 Mar;161(3 Pt 1):891-898.

Clark W. Distelhorst, M.D.
Professor of Medicine
Professor of Pharmacology
Charles S. Britton II Professor of Hematology/Oncology
Case Western Reserve University
TEL: (216) 368-4546
FAX: (216) 368-8919


Research Interest(s)
Research in the laboratory of Dr. Clark Distelhorst has two fundamental goals. One is to understand how glucocorticosteroid hormones (dexamethasone, prednisone) induce apoptosis in lymphocytes and the other is to understand how Bcl-2 inhibits apoptosis, emphasizing the role of Bcl-2 on the endoplasmic reticulum. Because glucocorticosteroid hormones induce apoptosis in young lymphocytes, glucocorticoid hormones have an important role in the treatment of a wide variety of lymphoid cancers. Understanding the mechanism of apoptosis induction by glucocorticoids will enable us to develop novel therapies and overcome resistance to glucocorticoid-induced apoptosis, while providing novel insight into a fundamentally important mechanism of apoptosis induction. Conversely, the primary action of Bcl-2 is to inhibit apoptosis. In this way Bcl-2 promotes cancer cell survival and inhibits cell killing by chemotherapeutic agents. The laboratory has many accomplishments. Using oligonucleotide microarrays, we have profiled the gene changes induced by dexamethasone in lymphoma cell lines and in primary murine thymocytes. This profile has uncovered many interesting genes and has set the stage for a number of projects in our lab. For example, we have recently discovered that the proapoptotic BH3-only protein Bim is induced by dexamethasone in normal primary thymocytes and in lymphoma cells. Thus, Bim is a glucocorticoid-induced “death gene”. As revealed by our microarray findings, a number of other interesting genes are induced by dexamethasone that may contribute to the life-death decision of cells treated with dexamethasone. On another front, our laboratory was the first, over ten years ago, to indicate that Bcl-2 works at the level of the endoplasmic reticulum to regulate calcium signals involved in mediating apoptosis.

Determining the effect of Bcl-2 on calcium signals is one of the highest priorities in our laboratory today. In addition, we are interested in the role of ER-localized Bcl-2 in regulating protein-protein interactions with other family members. Recently we have employed targeting sequences to direct Bcl-2 to either ER or mitochondria. Paradoxically we discovered that Bcl-2 targeted to the outer mitochondrial membrane induces apoptosis, whereas Bcl-2 targeted selectively to the ER is antiapoptotic.

Selected Publications
Thomenius MJ, Wang NS, Reineks EZ, Wang Z, and Distelhorst CW. Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3 only proteins. J. Biol. Chem. 278:6243-6250, 2003

Wang Z, Malone MH, He H, McColl KS, Distelhorst CW. Microarray analysis uncovers the induction of the pro-apoptotic BH3-only protein Bim in multiple models of glucocorticoid induced apoptosis. J. Biol. Chem. 278:23861-23867, 2003

Wang Z, Malone MH, Thomenius MJ, Zhong F, Xu F, Distelhorst CW. Dexamethasone-induced gene 2 (dig2) is a novel prosurvival stress gene induced rapidly by diverse apoptotic signals. J Biol Chem 278:27053-27058, 2003

Chen R, Valencia I, Zhong F, McColl KS, Roderick HL, Bootman MD, Berridge MJ, Conway SJ, Holmes AB, Mignery GA, Velez P, Distelhorst CW. Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate. J Cell Biol 166:193-203, 2004

Malone M, Wang Z, Distelhorst CW. The glucocorticoid-induced gene tdag8 encodes a pro-apoptotic G protein-coupled receptor whose activation promotes glucocorticoid-induced apoptosis. J Biol Chem 279:52850-52859, 2004

Kevin Donahue, M.D.
Associate Professor of Medicine
Case Western Reserve University
TEL: (216) 778-5998
FAX: (216) 778-1261

Curriculum Vitae

Selected Publications
Donahue JK, Bauer A, Kikuchi K, Sasano T. Modification of cellular communication by gene transfer. Annals of the New York Acad Sci 1047:157-165 2005.

Donahue JK, Kikuchi K, Sasano T. Gene Therapy for Cardiac Arrhythmias. Trends in Cardiovascular Med 15:219-224 2005.

Donahue JK. Gene Therapy for Cardiac Arrhythmias. Annals of the New York Acad Sci 1015:332-338 2004.

Douglas Einstadter, M.D, M.P.H.
Professor of Medicine, Epidemiology and Biostatistics
Member, Center for Health Care Research and Policy
Staff Physician, Department of Medicine
TEL: (216) 778-3901
FAX: (216) 778-3945

Biosketch
Curriculum Vitae

Research Interest(s)
Use of large databases in health services research; Application of Geographic Information Systems (GIS) to health services research; Use of informatics to improve quality of care.

Selected Publications
Baker DW, Einstadter D, Husak SS, and Cebul RD. Trends in postdischarge mortality and readmissions: has length of stay declined too far? Arch Intern Med. 2004 Mar 8;164(5):538-44

Baker DW, Einstadter D, Thomas C, Cebul RD Mortality trends for 23,505 Medicare patients hospitalized with heart failure in Northeast Ohio, 1991 to 1997. Am Heart J. 2003 Aug;146(2):258-64.

Yuan Z, Dawson N, Cooper GS, Einstadter D, Cebul R, Rimm AA. Effect of Alcohol-related Disease on Hip Fracture and Mortality: A Retrospective Cohort Study of 876,337 Hospitalized Medicare Beneficiaries. Am J Public Health 2001;91:1089-1093.

Yuan Z, Cooper GS, Einstadter D, Cebul RD, Rimm AA. The Association Between Hospital Type and Mortality and Length of Stay. Medical Care 2000;38:231-245.

Hoffman RM, Einstadter D, Kroenke K. Evaluating Dizziness. Am J. Med. 1999;107:468-478.

Ashraf El-Meanawy, M.D., Ph.D.
Assistant Professor
Department of Medicine, MetroHealth Medical Center
Case Western Reserve University
Renal Research Center
TEL: (216) 778-1087
FAX: (216) 778-4321



Research Interest(s)
Dr. El-Meanawy investigates the genetics of end stage renal disease (ESRD). He applies molecular genetics techniques to identify genes that are involved in the development or conferring susceptibility to end stage renal disease. This laboratory uses a genetically susceptible animal model that develops spontaneous progressive renal failure. Dissecting the gene expression patterns in the diseased and comparing that to the healthy control animals should allow the lab staff to identify genes involved in the development of ESRD. Further study of these genes can lead to development of novel diagnostic and therapeutic modalities.

Selected Publications
Schelling JR, El-Meanawy MA, Barathan S, Dodig T, Iyengar SK, Sedor JR. Generation of kidney transcriptomes using serial analysis of gene expression. Exp Nephrol. 2002;10(2):82-92.

El-Meanawy MA, Schelling JR, Pozuelo F, Churpek MM, Ficker EK, Iyengar S, Sedor JR. Use of serial analysis of gene expression to generate kidney expression libraries. Am J Physiol Renal Physiol. 2000 Aug;279(2):F383-392

Robert B. Elson, M.D., M.S.
Senior Informatics Researcher
Center for Health Care Research & Policy
MetroHealth Medical Center
TEL: (216) 778-3916
FAX: (216) 778-3945

Curriculum Vitae

Selected Publications
Elson, R.B. Outpatient Prescription History in the Hospital: The Opportunity and Challenge of RxHub MEDS. Part I: Background and Benefits. RxHub White Paper. February 2004.

Teich, J., Hale, P., Elson, R., Frisse, M., Glaser, J. Electronic Prescribing: Toward Maximum Value and Rapid Adoption. eHealth Initiative. Washington, D.C., 4/14/04 .

Elson, R.B. Web-based systems rejuvenate physician-patient communications. Group Practice Journal, May 2001:43-45.

Eckhard Ficker, Ph.D.
Jr. Staff Scientist
TEL: (216) 778-8977
FAX: (216) 778-8282

Curriculum Vitae

Research Interest(s)
Cellular pathophysiology of LQT2/HERG K+ channels

Selected Publications
FICKER, E., DENNIS, A.T., OBEJERO-PAZ, C.A., CASTALDO, P., TAGLIALATELA, M., BROWN, A.M. Retention in the endoplasmic reticulum as a mechanism of dominant-negative current suppression in human long QT syndrome. J. Mol. Cell. Cardiol., 32, 2327-2337, 2000

FICKER, E., JAROLIMEK, W., KIEHN, J., BAUMANN, A., BROWN, A.M. Molecular determinants of dofetilide block of HERG potassium channels. Circ. Res., 82, 386-395, 1998

FICKER, E., TAGLIALATELA, M., WIBLE, B.A., HENLEY, C.M., BROWN, A.M. Spermine and Spermidine as gating molecules for inward rectifier K+ channels. Science, 266, 1068-1072, 1994

Robert S. Finkelhor, M.D.
Director, Non-Invasive Cardiology
Associate Professor
Case Western Reserve University
TEL: (216) 778-5270


Research Interest(s)
General Cardiology,
Non-Invasive Cardiology,
Cardiac Imaging

James Finley, M.D., Ph.D.
Physician, Pulmonary & Critical Care Medicine
MetroHealth Medical Center
Associate Professor
Case Western Reserve University
TEL: (216) 778-2927
FAX: (216) 778-3240


Research Interest(s)
COPD
Critical Care Medicine

Sharon Groh-Wargo, PhD, RD, LD
Assistant Professor
Departments of Pediatrics and Nutrition
Case Western Reserve University
Neonatal Nutritionist
Department of Pediatrics
MetroHealth Medical Center
TEL: (216) 778-5902, (216) 778-5909
FAX: (216) 778-3252


Research Interest(s)
Neonatal nutrition, growth and body composition

Selected Publications
Ryan AS, Montalto MB, Groh-Wargo S, Mimouni F, Sentipal-Walerius J, Doyle J, Siegman JS, Thomas AJ. Effect of DHA-containing formula on growth of preterm infants to 59 weeks postmenstrual age. Am J Hum Biol 11: 457-467, 1999.

Groh-Wargo S, Cox JH, Thompson M (eds). Nutritional Care for High Risk Newborns, 3rd Revised Edition. Precept Press, Chicago, 2000.

O`Connor DL, Hall R, Adamkin D, Auestad N, Castillo M, Connor WE, Connor SL, Fitzgerald K, Groh-Wargo S, et al. Growth and development in preterm infants fed long-chain polyunsaturated fatty acids: A prospective randomized control trial. Pediatrics 108: 359-371, 2001.

O`Connor DL, Jacobs J, Hall R, Adamkin D, et al, Groh-Wargo S, et al. Growth and development of premature infants fed predominantly human milk, predominantly premature infant formula, or a combination of human milk and premature formula. J Pediatr Gastroenterol Nutr 37:437-46,2003.

Diyana R. Gunawardena, M.D.
Geriatrics Physician
Assistant Professor
Case Western Reserve University
TEL: (216) 778-2431


Research Interest(s)
Heart Failure, Geriatrics

Kenneth J. Gustafson, Ph.D.
Staff Scientist, Dept. of Orthopaedics
MetroHealth Medical Center
Department of Biomedical Engineering
Neural Engineering Center
Case Western Reserve University
TEL: (216) 778-3801


Research Interest(s)
Research interests focus on understanding the systems-level neurophysiology and neural control of pelvic functions, and using this information to design and develop neural prostheses that interface with native spinal neural circuitry and restore physiologic function. Bladder dysfunction can have a devastating clinical impact. Therefore my efforts include developmental and pre-clinical studies to translate research advances into clinical implementation at the earliest opportunity. Current projects in both animal models and individuals with neural dysfunction include peripheral activation of spinal circuits to activate and inhibit bladder function, development of an implanted neural prosthesis able to selectively record and stimulate neural pathways and restore bladder function (a bladder pacemaker), neural recording of organ activity as a control source for closed-loop neural prostheses, commercial activities to translate research discoveries into clinical practice, combining myoplasty and neuromuscular stimulation to harness skeletal muscle power for cardiac assist and rehabilitation applications, and exploring neural anatomy to improve peripheral nerve electrode design.

Selected Publications
Gustafson KJ, Creasey GH and Grill WM. A urethral afferent mediated excitatory bladder reflex exists in humans. Neuroscience Letters, 360(1-2): 9-12, 2004.

Gustafson KJ, Creasey GH and Grill WM. A Catheter Based Method to Activate Urethral Sensory Nerve Fibers. Journal of Urology, 170(1):126-129, 2003.

Gustafson, KJ, JD Sweeney, J Gibney, LA Fiebig-Mathine. Skeletal muscle ventricle pressure-volume properties conform to dynamic and static conditioning. Annals of Thoracic Surgery. 76(3):828-835, 2003.

Subrata Haldar, Ph.D.
Staff Scientist, Research, MetroHealth Medical Center
Associate Professor, Dept. of Pharmacology, Case Western Reserve University
Member, Cell Death & Proliferation Program, Case Comprehensive Cancer Center
TEL: (216) 778-1167, (216) 778-2237
FAX: (216) 778-4321



Research Interest(s)
The long-term goal of Dr. Haldar`s research is apoptosis (cell suicide) inducing therapy that can be targeted for prevention of cancer. Cancer cells have growth advantage and it is becoming clear that they also have a death advantage. In tumors, cells that have adapted the ability to escape apoptosis (high resistance to cancer therapy) contribute to the net accumulation of tumor mass.

Selected Publications
Basu A and Haldar, S (2003) Identification of a novel bcl-xL phosphorylation site regulating the sensitivity of Taxol or 2-Methoxyestradiol induced apoptosis. 538:41-47.

Basu A, Das M, Qanungo S, Fax X-U, Dubois G and Haldar S (2002)Proteasomal degradation of human peptidyl prolyl isomerase pin 1-pointing phospho Bvl2 towards dephosphorylation. Neoplasia 4:218-227.

Haldar S, Basu A and Croce CM (1998) Serine-70 is one of the critical site necessary for drug induced Bcl2 phosphorylation in cancer cells. Cancer Res 58:1609-1615.

Qanungo S, Basu A, Das M and Haldar S (2002) 2-methoxyestradiol elicits mitochondria dependent apoptotic signaling in pancreatic cancer cells. Oncogene 21:4149-4157.

Haldar S, Jena, N and Croce CM (1995) Inactivation of Bcl2 by phosphorylation. Proc Natl Acad Sci USA 92: 4507-4511.

Joseph Hanna, M.D.
Director, Department of Neurology
MetroHealth Medical Center
Assistant Professor
Case Western Reserve University
TEL: (216) 778-3922


Research Interest(s)
GAINS Stroke Study
Citicoline Stroke Study
Vitamin Intervention for Stroke Prevention

Richard W. Hanson, Ph.D.
Professor of Biochemistry
Case Western Reserve University
Center for Metabolism and Nutrition
MetroHealth Medical Center
TEL: (216) 368-5302
FAX: (216) 368-4544

Web Page

Research Interest(s)
My research centers on three major themes: (1) a study of the factors involved in regulating the expression of the gene encoding the gluconeogenic enzyme P-enolpyruvate carboxykinase (PEPCK), (2) the metabolic impact of ablating or over expressing genes in target tissues of animals, and (3) the introduction of metabolic genes interest into the liver and related tissues to alleviate metabolic diseases.

Selected Publications
Perales, J.C., Grossman, G., Ferkol, T., Liu, G., Harpst, J., Oda, H. and Hanson, R.W. Biochemical and functional characterization of DNA complexes capable of targeting genes to the liver via the asialoglycoprotein receptor. J. Biol. Chem. 272, 7398-7407 (1997).

Savon, S.R., Hakimi, P., Crawford, D.R., Klemm, D.J., Gurney, A.L. and Hanson, R.A. The promoter regulatory regions of the genes for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) from the chicken and the rat have different species-specific roles in gluconeogenesis. J. Nutr. 127, 276-285 (1997).

Hanson, R.W.and Reshef, L. Regulation of P-enolpyruvate carboxykinase (GTP) gene expression. Annual Review of Biochemistry 66, (1997).

Michael Harrington, M.D.
Director of Palliative Care Clinical Services
Staff Physician, Division of General Medicine
Staff Physician, Jennings Center for Older Adults
TEL: (216) 778-5048


Research Interest(s)
End-of-life care
Advance Directives
Pain Management

Sylvie Hauguel-de Mouzon, Ph.D.
Professor of Reproductive Biology
Director, Molecular Biology Laboratory
OBGYN
Schwartz Center for Metabolism and Nutriton
TEL: (216) 778-3148, (216) 778 4262
FAX: (216) 778-1574


Research Interest(s)
The primary research interest of our group is in the mechanisms that regulate the growth of the fetus in utero in normal and pathological pregnancies. Over the last 10 years, our group has investigated the interactions between the maternal compartment and the feto-placental unit and addressed the molecular mechanisms that regulate maternal-fetal exchanges. Additionally, the regulatory mechanisms related to pathological pregnancies associated with diabetes, which often results in excessive fetal growth (macrosomia) have been studied. A strong emphasis has been put on the role of leptin during pregnancy. Earlier studies have shown that the placental controls fetal growth by producing hormones that modify fetal nutrition and fat accretion. Leptin is one of these hormones synthesized in high amounts by the placenta as well as by maternal and fetal adipose tissue.

OUR group has been instrumental in showing that the placenta synthesizes as much leptin as white adipose tissue and is a primary site for leptin action. We have characterized the main molecular pathways of placental leptin signaling. We have established that fetal plasma leptin is a marker of fat accretion in the human fetus. We have shown that diabetes modifies placental transcriptome in a way that favors fetal overgrowth and obesity, inducing chronic inflammation and increasing placental lipid strorage. This research is currently being extended into mechanisms of placental and fetal programming.

Current research projects focus on 4 main areas.
1. The origin of pregnancy-induced insulin resistance through longitudinal transcriptome/proteome studies of white adipose tissue and skeletal muscle analyzed at different stages of pregnancy.
2. Transcriptional regulation of placental leptin using in vitro models of trophoblast cells.
3. Mechanisms of leptin signaling in control of gene expression using microarray analysis
4. Regulation of fetal fat accretion in relation to placental structure and function. Resolution of these issues should help establish the yet missing link between modifications of maternal environment and the development of fetal obesity. These studies have important clinical implications as they relate to our understanding of the fetal origin of adult metabolic diseases (glucose intolerance, diabetes and obesity) and ultimately its prevention.

Selected Publications
Lepercq J, Guerre-Millo M, Vidal H, Cauzac M, Timsit J, Hauguel-de Mouzon S. 2001 Prenatal leptin production: Evidence that fetal adipose tissue produces leptin. J. Clin. Endocrinol. Metab. 86, 2409-2413

Boileau P, Cauzac C, Pereira MA, Girard J and Hauguel-de Mouzon S 2001. Dissociation between insulin-mediated signaling pathways and biological effects in placental cells : role of PKB and MAPKinase phosphorylation. Endocrinology 142, 3974-3979.

Kirwan JP, Hauguel-de Mouzon S, Lepercq J, Challier JC, Huston-Presley L, Friedman JE, Kalhan SC, and Catalano PM. 2002. TNF-alpha is a primary mediator of insulin resistance in human pregnancy. Diabetes 51, 2207-2213.

Grosfeld A, André J, Hauguel-de Mouzon, Berra E, J. Pouyssegur J. Guerre-Millo M. Hypoxia-inducible factor 1 HIF-1 transactivates the human leptin gene promoter 2002. J. Biol. Chem 277, 42953-42957.

Cauzac,M, D. Czuba , Girard J and S. Hauguel-de Mouzon (2003) Transduction of leptin growth signals in placental cells is independent of JAK-STAT activation Placenta 24, 378-384.

Radaelli, T., Varastehpour, A, Catalano P and S Hauguel-de Mouzon (2003). Gestational Diabetes induces placental genes for chronic stress and inflammatory pathways Diabetes 52 : 2951-2958.

Christina S. Hirsch, M.D., Ph.D.
Assistant Professor of Medicine
Division of Infectious Diseases
Case Western Reserve University
TEL: (216) 368-0441


Research Interest(s)
Primary: T-cell apoptosis and its mediators and mechanisms; with a focus on the contribution of both T-cell and macrophage apoptosis on host immune reactivity in HIV-infected and –uninfected persons with M. tuberculosis infection/disease.Secondary: Study of the immune response during human tuberculosis; particularly cytokine responses to M. tuberculosis and its components, and the role of blood monocytes in depressed anti-tuberculous defense mechanisms.

Selected Publications
Hirsch CS, Toossi Z, Vanham G, Johnson JL, Peters P, Okwera A, Mugerwa R, Mugeyenyi P, and Ellner JJ. Apoptosis and T-cell hyporesponsiveness in pulmonary tuberculosis. J Inf Dis 179:945-53. 1999.

Hirsch CS, Toossi Z, Johnson JL, Luzze H, Ntambi E, Peters P, McHugh M, Okwera A, Joloba M, Mugeyenyi P, Mugerwa RD, Terebuh P, and Ellner JJ. Augmentation of apoptosis and IFN-production at sites of active MTB infection in human tuberculosis. J Inf Dis, 183:779-88, 2001.

Ribeiro-Rodrigues R, Resende Co T, Ribeiro F, Palaci M, Johnson JL, Sá RT, Maciel EL, Pereira Lima FL, Dettoni V, Toossi Z, Boom WH, Dietze R, Ellner JJ, and Hirsch CS. Sputum cytokine levels in patients with pulmonary tuberculosis as markers of response to treatment. Clin Diag Lab Immunol, 9:818-23, 2002

John Hodgson, M.D.
Tenured Associate Professor of Medicine
Case Western Reserve University
Director, Invasive Cardiology
MetroHealth Medical Center
TEL: (216) 778-8213
FAX: (216) 778-3927

Web Page

Research Interest(s)
Investigational drugs affecting coronary physiology, investigational devises for coronary intervention, novel pharmacologic agents for acute coronary syndrome management, intravascular ultrasound, functional measures of coronary lesion severity.

Selected Publications
Christian Mueller, MD, John McB. Hodgson, MD, Christian Schindler, PhD, Andre´ P. Perruchoud, MD, Helmut Roskamm, MD, and Heinz J. Buettner, MD. Cost-Effectiveness of Intracoronary Ultrasound for Percutaneous Coronary Interventions. Am J Cardiol 2003;91:143–147.

Frey AW, Hodgson JMcB, Müller C, Bestehorn H-P, Roskamm H. Ultrasound-guided strategy for provisional stenting with focal balloon combination catheter: Results from the Randomised Strategy for Intracoronary Ultrasound-guided PTCA and Stenting (SIPS) trial. Circulation 2000;102:2497-2502.

Hodgson JMcB, King SB, Feldman T, Cowley MJ, Klein LW, Babb JD. SCAI statement on drug-eluting stents: Practice and health care delivery implications. Catheter Cardiovasc Interv 2003;58:397-399.

Sudha Iyengar, Ph.D.
Associate Professor
Department of Epidemiology and Biostatistics
Case Western Reserve University
TEL: (216) 778-8484



Research Interest(s)
Dr. Iyengar’s laboratory is involved in mapping disease genes utilizing state-of-the-art genetic technology with the ultimate goal of developing new therapies

Selected Publications
Schelling JR, El-Meanawy MA, Barathan S, Dodig T, Iyengar SK, Sedor JR. Generation of kidney transcriptomes using serial analysis of gene expression. Exp Nephrol. 2002;10(2):82-92.

Iyengar SK, Schelling JR, Sedor JR. Approaches to understanding susceptibility to nephropathy: From genetics to genomics. Kidney Int. 2002 Jan;61 Suppl 1:61-67.

Iyengar SK, Jacobs KB, Palmer LJ. Improved evidence for linkage on 6p and 5p with retrospective pooling of data from three asthma genome screens. Genet Epidemiol. 2001;21 Suppl 1:S130-135

Nancy Johnson, M.D.
Assistant Professor of Medicine
Director, Pacemaker Services
TEL: (216) 778-2249
FAX: (216) 749-3927


Research Interest(s)
Delayed afterdepolarizations, triggered activity .

Selected Publications
Johnson NJ, Danilo P, Wit AL, Rosen MR: Characterization of initiation and termination of catecholamine-induced triggered activity in atrial fibers of the coronary sinus. Circ 74(5):1168,1986.

Johnson NJ, Marchlinski FE: Arrhythmias induced by device antitachycardia therapy due to diagnostic nonspecificity. JACC. 18(5):1418,1991.

Johnson NJ: Inconsistent response to rapid atrial rhythms in a DDD pacemaker with the fallback feature. PACE,18:1457,1995.

David C. Kaelber, M.D., PhD
Chief Resident of Internal Medicine and Pediatrics
Senior Instructor
Case Western Resrrve University
MetroHealth Medical Center
TEL: (216) 778-3680
FAX: (216) 778-1384


Web Page

Research Interest(s)
1. Use of technology in the practice and teaching of medicine.
2. Development of Med-Peds (combined Internal Medicine and Pediatrics) as a profession.
3. Asthma in children and adults.
4. Cardiac imaging.

Selected Publications
KAELBER DC. The Next Generation EKG - In Vivo Demonstration of Noninvasive Electrocardiographic Imaging During Normal Sinus Rhythm. Proceedings of the 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. San Francisco CA. 2004. (Poster)

W Cull, KAELBER DC, T Melgar, BD Kan and JK Chamberlain. Training Experiences of Combined Internal Medicine and Pediatrics Residents. Pediatric Academic Societies. 2004. (Poster)

KAELBER D, JA Nelson, LF Strauss, E West, and IA Gilbert. Decline in Asthmatics` Personal Best FEV1 is not Associated with Progressive Obstruction as Measured by Spirometry. American Thoracic Society. 2003. (Poster)

KAELBER DC, S Grove, C Dziedzina, R Cohen, D Bar-Shain and M Richard. A Pediatric PDA (Personal Digital Assistant) Program for Residents. Pediatric Academic Societies. 2003. (Poster)

KAELBER DC, SB Bierer, and JR Carter. A Web-based Clinical Curriculum on the Cardiac Exam. Academic Medicine. 76(5):448-449. 2001. (http://mediswww.cwru.edu/cardiacexam) Go to Publication

Robert C. Kalayjian, M.D.
Assistant Professor of Medicine,
Case Western Reserve University
Director,
Infectious Diseases Clinic,
MetroHealth Medical Center
TEL: (216) 778-5136


Research Interest(s)
"I am interested in clinical research that might translate to insights in pathogensis and basic disease mechanisms. I am currently the protocol chair of an Adult AIDS Clinic Trials Group, multi-center, prospective cohort study of age-differentiated HIV-infected subjects, to examine the immune and virologic basis of age-related accelerated HIV-disease progression. In this 192 wk study we are examining immune and responses to highly active antiretroviral therapy including advanced flow cytometry, responses to vaccination and skin testing, lymphoproliferative assays, and changes in markers of thymic activity.

I have received an institutional initiative grant to perform microarray analyses on some of these patients, in an effort to identify gene expression that may be associated with homeostatic proliferation of naïve T cells.

The CRSP program has allowed me to better understand issues in study design and analysis and has been a tremendous resource towards my development as a clinical researcher."

Selected Publications
Burke DG, Leonard DGB, Imperiale TF, Karaman B, Shick E, Kalayjian RC. The utility of clinical and radiographic features in the diagnosis of cytomegalovirus central nervous system disease in AIDS patients. Molec Diag 1999; 4:37-43.

Jayasekara D, Aweeka FT, Rodriguez R, Kalayjian RC, Humphreys MH, Gambertoglio JG. Antivirals in renal failure. J Acquir Immun Def Synd and Retroviruses 1999;21:384-95.

Barditch-Crovo P, Noe D, Skowran G, Lederman M, Kalayjian RC, Borum P, Buir R, Towe WB, Goldberg D, Lietman P. A phase I/II evaluation of oral L-2-oxothiazolidine-4-carboxylic acid in asymptomatic patients infected with human immunodeficiency virus. J Clin Pharmacol 1998;38:357-363.

Burke DG, Kalayjian RC, Vann VR, Medreperla SA, Shick He, Leonard DGB. Polymerase chain reactiondetection and clinical significance of varicella zoster virus in the cerebrospinal fluid from HIV-infected patients. J Infect Dis 1997;176:1080-64.

Smith MC, Austen JL, Carey JT, Emancipator SN, Herbener T, Gripshover B, Mbanefo C, Phinney M, Rahman M, Salata RA, Weigel K, Kalayjian RC. Prednisone improves renal function and proteinuria in human immunodeficiency virus-associated nephropathy. Am J Med 1996;101:41-48.

Satish C. Kalhan, M.D.
Professor, Department of Pediatrics
Director, Robert Schwartz, M.D. Center for Metabolism & Nutrition
MetroHealth Medical Center
Case Western Reserve University
TEL: (216) 778-8643



Research Interest(s)
The metabolic adaptive responses of the mother during normal pregnancy, which contribute to normal fetal growth and the transition of the normal fetus to extrauterine life, is the major focus of our group. Innovative stable isotopic tracers and gas chromatography-mass spectrometry methods are utilized in combination with indirect respiratory calorimetry in order to quantify metabolism in vivo. Perturbations in metabolism, e.g. as a consequence of maternal diabetes or intrauterine growth retardation, are being examined. Recent studies from our group have shown that, in human pregnancy, changes in maternal glucose and fat metabolism occur in parallel with the increasing fetal demands, while nitrogen conservation appears to occur early in gestation in anticipation of the fetal needs. Other studies, in collaboration, are examining the role of maternal insulin resistance on maternal protein metabolism and fetal growth, the significance and mechanism of insulin resistance in puberty, and the consequence of insulin resistance on muscle protein metabolism in liver disease. The ultimate goal of these studies is to develop effective intervention strategies for optimal clinical and nutritional management of these physiological and pathophysiological states.

The mechanism of reduced environmental oxygen and hypoxemia on intrauterine growth restriction is being examined in the rat model of pregnancy. The alterations in transport of nutrients, e.g. glucose and amino acids, from the mother to the fetus are quantified using in vivo and in vitro methods.

Selected Publications
Kalhan SC, Parimi P, Van Beek R, Gilfillan C, Saker F, Gruca L, Sauer PJJ: Estimation of gluconeogenesis in newborn infants. Am J Physiol 281:E991-E997, 2001.

Kalhan SC, Mahajan S, Burkett E, Reshef L, Hanson RW: Glyceroneogenesis and the source of glycerol for hepatic triacylglycerol synthesis in humans. J Biol Chem 276: 12928-12931, 2001.

Kalhan S, Rossi K, Gruca L: Decompensation of leucine nitrogen turnover in gestational diabetes. Diabetes Care 23:1033-4, 2000.

Kalhan S, Peter-Wohl S: Hypoglycemia: What is it for the neonate? Am J Perinatol 17:11-18, 2000.

Kalhan S: Protein metabolism in human pregnancy. Am J Clin Nutr 71:1249S-1255S, 2000.

Perry Kannan, Ph.D.
Staff Scientist (Associate Professor)
TEL: (216) 778-1156
FAX: (216) 778-7554


Research Interest(s)
My laboratory is focused on delineating the molecular events of oncogenesis, especially the pivotal roles played by transcription factors. We have taken transcription factor AP-2 as a model system. Deregulation of AP-2 has been implicated in many carcinogenic events including Ras-oncogenic signal transduction pathway, breast cancer, adenocarcinoa and melanoma. We are particularly interested in two of these carcinogenic events. One is the oncogenicity induced by the HER-2 proto-oncogene which is overexpressed in about one fourth of human breast cancers. AP-2 transcription factors bind to the HER-2 gene promoter and activate its expression. In a striking concurrence, anomalous abundance of AP-2alpha protein or its homolog AP-2gamma is also detected with HER-2 in mammary tumor-derived cell lines. This indicates that deregulation of AP-2 is the preceding pathogenic event and probably the pivotal one in this type of mammary carcinogenesis. My laboratory examined the process of AP-2 gene expression in mammary carcinoma cell lines to pinpoint where the aberration had occurred. We excluded a number of possibilities such as increased gene copy number, gene transcription, and mRNA stability. We find that AP-2 proteins have extended stability in breast cancer cell lines. Further investigation reveals that the breast cancer cells are defective in the ubiquitin-dependent proteasomal-degradation pathway which results in the accumulation of AP-2 proteins. Our studies confirm that this defect is the prime reason that eventually causes overexpression of HER-2 gene and culminates in breast cancer. In this ongoing research, we are tracking the disease further backwards to identify the nature of the aberration in the proteasomal-degradation pathway, studying the prevalence in breast cancer patients and developing prognostic markers and strategies for pharmacological intervention. The second one is the ras-oncogene signal transduction pathway in teratocarcinoma. Intriguingly, AP-2 causes sequestration of coactivators when it is aberrantly overexpressed in ras-transformed cells. Our investigation reveals that many accessory proteins are necessary for the normal functioning of transcription factor AP-2 which it shares with other activators. The balance of cellular transcriptional activity is affected when the levels of AP-2 proteins are anomalously high. We identified two coactivators: positive coactivator-4 and poly(ADP-ribose) polymerase-1. Our studies show that both have tumor suppressor property.

Selected Publications
Li, M., Naidu, P., Yu, Y., Berger, N. A., and Kannan, P. 2004. Dual regulation of AP-2a transcriptional activation by poly(ADP-Ribose) polymerase-1. Biochem. J. 382:323-329 Go to Publication

Li, M., Wang, Y., Yu, Y., Li, M., Nishizawa, M., Nakajima, T., Ito, S., and Kannan, P. 2002. The human transcription factor AP 2gamma: gene structure, promoter, and expression in mammary carcinoma cell lines. Gene 302:43-51 Go to Publication

Wankhade S, Yu Y, Weinberg J, Tainsky MA, Kannan P. 2000. Characterization of the activation domains of AP-2 family transcription factors. J Biol Chem. 275:29701-29708. Go to Publication

Kannan P, Yu Y, Wankhade S, Tainsky MA. 1999. PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation. Nucleic Acids Res. 27:866-874. Go to Publication

Kannan P, Tainsky MA. 1999. Coactivator PC4 mediates AP-2 transcriptional activity and suppresses ras-induced transformation dependent on AP-2 transcriptional interference. Mol Cell Biol. 19:899-908. Go to Publication

Irene L. Katzan, M.D., M.S.
Assistant Professor of Neurology
Senior Researcher
Center for Health Care Research and Policy
Director, Strokes Outcomes Research Program
TEL: (216) 778-7498
FAX: (216) 778-3945

Biosketch

Research Interest(s)
Outcomes of Stroke and other Neurologic Diseases. Special areas of interest include: effectiveness of stroke therapies in community setting, effect of medical complications on outcomes after stroke, healthcare utilization for stroke.

Selected Publications
Katzan IL, Cebul RD, Husak SH, Dawson NV, Baker DW. The Effect of Pneumonia on Mortality Among Patients Hospitalized for Acute Stroke. Neurology 2003;60:620-625.

Katzan IL, Graber TM, Furlan AJ, Sundararajan S, Sila CA, Houser G, Landis DM Cuyahoga County Operation Stroke: Speed of Emergency Department Evaluation and Compliance with NINDS Time Targets. Stroke 2003;34:994-998.

Katzan IL, Hammer MD, Furlan AJ, Hixson ED, Nadzam DM. Quality Improvement and Tissue-Type Plasminogen Activator for Acute Ischemic Stroke: A Cleveland Update. Stroke 2003;34:799-800.

Katzan IL, Hammer MD, Furlan AJ, Hixson ED, Abou-Chebl A, Nadzam DM. Utilization of Intravenous Tissue Plasminogen Activator for Acute Ischemic Stroke. Arch Neurol 2004;61:346-350.

Elizabeth Kaufman, M.D.
Assistant Professor of Medicine
Cardiac Electrophysiologist
TEL: (216) 778-2249
FAX: (216) 778-3927

Curriculum Vitae

Research Interest(s)
Long QT syndrome, T wave alternans, cardiac arrhythmias, autonomic control of the heart, prevention of sudden cardiac death.

Selected Publications
Kaufman ES, Priori SG, Napolitano C, Schwartz PJ, Iyengar S, Elston RC, Schnell AH, Gorodeski EZ, Rammohan G, Bahhur NO, Connuck D, Verrilli L, Rosenbaum DS, Brown AM. Electrocardiographic prediction of abnormal genotype in congenital long QT syndrome: experience in 101 related family members. J Cardiovasc Electrophysiol 2001;12:455-461

Kaufman ES, Mackall JA, Julka B, Drabek C, Rosenbaum DS. Influence of heart rate and sympathetic stimulation on arrhythmogenic T-wave alternans. Am J Physiol Heart Circ Physiol 2000;279(3):H1248-H1255.

Moss AJ, Zareba W, Kaufman ES, Gartman E, Peterson DR, Benhorin J, Towbin JA, Keating MT, Priori SG, Schwartz PJ, Vincent GM, Robinson JL, Andrews ML, Feng C, Hall WJ, Medina A, Zhang L, Wang Z. Increased risk of arrhythmic events in long QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel. Circulation 2002;105:794-799.

Michael W. Keith, M.D.
Director, Division of Hand Surgery
Department of Orthopaedics
MetroHealth Medical Center
Professor of Orthopaedics and BioMedical Engineering
Case Western Reserve University
TEL: (216) 778-4399
FAX: (216) 778-4690



Research Interest(s)
Spinal Cord Injury

Kevin Kilgore, Ph.D.
Staff Scientist, Dept. of Orthopaedics
MetroHealth Medical Center
Case Western Reserve University
TEL: (216) 778-3801


Web Page

Research Interest(s)
Functional Electrical Stimulation, with a focus on providing hand function for individuals with spinal cord injury.

Selected Publications
Kilgore KL, Peckham PH, Keith MW, Montague FW, Hart RL, Gazdik MM, Bryden AM, Snyder SA, Stage TG. The durability of implanted electrodes and leads in upper extremity neuroprostheses. J. Rehab Research and Development 40(6):457-468, 2003.

Peckham PH, Keith MW, Kilgore KL, Grill JH, Wuolle KS, Thrope GB, Gorman P, Hobby J, Mulcahey MJ, Carroll S, Hentz V, Wiegner A., Efficacy of an Implanted Neuroprosthesis for Restoring Hand Grasp in Tetraplegia: A Multicenter Study, Arch. Physical Medicine and Rehabilitation, 82:1380-8, 2001.

Kilgore KL, Scherer M, Bobblitt R, Dettloff J, Dombrowski DM, Godbold N, Jatich JW, Morris R, Penko JS, Schremp ES, Cash LA, Neuroprosthesis consumers` forum: consumer priorities for research directions, J Rehabilitation Research and Development, 38:655-660, 2001

John P. Kirwan, Ph.D., FACSM
Associate Professor of Reproductive Biology, Nutrition, Physiology & Biophysics
Department of Nutrition
Case Western Reserve University at
MetroHealth Medical Center
TEL: (216) 778-8848
FAX: (216) 778-7101


Web Page for Profile

Research Interest(s)
Dr. Kirwan’s research expertise is in bench and human clinical investigation regarding nutrient metabolism, insulin action, body composition, and physical activity. He is currently performing research on the effects of age, exercise, and diet on insulin resistance and obesity in the elderly. Additional areas of focus are: to evaluate maternal metabolic, hormonal, genetic, and environmental determinants of fetal growth and body composition and to examine the mechanism(s) underlying improved insulin sensitivity in human skeletal muscle after exercise-training.

Selected Publications
KIRWAN, J.P., M. Jing, A. Varashtapoor, J. Shao, J.E. Friedman, and P.M. Catalano. Reversal of insulin resistance postpartum is linked to enhanced skeletal muscle insulin signaling. J. Clin. Endocrinol. Metab. (In Press), 2004.

KIRWAN, J.P. and L.F. del Aguila. Insulin signaling, exercise and cellular integrity. Biochem. Soc. Trans. 31: 1281-1285, 2003.

Krishnan RK, Evans WJ, KIRWAN JP. Glucose clearance is delayed after hyperglycemia in healthy elderly men. J Nut. 133: 2363-2366, 2003.

Krishnan, R.K., W.J. Evans, and J.P. KIRWAN. Impaired substrate oxidation in healthy elderly men after eccentric exercise. J. Appl. Physiol. 94: 716-723, 2003.

Catalano, P.M., J.P. KIRWAN, S. Hauguel-de Mouzon, and J. King. Gestational diabetes and insulin resistance: Role in short and long term implications for mother and fetus. J. Nutr. 133: 1674S-1683S, 2003.

Diana Kunze, Ph.D.
Professor of Neurosciences
Senior Staff Scientist Rammelkamp
TEL: (216) 778-8967
FAX: (216) 778-2090

Curriculum Vitae
Web Page

Research Interest(s)
Mechanisms of cardio-respiratory control. Areas of interest include (a) contributions of ion channels to the plasticity of blood pressure and heart rate control (b) role of ion channels in adaptions to intermittent hypoxia as a model for sleep apnea. Techniques include patch clamp electrophysiological analysis of cultured neurons and brain slice preparations, immunohistochemistry, calcium imaging, neuronal modeling, molecular biology including single cell RT-PCR and analysis of knockout mice with ion channel defects.

Selected Publications
Doan T.N.; Kunze, D.L. Contribution of the hyperpolarization-activated current (IH) to the resting membrane potential of neonatal rat nodose sensory neurons, J. Physiol. 514:125-138 1999

Balkowiec, A,. Kunze, D.L.; Katz, D Brain-derived neurotrophic factor acutely inhibits AMPA-mediated currents in developing sensory relay neurons. J Neurosci. 20:1904-11. 2000

Andrews, E. M., Kunze,D.L. Voltage-gated potassium channels in chemoreceptor sensory neurons of rat petrosal ganglion Br Research, 897:199-203 2001

Yuri Kuryshev, Ph.D.
Staff Scientist
TEL: (216) 778-8976
FAX: (216) 778-8282



Research Interest(s)
Iron-overloading and cardiac current abnormalities. Iron-induced myocardial disease is the most frequent cause of death in talassemia major and is a major life-limiting complication of transfusion-dependent refractory anemias hereditary hemochromatosis and other forms of iron overload. Our studies performed on isolated cardiomyocytes have identified iron-induced abnormalities both in overall cardiac action potential (CAP) and in specific membrane currents. In particular, we showed that iron-loaded cardiomyocytes had decreased overshoot and duration of the CAP, the Na+ current was deacreased, but K+ transient outward current was increased. The goals of our current research are to: 1) characterize the molecular basis of iron-induced abnormalities of ion currents in cardiac myocytes in culture and in a new animal model of the cardiomyopathy of iron overload, Mongolian gerbils, and 2) to determine the potential role of this abnormalities in pathophysiology of iron-overloaded heart.

Selected Publications
Kuryshev Ya, Wible BA, Gudz TI, Ramirez AN, Brown AM. KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression. Am J Physiol Cell Physiol. 2001 Jul;281(1):C290-9.

Mattera R, Stone GP, Bahhur N, Kuryshev YA. Increased release of arachidonic acid and eicosanoids in iron-overloaded cardiomyocytes. Circulation. 2001 May 15;103(19):2395-401.

Kuryshev YA, Brown AM, Wang L, Benedict CR, Rampe D. Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels. J Pharmacol Exp Ther. 2000 Nov;295(2):614-20.

Irving Kushner, M.D.
Professor of Medicine
Case Western Reserve University at
MetroHealth Medical Center
TEL: (216) 778-5988, (216) 778-4765
FAX: (216) 778-2770

Curriculum Vitae

Research Interest(s)
Dr. Kushner is studying the molecular mechanisms by which inflammation causes the liver to increase production of an important plasma protein, C-reactive protein (CRP). Two messenger molecules, produced at the site of inflammation, bind to receptors on the surface of liver cells, with consequent activation of several families of proteins (called transcription factors). They move to the nucleus and cause increased CRP transaction. The lab is defining the interactions between the transcription factors and the CRP gene.

Selected Publications
Agrawal A, Samols D, Kushner I. Transcription factor c-Rel enhances C-reactive protein expression by facilitating the binding of C/EBPbeta to the promoter. Mol Immunol. 2003 Oct;40(6):373-80

Agrawal A, Cha-Molstad H, Samols D, Kushner I. Overexpressed nuclear factor-kappaB can participate in endogenous C-reactive protein induction, and enhances the effects of C/EBPbeta and signal transducer and activator of transcription-3. Immunology. 2003 Apr;108(4):539-47

Agrawal A, Cha-Molstad H, Samols D, Kushner I. Transactivation of C-reactive protein by IL-6 requires synergistic interaction of CCAAT/enhancer binding protein beta (C/EBP beta) and Rel p50. J Immunol. 2001 Feb 15;166(4):2378-84. PMID: 11160296 [PubMed - indexed for MEDLINE]

Pincus T, Ferraccioli G, Sokka T, Larsen A, Rau R, Kushner I, Wolfe F. Evidence from clinical trials and long-term observational studies that disease-modifying anti-rheumatic drugs slow radiographic progression in rheumatoid arthritis: updating a 1983 review. Rheumatology (Oxford). 2002 Dec;41(12):1346-56

Kushner I, Sehgal AR. Is high-sensitivity C-reactive protein an effective screening test for cardiovascular risk? Arch Intern Med. 2002 Apr 22;162(8):867-9

Karen Kutoloski, D.O.
Director, Cardiac Rehabilitation
Assistant Professor
Case Western Reserve University
TEL: (216) 778-2431


Research Interest(s)
Preventative Cardiology, Cardiac imaging, Outcomes research, Clinical Trials

Kenneth Laurita, Ph.D.
Assistant Professor of Medicine and Biomedical Engineering
Senior Scientist
TEL: (216) 778-7340
FAX: (216) 778-1261

Curriculum Vitae

Research Interest(s)
Cellular mechanisms of cardiac arrhythmias using fluorescent imaging of transmembrane potential and intracellular calcium in the intact heart. Cardiac repolarization and its influence on arrhythmia vulnerability. Intracellular calcium homeostasis and its role in arrhythmogenesis. Mechanisms of cardiac impulse propagation and block. Instrumentation and software design for imaging the electrical activity of the heart.

Selected Publications
Laurita KR, Singal A. Mapping action potentials and calcium transients simultaneously from the intact heart. American Journal of Physiology. 2001;280:H2053-H2060.

Laurita KR, Rosenbaum DS. The interdependence of modulated dispersion and tissue structure in the mechanism of unidirectional block. Circulation Research. 2000;87:922-928.

Laurita KR, Girouard SD, Akar FG, Rosenbaum, DS. Modulated dispersion explains changes in arrhythmia vulnerability during premature stimulation of the heart. Circulation. 1998;98:2774-2780.

Michael M. Lederman, M.D.
Scott R. Inkley Professor of Medicine
Professor of Biomedical Ethics, Pathology, Microbiology and Molecular Biology
Director, Center for AIDS Research
Case Western Reserve University
TEL: (216) 844-8786
FAX: (216) 844-5523


Research Interest(s)
Identifying mechanisms of immune deficiency and host defenses in HIV disease, and in exploring methods to enhance them.

Selected Publications
Sieg, S.F., Bazdar, D.A., Lederman, M.D. Impaired T cell receptor-mediated induction of Ki67 by naïve CD4+ T cells is only occasionally corrected by exogenous interleukin-2 in HIV-1 infection. J. Immunology 171:5208-14, 2003.

Salkowitz, J.R., Sieg, S.F., Harding, C.V., Lederman, M.M. In vitro human memory CD8 T cell expansion in response to cytomegalovirus requires CD4+ T cell help. J. Inf. Dis. 204:971-83, 2004.

Martin, M.P., Lederman, M.M., Hutcheson, H., Nelson, G.W., Goedert, J.J., Detels, R., Buchbinder, S., Hoots, K., Vlahov, D., Obrien, D.J., Carrington, M., Association of DC-SIGN promoter polymorphisms with increased risk for parenteral but not mucosal acquisition of HIV-1 infection. J. Virol. 78:14053-56, 2004.

Lederman, M.M., Veazey, R., Hartley, O., Mosier, D., Dufour, J., Mefford, M., Piatak, M., Jr., Salkowitz, J.R., Rodriguez, B., Blauvelt, A., Offord, R. Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5. Science 306:485-7, 2004.

William Lewis, M.D.
Assistant Professor of Medicine
Director, Clinical Electrophysiology Section
TEL: (216) 778-2249
FAX: (216) 778-3927


Research Interest(s)
Cardiac Repolarization, Cardiac Arrhythmias, Cardiac Autonomic Control.

Selected Publications
Lewis, W., Carlson, M. Systolic Blood Pressure at Rest, Not the Degree of Beta Blockade, Predicts the Result of Follow-Up Tilt Table Testing for Vasovagal Syncope. Am J Cardiol 80:351-353, 1997.

Harrington MD, Luebke DL, Lewis WR, Auliso MP, Johnson NJ. Fast Facts and Concepts #112. IMPLANTABLE CARDIOVERTER DEFIBRILLATOR (ICD) AT END OF LIFE. April 2004. End-of-Life Physician Education Resource Center www.eperc.mcw.edu Go to Publication

Harrington MD, Luebke DL, Lewis WR, Auliso MP, Johnson NJ. Fast Facts and Concepts #111. Cardiac Pacemakers at End-of-life. April 2004. End-of-Life Physician Education Resource Center www.eperc.mcw.edu Go to Publication

Lewis W and Kaufman E. ECG monitoring. In Webb A, Shapiro M, Singer M and Suter P (Eds) Oxford Textbook of Critical Care, Oxford University Press, Oxford, New York, Tokyo, 1999, pp1083-1085

Lewis W. Protrusion of an Active Fixation Pacing Lead into the Abdominal Cavity. J Cardiovas Electrophysiology 11:944, 2000.

Thomas E. Love, Ph.D.
Assistant Professor of Medicine, CWRU School of Medicine
Assistant Professor of Operations, Weatherhead School of Management
Director, Biostatistics and Evaluation Unit,
Center for Health Care Research and Policy
TEL: (216) 778-1265
FAX: (216) 778-3945

Biosketch
Curriculum Vitae
Web Site for Dr. Love

Research Interest(s)
Statistics, Observational Studies, Quality Improvement, Psychometrics, Statistics Education

Selected Publications
Ahmed A Rich MW Love TE Lloyd Jones DM Aban IB Colucci WS Adams KF Gheorghiade M (2006) Digoxin and reduction in mortality and hospitalization in heart failure: A comprehensive post hoc analysis of the DIG trial. European Heart Journal 27: 178-186. With accompanying Editorial by Brophy JM Rehabilitating digoxin.

Bailit JL Love TE Dawson NV (2006) Quality of obstetric care and risk-adjusted primary cesarean rates The American Journal of Obstetrics & Gynecology 194 (2): 402-407.

Litaker D Love TE (2005) Health care resource allocation and individuals` health care needs: Examining the degree of fit. Health Policy 73: 183-193.

Murray PK Love TE Dawson NV Thomas CL Cebul RD (2005) Rehabilitation services following the implementation of the nursing home prospective payment system: Differences related to patient and nursing home characteristics. Medical Care 43: 1109-15.

Love TE Hildebrand DK (2002) Statistics education and the Making Statistics More Effective in Schools and Business (MSMESB) conferences. The American Statistician 56: 107-112.

Rhoderick Machekano, Ph.D., M.P.H.
Assistant Professor of Medicine
Center for Health Care Research and Policy
Center for AIDS Research
Case Western Reserve University
TEL: (216) 778-1952
FAX: (216) 778-3945

Biosketch
Curriculum Vitae

Selected Publications
Machekano R, McFarland W, Hudes E, Bassett M, Mbizvo M, Katzenstein D. Correlates of HIV Test Results Seeking and Utilization of Partner Counseling Services in a Cohort of Male Factory Workers in Zimbabwe. AIDS and Behavior, Vol 4, No. 1, 200